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Chronic Endometritis and Recurrent Pregnancy Loss

  • Reproductive Endocrinology and Infertility (REI) (R Anchan, Section Editor)
  • Published:
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Abstract

Purpose of Review

Chronic endometritis is generally an asymptomatic condition typically diagnosed by the histopathological presence of plasma cell infiltration in the endometrial stromal compartment. Emerging data suggests that chronic endometritis may be a cause of recurrent pregnancy loss (RPL).

Recent Findings

Chronic endometritis is prevalent in cases of otherwise unexplained recurrent pregnancy loss. Treatment appears to lead to improved pregnancy outcomes in subsequent pregnancies. The use of CD138 immunohistochemistry as a supplement to traditional hematoxylin and eosin staining of plasma cells increases the detection rate of chronic endometritis.

Summary

Chronic endometritis is emerging as a treatable cause of RPL.

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Authors and Affiliations

  1. Program for Early and Recurrent Pregnancy Loss (PEARL), Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Montefiore Medical Center, 1301 Morris Park, Bronx, NY, 10461, USA

    Nicole Sahasrabudhe, Marjon Mobasseri & Zev Williams

  2. Department of Obstetrics and Gynecology, Brooklyn Hospital Center, Brooklyn, NY, 11201, USA

    Marjon Mobasseri

  3. Department of Pathology, Department of Obstetrics & Gynecology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, 10461, USA

    Sandra E. Reznik

  4. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY, 11439, USA

    Sandra E. Reznik

Authors
  1. Nicole Sahasrabudhe
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  2. Marjon Mobasseri
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  3. Sandra E. Reznik
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  4. Zev Williams
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Corresponding author

Correspondence to Zev Williams.

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Conflict of Interest

Nicole Sahasrabudhe, Marjon Mobasseri, Sandra E. Reznik, and Zev Williams declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Reproductive Endocrinology and Infertility (REI)

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Sahasrabudhe, N., Mobasseri, M., Reznik, S.E. et al. Chronic Endometritis and Recurrent Pregnancy Loss. Curr Obstet Gynecol Rep 6, 55–61 (2017). https://doi.org/10.1007/s13669-017-0189-z

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  • DOI: https://doi.org/10.1007/s13669-017-0189-z

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