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Combination of Percutaneous Screw Fixation and Cementoplasty for Lytic Bone Metastases: Feasibility, Safety and Clinical Outcomes

  • Clinical Investigation
  • Musculoskeletal Interventions
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Objective

To evaluate feasibility, safety and efficacy of a combination of screw fixation and cementoplasty for pathologic bone fracture.

Methods

In this single-center prospective study, all consecutive percutaneous screw fixations under assisted CT guidance for palliation and fracture treatment of pathologic bone fracture were reviewed from July 2019 to February 2021. The primary outcome measure was the procedures’ technical success, defined as the correct placement of the screw(s), without any complications. Secondary outcome measures were the safety, the procedures’ early analgesic effects and impacts on quality of life at 4 weeks.

Results

Technical success was achieved in 11/11 procedures (100%) among 11 patients. No major complications attributable to the procedure were noted. The mean pain scored significantly decreased at the initial follow-up: 8.0 ± 2.7 versus 1.6 ± 2.5 (p < 0.05). Opioid doses were statistically lower after procedure: 70.9 ± 37 versus 48.2 ± 46 mg/day (p < 0.05). The mean EQ5D score had significantly increased by the early post-procedure consultation: 42.5 ± 13.6 vs 63.6 ± 10.3 (p < 0.05).

Conclusion

Combination of percutaneous screw fixation and cementoplasty for pathologic bone fracture is feasible and safe. It is efficient to reduce pain, decrease the consumption of opioids and improve the quality of life at 4 weeks after the procedure.

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Abbreviations

CT:

Computed tomography

CBCT:

Cone beam CT

NPRS:

Numerical pain rate Score

PS:

Performance status

EQ5D:

EuroQol 5 dimensions

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Acknowledgements

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Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Radiology, Hôpital Nord, University Hospital of Saint Etienne, Avenue Albert Raymond, 42055, Saint-Etienne cedex 2, France

    Sylvain Bertholon, Rémi Grange, Fabrice-Guy Barral & Sylvain Grange

  2. Department of Rhumatology, University Hospital of Saint Etienne, Avenue Albert Raymond, 42055, Saint-Etienne cedex 2, France

    Thierry Thomas

  3. Department of Neurosurgery, University Hospital of Saint Etienne, Avenue Albert Raymond, 42055, Saint-Etienne cedex 2, France

    Marie-Charlotte Tetard

  4. Department of Supportive Care in Oncology, Lucien Neuwirth Cancer Institute, 5 Rue Charles de Gaulle, 42055, Saint-Etienne cedex 2, France

    Aurelie Beneton & Stéphanie Morisson

Authors
  1. Sylvain Bertholon
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  2. Rémi Grange
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  3. Thierry Thomas
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  4. Marie-Charlotte Tetard
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  8. Sylvain Grange
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Contributions

SG, SB, SM and RG elaborated the project. SG, SB and SM collected the data. SB, SG and RG performed the procedure and wrote the manuscript. All authors managed the patients, corrected and validated the manuscript.

Corresponding author

Correspondence to Sylvain Grange.

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Conflict of interest

No potential conflict of interest was reported by the authors.

Ethical approval

This study has obtained approval from local research committee (“terre d’éthique” CHU Saint-Etienne IRBN942019/CHUSTE). The "clinical trial" document has been completed (NCT05191264).

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Informed consent was obtained from all individual participants included.

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Bertholon, S., Grange, R., Thomas, T. et al. Combination of Percutaneous Screw Fixation and Cementoplasty for Lytic Bone Metastases: Feasibility, Safety and Clinical Outcomes. Cardiovasc Intervent Radiol 45, 1129–1133 (2022). https://doi.org/10.1007/s00270-022-03186-z

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  • DOI: https://doi.org/10.1007/s00270-022-03186-z

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