Skip to main content

Advertisement

Log in

Gynecologic Care for Transgender Adults

  • Care for the Transgender Patient (C Unger, Section Editor)
  • Published:
Current Obstetrics and Gynecology Reports Aims and scope Submit manuscript

Abstract

Purpose of the Review

Transgender people need both routine gynecological and reproductive health care and services specific to gender-affirming processes. However, there is little evidence to guide their routine gynecological and reproductive health care, and data suggests that 33% of transgender people avoid routine health care due to persistent discrimination and disrespect. Here we systematically approach the care of transmasculine and transfeminine people for practicing obstetrician-gynecologists (OBGYNs) with an eye towards enhancing knowledge and enhancing respectful care.

Recent Findings

Though hampered by a paucity of high-quality data specific to transgender people, topics covered in the review include routine health care maintenance; including cancer screening, assessment of sexually transmitted infections, and contraception; as well as issues specific to transgender individuals such as to use of gender-affirming hormones and care surrounding gender-affirming surgeries. Additionally, we incorporate perspectives to support cultural humility and provider preparedness towards promoting patient comfort in seeking and obtaining care.

Summary

We aim to demonstrate that though there are some clinical topics specific to transgender people and their health care that warrant enhanced training and resources, obstetrician-gynecologists (OBGYNs) are actually well-poised to support the care of this population. Bringing awareness of the needs of transgender people to OBGYNs will help decrease the well-documented care gap for this underserved population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Institute of Medicine (U.S.). Committee on Lesbian G, Bisexual, and Transgender Health Issues and Research Gaps and Opportunities. The health of lesbian, gay, bisexual, and transgender people: building a foundation for better understanding. Washington, DC: National Academies Press; 2011.

    Google Scholar 

  2. Makadon HJ, Mayer KH, Potter J, Goldhammer H. Fenway guide to lesbian, gay, bisexual, and transgender health. 2nd ed. Philadelphia: American College of Physicians; 2015.

    Google Scholar 

  3. • Grant J.M., Mottet L.A., Tanis J., Harrison J., Herman J.L., Keisling M. Injustice at every turn: a report of the national transgender discrimination survey. In: National Center for Transgender Equality and National Gay and Lesbian Task Force, ed. Washington; 2011. A sentinal cross-sectional study on the experience of transgender individuals in American society; it includes reports on health and health care as well as education, housing, civic engagement, among others.

  4. Erickson-Schroth L. Trans bodies, trans selves: a resource for the transgender community. 1st ed. New York: Oxford University Press; 2014.

    Google Scholar 

  5. American College of Obstetrics and Gynecology (ACOG). Committee opinion no. 512: health care for transgender individuals. Obstet Gynecol. 2011;118(6):1454–8.

    Article  Google Scholar 

  6. Obedin-Maliver J, Goldsmith ES, Stewart L, White W, Tran E, Brenman S, et al. Lesbian, gay, bisexual, and transgender-related content in undergraduate medical education. JAMA. 2011;306(9):971–7.

    Article  CAS  PubMed  Google Scholar 

  7. Educational Committee of the Council on Resident Education in Obstetrics and Gynecology. Educational objectives: core curriculum in obstetrics and gynecology. 10th ed. Washington, D.C.: American College of Obstetricians and Gynecologists; 2013.

    Google Scholar 

  8. Grimstad FW, Satterwhite CL, Wieneke CL. Assessing residency program approaches to the transgender health CREOG objective. Transgender Health. 2016;1(1):69–74.

    Article  Google Scholar 

  9. Unger CA. Care of the transgender patient: a survey of gynecologists’ current knowledge and practice. J Women’s Health (Larchmt). 2015;24(2):114–8.

    Article  Google Scholar 

  10. • Cahill S, Singal R, Grasso C, King D, Mayer K, Baker K, et al. Do ask, do tell: high levels of acceptability by patients of routine collection of sexual orientation and gender identity data in four diverse American community health centers. PLoS One. 2014;9(9):e107104. This study describes the response of patients to being asked diverse sexual orientation and gender identity questions at different clinical sites

    Article  PubMed  PubMed Central  Google Scholar 

  11. Sexual Minority Assessment Research Team (SMART). Best practices for asking questions about sexual orientation on surveys. In: Institute. TW, ed: The Williams Institute. 2009.

  12. The Gender Identity in U.S. Surveillance (GenIUSS) Group. Best practices for asking questions to identify transgender and other gender minority respondents on population-based surveys. In: The Williams Institute, ed. Los Angeles; 2014.

  13. Sausa LA, Sevelius J, Keatley J, Iñiquez JR, Reyes M. Policy recommendations for inclusive data collection of trans people in HIV prevention, care, & services. San Francisco: Center of Excellence for Transgender HIV Prevention, University of California, San Francisco; 2009.

    Google Scholar 

  14. The Joint Commission. The Joint Commission: advancing effective communication, cultural competence, and patient–and family-centered care for the lesbian, gay, bisexual and transgender (LGBT) community: a field guide. Oak Brook; 2011.

  15. Peitzmeier SM, Khullar K, Reisner SL, Potter J. Pap test use is lower among female-to-male patients than non-transgender women. Am J Prev Med. 2014;47(6):808–12.

    Article  PubMed  Google Scholar 

  16. • Peitzmeier SM, Reisner SL, Harigopal P, Potter J. Female-to-male patients have high prevalence of unsatisfactory Paps compared to non-transgender females: implications for cervical cancer screening. J Gen Intern Med. 2014;29(5):778–84. This single institution study compares the cervical cancer screening tests performed for female-to-male/transmasculine individuals to non-transgender females and describes the pathological outcomes including the relationship between testosterone use and test adequacy

    Article  PubMed  PubMed Central  Google Scholar 

  17. •• Potter J, Peitzmeier SM, Bernstein I, Reisner SL, Alizaga NM, Agenor M, et al. Cervical cancer screening for patients on the female-to-male spectrum: a narrative review and guide for clinicians. J Gen Intern Med. 2015;30:1857–64. An important qualitative discussion based on clinical interactions with transmascuine individuals that will help gynecological and reproductive health providers provide gender neutral care with a sensitivity regarding transgender experiences

    Article  PubMed  PubMed Central  Google Scholar 

  18. Scheim AI, Bauer GR. Sex and gender diversity among transgender persons in Ontario, Canada: results from a respondent-driven sampling survey. J Sex Res. 2014;52:1–14.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Obedin-Maliver J, de Haan G. Gynecologic care for transgender patients. In: Unger C, ed. Comprehensive care of the transgender patient. Philadelphia: Elsevier. 2017.

  20. Movement Advancement Project (MAP) “Equality maps; identity document laws and policies” 2016;Pages http://www.lgbtmap.org/equality-maps/identity_document_laws on 30 Aug 2016.

  21. Feldman J, Spencer K. Medical and surgical management of the transgender patient: what the primary care clinician needs to know. In: Makadon HMK, Potter J, Goldhammer H, editors. Fenway guide to lesbian, gay, bisexual and transgender health. 2nd ed. Philadelphia: American College of Physicians; 2015. p. 479–511.

    Google Scholar 

  22. Newfield E, Hart S, Dibble S, Kohler L. Female-to-male transgender quality of life. Qual Life Res. 2006;15(9):1447–57.

    Article  PubMed  Google Scholar 

  23. White Hughto JM, Reisner SL. A systematic review of the effects of hormone therapy on psychological functioning and quality of life in transgender individuals. Transgender Health. 2016;1(1):31.

    Article  Google Scholar 

  24. • The World Professional Association for Transgender Health. Standards of care for the health of transsexual, transgender, and gender-nonconforming people. Int J Transgenderism. 2011;13(4):165–232. A critical resource for understanding international standards of clinical and professional care for transgender individuals as organized by transgender health professionals

    Google Scholar 

  25. Winter S, Diamond M, Green J, Karasic D, Reed T, Whittle S, et al. Transgender people: health at the margins of society. Lancet. 2016;388(10042):390–400.

    Article  PubMed  Google Scholar 

  26. •• Guidelines for the primary and gender-affirming care of transgender and gender nonbinary people. In: Deutsch MB, ed. 2nd ed. San Francisco: Center of Excellence for Transgender Health-University of California, San Francisco; 2016. An online, peer reviewed set of clinical guidelines to help support primary care for transgender individuals. Diverse topics related to both ensuring general care guidelines meet the needs of transgender individuals and exploring transgender specific health and healthcare needs.

  27. Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, Gooren LJ, Meyer 3rd WJ, Spack NP, et al. Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2009;94(9):3132–54.

    Article  CAS  PubMed  Google Scholar 

  28. Hembree WC. Guidelines for pubertal suspension and gender reassignment for transgender adolescents. Child Adolesc Psychiatr Clin N Am. 2011;20(4):725–32.

    Article  PubMed  Google Scholar 

  29. Weiss E, Green J. Transgender patients care. Am J Obstet Gynecol. 2014;211(2):185–6.

    Article  PubMed  Google Scholar 

  30. American College of Obstetricians and Gynecologists (ACOG). Practice bulletin no. 89: elective and risk-reducing salpingo-oophorectomy. Obstet Gynecol. 2008;111:231–41.

    Article  Google Scholar 

  31. Ergeneli MH, Duran EH, Ozcan G, Erdogan M. Vaginectomy and laparoscopically assisted vaginal hysterectomy as adjunctive surgery for female-to-male transsexual reassignment: preliminary report. Eur J Obstet Gynecol Reprod Biol. 1999;87(1):35–7.

    Article  CAS  PubMed  Google Scholar 

  32. Gurjala AN, Nazerali RS, Salim A, Lee GK. World’s first baby born through natural insemination by father with total phalloplasty reconstruction. Ann Plast Surg. 2016;76(Suppl 3):S179–83.

    Article  CAS  PubMed  Google Scholar 

  33. Nakamura A, Watanabe M, Sugimoto M, Sako T, Mahmood S, Kaku H, et al. Dose-response analysis of testosterone replacement therapy in patients with female to male gender identity disorder. Endocr J. 2013;60(3):275–81.

    Article  CAS  PubMed  Google Scholar 

  34. Pelusi C, Costantino A, Martelli V, Lambertini M, Bazzocchi A, Ponti F, et al. Effects of three different testosterone formulations in female-to-male transsexual persons. J Sex Med. 2014;11(12):3002–11.

    Article  PubMed  Google Scholar 

  35. Light AD, Obedin-Maliver J, Sevelius JM, Kerns JL. Transgender men who experienced pregnancy after female-to-male gender transitioning. Obstet Gynecol. 2014;124(6):1120–7.

    Article  CAS  PubMed  Google Scholar 

  36. Deutsch MB, Bhakri V, Kubicek K. Effects of cross-sex hormone treatment on transgender women and men. Obstet Gynecol. 2015;125(3):605–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Ferrero S, Gillott DJ, Venturini PL, Remorgida V. Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review. Reprod Biol Endocrinol. 2011;9:89.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Amsterdam LL, Gentry W, Jobanputra S, Wolf M, Rubin SD, Bulun SE. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril. 2005;84(2):300–4.

    Article  CAS  PubMed  Google Scholar 

  39. Ailawadi RK, Jobanputra S, Kataria M, Gurates B, Bulun SE. Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. Fertil Steril. 2004;81(2):290–6.

    Article  CAS  PubMed  Google Scholar 

  40. Jarrell JF, Vilos GA, Allaire C, Burgess S, Fortin C, Gerwin R, et al. Consensus guidelines for the management of chronic pelvic pain. J Obstet Gynaecol Can. 2005;27(9):869–910.

    Article  PubMed  Google Scholar 

  41. Abercrombie PD, Learman LA. Providing holistic care for women with chronic pelvic pain. J Obstet Gynecol Neonatal Nurs. 2012;41(5):668–79.

    Article  PubMed  Google Scholar 

  42. Miller-Matero LR, Saulino C, Clark S, Bugenski M, Eshelman A, Eisenstein D. When treating the pain is not enough: a multidisciplinary approach for chronic pelvic pain. Arch Womens Ment Health. 2015;

  43. Obedin-Maliver J, Light A, de Haan G, Jackson RA. Feasibility of vaginal hysterectomy for female-to-male transgender men. Obstet Gynecol. 2017;129(3):457–63.

    Article  PubMed  Google Scholar 

  44. Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. Menopause. 2013;20(9):888–902; quiz 3–4.

  45. Grynberg M, Fanchin R, Dubost G, Colau JC, Bremont-Weil C, Frydman R, et al. Histology of genital tract and breast tissue after long-term testosterone administration in a female-to-male transsexual population. Reprod BioMed Online. 2010;20(4):553–8.

    Article  CAS  PubMed  Google Scholar 

  46. Miller N, Bedard YC, Cooter NB, Shaul DL. Histological changes in the genital tract in transsexual women following androgen therapy. Histopathology. 1986;10(7):661–9.

    Article  CAS  PubMed  Google Scholar 

  47. Perrone AMCS, Maria Salfi NC, Ceccarelli C, De Giorgi LB, Formelli G, Casadio P, Ghi T, Pelusi G, Pelusi C, Meriggiola MC. Effect of long-term testosterone administration on the endometrium of female-to-male (FtM) transsexuals. J Sex Med. 2009;6(11):3193–200.

    Article  CAS  PubMed  Google Scholar 

  48. Kao A, Binik YM, Kapuscinski A, Khalife S. Dyspareunia in postmenopausal women: a critical review. Pain Res Manag. 2008;13(3):243–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Obedin-Maliver J. Pelvic pain and persistent menses in transgender men. In: Deutsch MB, editor. Guidelines for the primary and gender-affirming care of transgender and gender nonbinary people. 2nd ed. San Francisco: Center of Excellence for Transgender Health, Department of Family and Community Medicine, University of California San Francisco; 2016.

    Google Scholar 

  50. Weber MA, Kleijn MH, Langendam M, Limpens J, Heineman MJ, Roovers JP. Local oestrogen for pelvic floor disorders: a systematic review. PLoS One. 2015;10(9):e0136265.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Dorr MB, Nelson AL, Mayer PR, Ranganath RP, Norris PM, Helzner EC, et al. Plasma estrogen concentrations after oral and vaginal estrogen administration in women with atrophic vaginitis. Fertil Steril. 2010;94(6):2365–8.

    Article  CAS  PubMed  Google Scholar 

  52. Santen RJ. Vaginal administration of estradiol: effects of dose, preparation and timing on plasma estradiol levels. Climacteric. 2015;18(2):121–34.

    Article  CAS  PubMed  Google Scholar 

  53. Gooren LJ. Clinical practice. Care of transsexual persons. N Engl J Med. 2011;364(13):1251–7.

    Article  CAS  PubMed  Google Scholar 

  54. Gorton N, Buth J, Spade D. Medical therapy and health maintenance for transgender men: a guide for health care providers. In: Lyon-Martin Women’s Health Services, ed. San Francisco; 2005:89.

  55. Nikolic DV, Djordjevic ML, Granic M, Nikolic AT, Stanimirovic VV, Zdravkovic D, et al. Importance of revealing a rare case of breast cancer in a female to male transsexual after bilateral mastectomy. World J Surg Oncol. 2012;10:280.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Gooren L, Bowers M, Lips P, Konings IR. Five new cases of breast cancer in transsexual persons. Andrologia. 2015.

  57. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology-genetic/familial high-risk assessment: breast and ovarian. Fort Washington: National Comprehensive Cancer Network; 2016. p. 1–105.

    Google Scholar 

  58. Massad LS, Einstein MH, Huh WK, Katki HA, Kinney WK, Schiffman M, et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis. 2013;17(5 Suppl 1):S1–s27.

    Article  PubMed  Google Scholar 

  59. Dizon DS, Tejada-Berges T, Koelliker S, Steinhoff M, Granai CO. Ovarian cancer associated with testosterone supplementation in a female-to-male transsexual patient. Gynecol Obstet Investig. 2006;62(4):226–8.

    Article  Google Scholar 

  60. Hage JJ, Dekker JJ, Karim RB, Verheijen RH, Bloemena E. Ovarian cancer in female-to-male transsexuals: report of two cases. Gynecol Oncol. 2000;76(3):413–5.

    Article  CAS  PubMed  Google Scholar 

  61. Urban RR, Teng NN, Kapp DS. Gynecologic malignancies in female-to-male transgender patients: the need of original gender surveillance. Am J Obstet Gynecol. 2011;204(5):e9–e12.

    Article  PubMed  Google Scholar 

  62. Workowski KA, Bolan GA. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(Rr-03):1–137.

    PubMed  Google Scholar 

  63. Ellis SA, Wojnar DM, Pettinato M. Conception, pregnancy, and birth experiences of male and gender variant gestational parents: it’s how we could have a family. J Midwifery Womens Health. 2014;60:62–9.

    Article  PubMed  Google Scholar 

  64. Cipres D, Seidman D, Cloniger 3rd C, Nova C, O’Shea A, Obedin-Maliver J. Contraceptive use and pregnancy intentions among transgender men presenting to a clinic for sex workers and their families in San Francisco. Contraception. 2016;95:186–9.

    Article  PubMed  Google Scholar 

  65. Bauer GR, Redman N, Bradley K, Scheim AI. Sexual health of trans men who are gay, bisexual, or who have sex with men: results from Ontario, Canada. Int J Transgend. 2013;14(2):66–74.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Gooren LJ, van Trotsenburg MA, Giltay EJ, van Diest PJ. Breast cancer development in transsexual subjects receiving cross-sex hormone treatment. J Sex Med. 2013;10(12):3129–34.

    Article  PubMed  Google Scholar 

  67. Brown GR, Jones KT. Incidence of breast cancer in a cohort of 5,135 transgender veterans. Breast Cancer Res Treat. 2015;149(1):191–8.

    Article  PubMed  Google Scholar 

  68. Carter HB, Albertsen PC, Barry MJ, Etzoni R, Freedland SJ, Greene KL, et al. Early Detection of Prostate Cancer: American Urological Association (AUA) Guideline. American Urological Association; 2013:1–28.

  69. Trum HW, Hoebeke P, Gooren LJ. Sex reassignment of transsexual people from a gynecologist’s and urologist’s perspective. Acta Obstet Gynecol Scand. 2015;94:563–7.

    Article  PubMed  Google Scholar 

  70. Loverro G, Di Naro E, Caringella AM, De Robertis AL, Loconsole D, Chironna M. Prevalence of human papillomavirus infection in a clinic sample of transsexuals in Italy. Sex Transm Infect. 2016;92(1):67–9.

    Article  PubMed  Google Scholar 

  71. Unger CA. Care of the transgender patient: the role of the gynecologist. Am J Obstet Gynecol. 2014;210(1):16–26.

    Article  PubMed  Google Scholar 

  72. Weyers S, De Sutter P, Hoebeke S, Monstrey G, t Sjoen G, Verstraelen H, et al. Gynaecological aspects of the treatment and follow-up of transsexual men and women. Facts Views Vis Obgyn. 2010;2(1):35–54.

    CAS  PubMed  PubMed Central  Google Scholar 

  73. Green N, Hoenigl M, Morris S, Little SJ. Risk behavior and sexually transmitted infections among transgender women and men undergoing community-based screening for acute and early HIV infection in San Diego. Medicine (Baltimore). 2015;94(41):e1830.

    Article  Google Scholar 

  74. Stephens SC, Bernstein KT, Philip SS. Male to female and female to male transgender persons have different sexual risk behaviors yet similar rates of STDs and HIV. AIDS Behav. 2011;15(3):683–6.

    Article  PubMed  Google Scholar 

  75. Horbach SE, Bouman MB, Smit JM, Ozer M, Buncamper ME, Mullender MG. Outcome of vaginoplasty in male-to-female transgenders: a systematic review of surgical techniques. J Sex Med. 2015;12(6):1499–512.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Juno Obedin-Maliver.

Ethics declarations

Conflict of Interest

Juno Obedin-Maliver and Gene de Haan declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Care for the Transgender Patient

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Obedin-Maliver, J., de Haan, G. Gynecologic Care for Transgender Adults. Curr Obstet Gynecol Rep 6, 140–148 (2017). https://doi.org/10.1007/s13669-017-0204-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13669-017-0204-4

Keywords

Navigation