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Postinterventional Patient Comfort After Uterine Artery Embolization and Superior Hypogastric Nerve Block

  • Technical Note
  • Embolisation (arterial)
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Abstract

Purpose

To evaluate the duration and effect of superior hypogastric nerve block (SHNB) with ropivacaine and clonidine on postinterventional pain levels and opioid requirements in patients undergoing uterine artery embolization.

Materials and Methods

Postinterventional pain levels (numeric rating scale, NRS 0–10) and opioid doses were retrospectively analyzed in 53 patients undergoing transfemoral uterine artery embolization and intraprocedural superior hypogastric nerve block during 24 h. A mixture of 150 mg of ropivacaine and 150 µg of clonidine was used for the block.

Results

Postinterventional pain averaged between 1.4 and 2.0 during the first 9 h, after which a small but significant increase was observed (NRS 1.7 ± 1.6 vs. NRS 2.6 ± 2.2, p < 0.001). 70% of patients did not exceed a tolerable pain threshold of NRS 4 during the first 9 h after the intervention. Thirty-three patients (62%) did not require any opioid medication. Mean iv morphine dose was 3.1 ± 4.7 mg, whereas 71% of opioid doses were administered after 9 h.

Conclusion

Superior hypogastric nerve block using a mixture of ropivacaine and clonidine provides good pain relief for 9 h after uterine artery embolization requiring only very low amounts of additional opioids.

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Fig. 1
Fig. 2

Abbreviations

EDA:

Epidural anesthesia

LAST:

Local anesthetic systemic toxicity

NRS:

Numeric rating scale

PCA:

Patient-controlled anesthesia

RPC:

Retained products of conception

SHNB:

Superior hypogastric nerve block

UAE:

Uterine artery embolization

VAS:

Visual analog scale

References

  1. American College of Obstetricians and Gynecologists (2021) Management of symptomatic uterine leiomyomas: ACOG practice bulletin, number 228. Obstet Gynecol 137:100–115. https://doi.org/10.1097/AOG.0000000000004401

  2. Gupta JK, Sinha A, Lumsden MA et al. (2014) Uterine artery embolization for symptomatic uterine fibroids. Cochrane Database Syst Rev 2014:CD005073. https://doi.org/10.1002/14651858.CD005073.pub4

  3. Han K, Kim SY, Kim HJ, et al. Nonspherical polyvinyl alcohol particles versus tris-acryl microspheres: randomized controlled trial comparing pain after uterine artery embolization for symptomatic fibroids. Radiology. 2021;298:458–65. https://doi.org/10.1148/radiol.2020201895.

    Article  Google Scholar 

  4. Kim SY, Chang CH, Lee JS, et al. Comparison of the efficacy of dexmedetomidine plus fentanyl patient-controlled analgesia with fentanyl patient-controlled analgesia for pain control in uterine artery embolization for symptomatic fibroid tumors or adenomyosis: a prospective, randomized study. J Vasc Interv Radiol. 2013;24:779–86. https://doi.org/10.1016/j.jvir.2013.02.034.

    Article  Google Scholar 

  5. Kim SY, Koo B-N, Shin CS, et al. The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: a randomised controlled study. BJOG Int J Obstet Gynaecol. 2016;123:580–7. https://doi.org/10.1111/1471-0528.13785.

    Article  CAS  Google Scholar 

  6. Ruuskanen A, Sipola P, Hippeläinen M, et al. Pain after uterine fibroid embolisation is associated with the severity of myometrial ischaemia on magnetic resonance imaging. Eur Radiol. 2009;19:2977–85. https://doi.org/10.1007/s00330-009-1481-8.

    Article  Google Scholar 

  7. Kim HS, Czuczman GJ, Nicholson WK, et al. Pain levels within 24 hours after UFE: a comparison of morphine and fentanyl patient-controlled analgesia. Cardiovasc Interv Radiol. 2008;31:1100–7. https://doi.org/10.1007/s00270-008-9430-5.

    Article  Google Scholar 

  8. Spencer EB, Stratil P, Mizones H. Clinical and periprocedural pain management for uterine artery embolization. Semin Interv Radiol. 2013;30:354–63. https://doi.org/10.1055/s-0033-1359729.

    Article  Google Scholar 

  9. Saibudeen A, Makris GC, Elzein A, et al. Pain management protocols during uterine fibroid embolisation: a systematic review of the evidence. Cardiovasc Interv Radiol. 2019;42:1663–77. https://doi.org/10.1007/s00270-019-02327-1.

    Article  Google Scholar 

  10. Chan P, Garcia-Reyes K, Cronan J, et al. Managing postembolization syndrome-related pain after uterine fibroid embolization. Semin Interv Radiol. 2021;38:382–7. https://doi.org/10.1055/s-0041-1731406.

    Article  Google Scholar 

  11. Binkert CA, Hirzel FC, Gutzeit A, et al. Superior hypogastric nerve block to reduce pain after uterine artery embolization: advanced technique and comparison to epidural anesthesia. Cardiovasc Interv Radiol. 2015;38:1157–61. https://doi.org/10.1007/s00270-015-1118-z.

    Article  Google Scholar 

  12. Malouhi A, Aschenbach R, Erbe A, et al. Effektivität und Sicherheit der Blockade des Plexus hypogastricus superior zur Schmerzkontrolle im Vergleich zur Epiduralanästhesie bei arterieller Embolisation in der Myombehandlung—eine restrospektive Evaluation. Rofo. 2021;193:289–97. https://doi.org/10.1055/a-1231-5649.

    Article  Google Scholar 

  13. Duvnjak S, Andersen PE. Intra-arterial lidocaine administration during uterine fibroid embolization to reduce the immediate postoperative pain: a prospective randomized study. CVIR Endovasc. 2020;3:10. https://doi.org/10.1186/s42155-020-0099-4.

    Article  Google Scholar 

  14. Noel-Lamy M, Tan KT, Simons ME, et al. Intraarterial lidocaine for pain control in uterine artery embolization: a prospective, randomized study. J Vasc Interv Radiol. 2017;28:16–22. https://doi.org/10.1016/j.jvir.2016.10.001.

    Article  Google Scholar 

  15. Keyoung JA, Levy EB, Roth AR, et al. Intraarterial lidocaine for pain control after uterine artery embolization for leiomyomata. J Vasc Interv Radiol. 2001;12:1065–9. https://doi.org/10.1016/S1051-0443(07)61592-9.

    Article  CAS  Google Scholar 

  16. Katsumori T, Miura H, Yoshikawa T, et al. Intra-arterial lidocaine administration for anesthesia after uterine artery embolization with trisacryl gelatin microspheres for leiomyoma. J Vasc Interv Radiol. 2020;31:114–20. https://doi.org/10.1016/j.jvir.2019.09.007.

    Article  Google Scholar 

  17. Liu S, Li W. Intra-arterial lidocaine for pain control after uterine artery embolization: a meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2020;2020:1–6. https://doi.org/10.1080/14767058.2020.1847079.

    Article  CAS  Google Scholar 

  18. Shiwani TH. Shiwani H Intra-arterial anaesthetics for pain control in arterial embolisation procedures: a systematic review and meta-analysis. CVIR Endovasc. 2021;4:6. https://doi.org/10.1186/s42155-020-00198-z.

    Article  Google Scholar 

  19. Pereira K, Morel-Ovalle LM, Wiemken TL, et al. Intraprocedural superior hypogastric nerve block allows same-day discharge following uterine artery embolization. J Vasc Interv Radiol. 2020;31:388–92. https://doi.org/10.1016/j.jvir.2019.08.017.

    Article  Google Scholar 

  20. Stewart JK, Patetta MA, Burke CT. Superior hypogastric nerve block for pain control after uterine artery embolization: effect of addition of steroids on analgesia. J Vasc Interv Radiol. 2020;31:1005-1009.e1. https://doi.org/10.1016/j.jvir.2020.02.026.

    Article  Google Scholar 

  21. Park PJ, Kokabi N, Nadendla P, et al. Efficacy of intraprocedural superior hypogastric nerve block in reduction of postuterine artery embolization narcotic analgesia use. Can Assoc Radiol J. 2020;71:75–80. https://doi.org/10.1177/0846537119888391.

    Article  Google Scholar 

  22. Yoon J, Valenti D, Muchantef K, et al. Superior hypogastric nerve block as post-uterine artery embolization analgesia: a randomized and double-blind clinical trial. Radiology. 2018;289:248–54. https://doi.org/10.1148/radiol.2018172714.

    Article  Google Scholar 

  23. Zambito Marsala S, Pistacchi M, Tocco P, et al. Pain perception in major depressive disorder: a neurophysiological case-control study. J Neurol Sci. 2015;357:19–21. https://doi.org/10.1016/j.jns.2015.06.051.

    Article  Google Scholar 

  24. Hermesdorf M, Berger K, Baune BT, et al. Pain sensitivity in patients with major depression: differential effect of pain sensitivity measures, somatic cofactors, and disease characteristics. J Pain. 2016;17:606–16. https://doi.org/10.1016/j.jpain.2016.01.474.

    Article  Google Scholar 

  25. Michaelides A, Zis P. Depression, anxiety and acute pain: links and management challenges. Postgrad Med. 2019;131:438–44. https://doi.org/10.1080/00325481.2019.1663705.

    Article  Google Scholar 

  26. Rasuli P, Jolly EE, Hammond I, et al. Superior hypogastric nerve block for pain control in outpatient uterine artery embolization. J Vasc Interv Radiol. 2004;15:1423–9. https://doi.org/10.1097/01.RVI.0000137406.09852.A4.

    Article  Google Scholar 

  27. Sheikh GT, Najafi A, Cunier M, et al. Angiographic detection of utero-ovarian anastomosis and influence on ovarian function after uterine artery embolization. Cardiovasc Interv Radiol. 2020;43:231–7. https://doi.org/10.1007/s00270-019-02305-7.

    Article  Google Scholar 

  28. Razavi MK, Wolanske KA, Hwang GL, et al. Angiographic classification of ovarian artery-to-uterine artery anastomoses: initial observations in uterine fibroid embolization. Radiology. 2002;224:707–12. https://doi.org/10.1148/radiol.2243011513.

    Article  Google Scholar 

  29. Woo A, Lechner B, Fu T, et al. Cut points for mild, moderate, and severe pain among cancer and non-cancer patients: a literature review. Ann Palliat Med. 2015;4:176–83. https://doi.org/10.3978/j.issn.2224-5820.2015.09.04.

    Article  Google Scholar 

  30. Gerbershagen HJ, Rothaug J, Kalkman CJ, et al. Determination of moderate-to-severe postoperative pain on the numeric rating scale: a cut-off point analysis applying four different methods. Br J Anaesth. 2011;107:619–26. https://doi.org/10.1093/bja/aer195.

    Article  CAS  Google Scholar 

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Funding

This study was not supported by any funding.

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Correspondence to Christoph A. Binkert.

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Conflict of interest

DAS has received research support from Philips Healthcare.

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Consent for publication was obtained for every individual person’s data included in the study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. The study was approved by the local ethics committee (BASEC-ID 2021-02089).

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Informed consent was obtained from all individual participants included in the study.

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Steffen, D.A., Najafi, A. & Binkert, C.A. Postinterventional Patient Comfort After Uterine Artery Embolization and Superior Hypogastric Nerve Block. Cardiovasc Intervent Radiol 46, 152–157 (2023). https://doi.org/10.1007/s00270-022-03290-0

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  • DOI: https://doi.org/10.1007/s00270-022-03290-0

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