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PEGylated polypyrrole–gold nanocomplex as enhanced photothermal agents against tumor cells

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Abstract

The development of dual-component photothermal agents is of great importance for effective photothermal tumor treatment. As an attractive component, gold (Au) nanoparticles (NPs) were found in possession of the capacity to enhance the photothermal conversion capacity of metal-based components. However, their interaction with organic polymer-based photothermal agents is rarely explored. Herein, a novel PEGylated polypyrrole–gold nanocomplex was fabricated as the photothermal agent for enhanced photothermal treatment against tumor cells. Using poly(ethyleneimine) (PEI) as the stabilizer, polypyrrole (PPy) NPs were formed in the presence of ferrous ions. After polyethylene glycol (PEG) modification and Au NP loading, PPy–PEI–PEG/Au NPs were formed. They owned desirable colloid stability and excellent photothermal stability. The loaded Au NPs could improve the photothermal conversion efficiency of PPy NPs through the potential coupling between the localized surface plasma resonance of Au NPs and the conductivity of PPy NPs. They were highly cytocompatible and could be internalized into tumor cells effectively. Under near-infrared light irradiation, effective tumor cell death could be achieved by PPy–PEI–PEG/Au NPs. This developed dual-component photothermal agent is promising in tumor treatment with high efficacy.

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References

  1. 1

    Opoku-Damoah Y, Wang R, Zhou J, Ding Y (2016) Versatile nanosystem-based cancer theranostics: Design inspiration and predetermined routing. Theranostics 6:986–1003

  2. 2

    Gai S, Yang G, Yang P et al (2018) Recent advances in functional nanomaterials for light-triggered cancer therapy. Nano Today 19:146–187

  3. 3

    Tang Z, Liu Y, He M, Bu W (2019) Chemodynamic therapy: tumour microenvironment-mediated Fenton and Fenton-like reactions. Angew Chem Int Ed 58:946–956

  4. 4

    Hu R, Fang Y, Huo M et al (2019) Ultrasmall Cu2−xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow. Biomaterials 206:101–114

  5. 5

    Liu T, Zhang M, Liu W et al (2018) Metal ion/tannic acid assembly as a versatile photothermal platform in engineering multimodal nanotheranostics for advanced applications. ACS Nano 12:3917–3927

  6. 6

    Cheng L, Zhang F, Wang S et al (2019) Activation of prodrugs by NIR-triggered release of exogenous enzymes for locoregional chemo-photothermal therapy. Angew Chem Int Ed 58:7728–7732

  7. 7

    Xue X, Huang Y, Bo R et al (2018) Trojan horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment. Nat Commun 9:3653

  8. 8

    Zheng Y, Wang W, Zhao J et al (2019) Preparation of injectable temperature-sensitive chitosan-based hydrogel for combined hyperthermia and chemotherapy of colon cancer. Carbohyd Polym 222:115039

  9. 9

    Liu Y, Xi Y, Zhao J et al (2019) Preparation of therapeutic-laden konjac hydrogel for tumor combination therapy. Chem Eng J 375:122048

  10. 10

    Wu D, Duan X, Guan Q et al (2019) Mesoporous polydopamine carrying manganese carbonyl responds to tumor microenvironment for multimodal imaging-guided cancer therapy. Adv Funct Mater 29:1900095

  11. 11

    Wang J, Wang X, Lu S-Y et al (2019) Integration of cascade delivery and tumor hypoxia modulating capacities in core-releasable satellite nanovehicles to enhance tumor chemotherapy. Biomaterials 223:119465

  12. 12

    Liu Y, Bhattarai P, Dai Z, Chen X (2019) Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev 48:2053–2108

  13. 13

    Chen Q, Wen J, Li H, Xu Y, Liu F, Sun S (2016) Recent advances in different modal imaging-guided photothermal therapy. Biomaterials 106:144–166

  14. 14

    Li X, Wang X, Sha L et al (2018) Thermosensitive lipid bilayer-coated mesoporous carbon nanoparticles for synergistic thermochemotherapy of tumor. ACS Appl Mater Interfaces 10:19386–19397

  15. 15

    Zhou L, Jing Y, Liu Y et al (2018) Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics. Theranostics 8:663–675

  16. 16

    Hu Y, Wang R, Zhou Y et al (2018) Targeted dual-mode imaging and phototherapy of tumors using ICG-loaded multifunctional MWCNTs as a versatile platform. J Mater Chem B 6:6122–6132

  17. 17

    Zhou J, Jiang Y, Hou S et al (2018) Compact plasmonic blackbody for cancer theranosis in the near-infrared II window. ACS Nano 12:2643–2651

  18. 18

    Wang Q, Wang H, Yang Y et al (2019) Plasmonic Pt superstructures with boosted near-infrared absorption and photothermal conversion efficiency in the second biowindow for cancer therapy. Adv Mater 31(46):1904836

  19. 19

    Xu C, Teng Z, Zhang Y et al (2018) Flexible MoS2-embedded human serum albumin hollow nanocapsules with long circulation times and high targeting ability for efficient tumor ablation. Adv Funct Mater 28:1804081

  20. 20

    Wang Y, Huang Q, He X et al (2018) Multifunctional melanin-like nanoparticles for bone-targeted chemo-photothermal therapy of malignant bone tumors and osteolysis. Biomaterials 183:10–19

  21. 21

    Xu L, Wang J, Lu SY et al (2019) Construction of a polypyrrole-based multifunctional nanocomposite for dual-modal imaging and enhanced synergistic phototherapy against cancer cells. Langmuir ACS J Surf Colloids 35:9246–9254

  22. 22

    Wang D, Wu H, Zhou J et al (2018) In situ one-pot synthesis of MOF-polydopamine hybrid nanogels with enhanced photothermal effect for targeted cancer therapy. Adv Sci 5:1800287

  23. 23

    Zhou Y, Hu Y, Sun W et al (2017) Polyaniline-loaded gamma-polyglutamic acid nanogels as a platform for photoacoustic imaging-guided tumor photothermal therapy. Nanoscale 9:12746–12754

  24. 24

    Xiong Y, Sun F, Zhang Y et al (2019) Polydopamine-mediated bio-inspired synthesis of copper sulfide nanoparticles for T1-weighted magnetic resonance imaging guided photothermal cancer therapy. Colloids Surf B 173:607–615

  25. 25

    Wang J, Guo Y, Hu J et al (2018) Development of multifunctional polydopamine nanoparticles as a theranostic nanoplatform against cancer cells. Langmuir ACS J Surf Colloids 34:9516–9524

  26. 26

    Wang J, Tan X, Pang X, Liu L, Tan F, Li N (2016) MoS2 quantum dot@polyaniline inorganic-organic nanohybrids for in vivo dual-modal imaging guided synergistic photothermal/radiation therapy. ACS Appl Mater Interfaces 8:24331–24338

  27. 27

    Cao Y, Li S, Chen C et al (2018) Rattle-type Au@Cu2−xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy. Biomaterials 158:23–33

  28. 28

    Younis MR, Wang C, An R et al (2019) Low power single laser activated synergistic cancer phototherapy using photosensitizer functionalized dual plasmonic photothermal nanoagents. ACS Nano 13:2544–2557

  29. 29

    Feng W, Han X, Wang R et al (2019) Nanocatalysts-augmented and photothermal-enhanced tumor-specific sequential nanocatalytic therapy in both NIR-I and NIR-II biowindows. Adv Mater 31:1805919

  30. 30

    Guo B, Zhao J, Wu C et al (2019) One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity. Colloids Surf B 177:346–355

  31. 31

    Yang Z, He W, Zheng H et al (2018) One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy. Biomaterials 161:1–10

  32. 32

    Liu H, Li W, Cao Y, Guo Y, Kang Y (2018) Theranostic nanoplatform based on polypyrrole nanoparticles for photoacoustic imaging and photothermal therapy. J Nanopart Res 20:57

  33. 33

    Yang K, Xu H, Cheng L, Sun C, Wang J, Liu Z (2012) In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles. Adv Mater 24:5586–5592

  34. 34

    Guo B, Zhao J, Zhang Z, An X, Huang M, Wang SG (2019) Intelligent nanoenzyme for T1-weighted MRI guided theranostic applications. Chem Eng J. https://doi.org/10.1016/j.cej.2019.123609

  35. 35

    Lan S, Xie W, Wang J et al (2018) PEGylated polyethylenimine-stabilized polypyrrole nanoparticles loaded with DOX for chemo-photothermal therapy of cancer cells. J Nanopart Res 20:300

  36. 36

    Feng L, Gai S, Dai Y et al (2018) Controllable generation of free radicals from multifunctional heat-responsive nanoplatform for targeted cancer therapy. Chem Mater 30:526–539

  37. 37

    Tang Z, Zhang H, Liu Y et al (2017) Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy. Adv Mater 29:1701683

  38. 38

    Liu H, Wang H, Xu YH et al (2014) Synthesis of PEGylated low generation dendrimer-entrapped gold nanoparticles for CT imaging applications. Nanoscale 6:4521–4526

  39. 39

    Liu C, Liu F, Feng L, Li M, Zhang J, Zhang N (2013) The targeted co-delivery of DNA and doxorubicin to tumor cells via multifunctional PEI–PEG based nanoparticles. Biomaterials 34:2547–2564

  40. 40

    Zhou B, Zheng L, Peng C et al (2014) Synthesis and characterization of PEGylated polyethylenimine-entrapped gold nanoparticles for blood pool and tumor CT imaging. ACS Appl Mater Interfaces 6:17190–17199

  41. 41

    Liu H, Shen MW, Zhao JL et al (2012) Tunable synthesis and acetylation of dendrimer-entrapped or dendrimer-stabilized gold-silver alloy nanoparticles. Colloid Surf B 94:58–67

  42. 42

    Wang X, Cai X, Hu J et al (2013) Glutathione-triggered “off-on” release of anticancer drugs from dendrimer-encapsulated gold nanoparticles. J Am Chem Soc 135:9805–9810

  43. 43

    Shi X, Wang S, Meshinchi S et al (2007) Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging. Small 3:1245–1252

  44. 44

    Zhang L, Wan SS, Li CX, Xu L, Cheng H, Zhang XZ (2018) An adenosine triphosphate-responsive autocatalytic fenton nanoparticle for tumor ablation with self-supplied H2O2 and acceleration of Fe(III)/Fe(II) conversion. Nano Lett 18:7609–7618

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Acknowledgement

This research was funded by the National Natural Science Foundation of China (51703184), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2017jcyjAX0066), the Fundamental Research Funds for the Central Universities from Southwest University (XDJK2018B007), and the support from Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices.

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Correspondence to Hui Liu.

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Hu, J., Wang, J., Tang, W. et al. PEGylated polypyrrole–gold nanocomplex as enhanced photothermal agents against tumor cells. J Mater Sci 55, 5587–5599 (2020). https://doi.org/10.1007/s10853-020-04384-1

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