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Long Term Survival Analysis in a Cohort of 125 Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using Small Drug Eluting Beads

  • Clinical Investigation
  • INTERVENTIONAL ONCOLOGY
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

Different types of drug-eluting beads have been proposed for hepatocellular carcinoma (HCC) treatment, but long-term results are not well known. We report safety, efficacy and long-term overall survival of HCC patients not amenable of curative therapies treated with transcatheter arterial chemoembolization (TACE) using drug-eluting beads sized 70–150 micron.

Materials and Methods

This single-center retrospective study included 125 patients with Barcelona Clinic Liver Cancer stage A (80), B (45) and compensated cirrhosis. TACE was executed injecting drug-elutings microparticles loaded with 75 mg of Doxorubicine and was repeated in patients with partial response or stable disease after one month. Adverse events, response according to modified Response Evaluation Criteria in Solid Tumors and overall survival were assessed.

Results

Chemoembolization with 70–150 micron beads revealed an objective response rate of 88% according to mRECIST criteria and complete response was 60%. After a median follow-up of 53.3 months, overall survival was 36.6 months. Data were censored at the date of liver transplantation in 35 patients. 33 on 125 patients (26,4%) experienced at least one adverse event. We recorded a total of 102 adverse events and 18 were of a high grade (G3–G4). 30 day mortality was 0%.

Conclusion

Chemoembolization with very small particles (70–150 µm) is an effective and safe treatment in unresectable HCC both as a primary therapy or as bridge to transplantation.

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Funding

This study was not supported by any funding.

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Authors and Affiliations

  1. Interventional Vascular and Hepatobiliary Unit, Department of Radiodiagnostics and Radiotherapy, IRCCS Fondazione Istituto Nazionale Tumori di Milano, Milan, Italy

    Tommaso Cascella, Enrico Matteo Garanzini, Rodolfo Lanocita, Carlo Morosi, Giorgio Greco, Alfonso Marchianò & Carlo Spreafico

  2. General Surgery and Liver Transplantation Unit, IRCCS Fondazione Istituto Nazionale Tumori di Milano, Milan, Italy

    Carlo Sposito & Vincenzo Mazzaferro

  3. Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

    Carlo Sposito & Vincenzo Mazzaferro

  4. Postgraduation School of Radiology, University of Milan, Milan, Italy

    Federica Riva

Authors
  1. Tommaso Cascella
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  2. Enrico Matteo Garanzini
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  3. Rodolfo Lanocita
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  4. Carlo Morosi
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  5. Federica Riva
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  6. Giorgio Greco
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  8. Vincenzo Mazzaferro
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  9. Alfonso Marchianò
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  10. Carlo Spreafico
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Corresponding author

Correspondence to Enrico Matteo Garanzini.

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Cascella, T., Garanzini, E.M., Lanocita, R. et al. Long Term Survival Analysis in a Cohort of 125 Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using Small Drug Eluting Beads. Cardiovasc Intervent Radiol 45, 54–61 (2022). https://doi.org/10.1007/s00270-021-02991-2

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  • DOI: https://doi.org/10.1007/s00270-021-02991-2

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