Abstract
Purpose of Review
The purpose of this review is to provide an overview of the surgical complications associated with penile-inversion vaginoplasty surgery as well as the management required to address these complications. We also review common gynecologic problems after penile-inversion vaginoplasty.
Recent Findings
The incidence of reoperation is not low after penile-inversion vaginoplasty with the literature revealing incidence rates as high as 50% in certain cohorts. However, the majority of these reoperations are for cosmesis. Despite these reported complications, most patients “[feel] positive about their genitals” and “would do this operation again” when asked post-operatively.
Summary
Overall, penile-inversion vaginoplasty is a safe procedure, albeit with a high incidence of patients undergoing subsequent treatment or surgery. Most complications are considered minor and can be managed in the outpatient setting. Reoperations are mostly revision surgery for cosmesis. It is important to counsel patients pre-operatively about all of the possible complications that may arise after vaginoplasty. All patients should be surgically optimized to reduce these complications.
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References
A. L. C. de Vries, J. K. McGuire, T. D. Steensma, E. C. F. Wagenaar, T. A. H. Doreleijers, and P. T. Cohen-Kettenis, de Vries, Annelou L C, Jenifer K McGuire, Thomas D Steensma, Eva C F Wagenaar, Theo A H Doreleijers, and Peggy T Cohen-Kettenis, Young adult psychological outcome after puberty suppression and gender reassignment, (2014)134,(4)696–704
Massie JP, Morrison SD, Van Maasdam J, Satterwhite T. Predictors of patient satisfaction and postoperative complications in penile inversion vaginoplasty. Plast Reconstr Surg. 2018;141(6):911e–21e.
Boas SR, Ascha M, Morrison SD, Massie JP, Nolan IT, Shen JK, et al. Outcomes and predictors of revision labiaplasty and clitoroplasty after gender-affirming genital surgery. Plast Reconstr Surg. 2019;144(6):1451–61.
Hage JJ, Karim RB. Abdominoplastic secondary full-thickness skin graft vaginoplasty for male-to-female transsexuals. Plast Reconstr Surg. 1998;101(6):1512–5.
Horbach SER, Bouman MB, Smit JM, Özer M, Buncamper ME, Mullender MG. Outcome of vaginoplasty in male-to-female transgenders: a systematic review of surgical techniques. J Sex Med. 2015;12(6):1499–512.
Salim A, Poh M. Gender-affirming penile inversion vaginoplasty. Clin Plast Surg, W.B. Saunders. 2018;45(3):343–50.
Gaither TW, Awad MA, Osterberg EC, Murphy GP, Romero A, Bowers ML, et al. Postoperative complications following primary penile inversion vaginoplasty among 330 male-to-female transgender patients. J Urol. 2018;199(3):760–5.
Levy JA, Edwards DC, Cutruzzula-Dreher P, McGreen BH, Akanda S, Tarry S, et al. Male-to-female gender reassignment surgery: an institutional analysis of outcomes, short-term complications, and risk factors for 240 patients undergoing penile-inversion vaginoplasty. Urology. 2019;131:228–33.
Cregten-Escobar P, Bouman MB, Buncamper ME, Mullender MG. Subcutaneous mastectomy in female-to-male transsexuals: a retrospective cohort-analysis of 202 patients. J Sex Med. 2012;9(12):3148–53.
Van Der Sluis WB, Bouman MB, Buncamper ME, Pigot GLS, Mullender MG, Meijerink WJHJ. Clinical characteristics and management of neovaginal fistulas after vaginoplasty in transgender women. Obstet Gynecol. 2016;127(6):1118–26.
Buncamper ME, van der Sluis WB, van der Pas RSD, Özer M, Smit JM, Witte BI, et al. Surgical outcome after penile inversion vaginoplasty: a retrospective study of 475 transgender women. Plast Reconstr Surg. 2016;138(5):999–1007.
Kavoussi P. Surgical, radiographic, and endoscopic anatomy of the male reproductive system - ClinicalKey. In: Campbell-Walsh Urology; 2016. p. 498–515.
M. W. Mulholland, K. D. Lillemoe, T. M. Pawlik, G. M. Doherty, H. B. Alam, and G. R. Upchurch, Greenfield’s surgery : scientific principles and practice. 2017.
Hu M, Zielins E, Longaker M, Lorenz HP. Scar prevention, treatment, and revision. In: Plastic Surgery: Volume 1: Principles. p. 196–213.
Hirotsu K, Kannan S, Brian Jiang SI. Treatment of hypertrophic granulation tissue: a literature review. Dermatol Surg, Lippincott Williams and Wilkins. 2019;45(12):1507–16.
Ives GC, et al. Evaluation of BMI as a risk factor for complications following gender-affirming penile inversion vaginoplasty. Plast Reconstr Surg Glob Open. 2019;7(3):e2097.
A. C. of O. and Gynecologists. Committee opinion 750: perioperative pathways: enhanced recovery after surgery. 2018.
Yeung H, Kahn B, Ly BC, Tangpricha V. Dermatologic conditions in transgender populations. Endocrinol Metab Clin N Am, W.B. Saunders. 2019;48(2):429–40.
Robles DT, Berg D. Abnormal wound healing: keloids. Clin Dermatol. 2007;25(1):26–32.
Meltzer T. Vaginoplasty procedures, complications and aftercare | Transgender Care. [Online]. Available: https://transcare.ucsf.edu/guidelines/vaginoplasty. [Accessed: 03-Apr-2020].
Goddard JC, Vickery RM, Qureshi A, Summerton DJ, Khoosal D, Terry TR. Feminizing genitoplasty in adult transsexuals: early and long-term surgical results. BJU Int. 2007;100(3):607–13.
Stanojevic DS, Djordjevic ML, Milosevic A, Sansalone S, Slavkovic Z, Ducic S, et al. Sacrospinous ligament fixation for neovaginal prolapse prevention in male-to-female surgery. Urology. 2007;70(4):767–71.
Ferrando CA. Vaginoplasty complications. Clin Plast Surg, W.B. Saunders. 2018;45(3):361–8.
Calcagno M, et al. Early prolapse of a neovagina created with self-dilatation and treated with sacrospinous ligament suspension in a patient with Mayer-Rokitansky-Küster-Hauser syndrome: a case report. Fertil Steril. 2010;93(1):267.e1–4.
Muir TW, Walters MD. Surgical management of vaginal vault prolapse in a woman with a neovagina and pelvic kidneys. Obstet Gynecol. 2004;104(5 PART 2):1199–201.
Frederick RW, Leach GE. Abdominal sacral colpopexy for repair of neovaginal prolapse in male-to-female transsexuals. Urology. 2004;64(3):580–1.
Neto RR, Hintz F, Krege S, Rübben H, vom Dorp F. Gender reassignment surgery - a 13 year review of surgical outcomes. Int Braz J Urol. 2012;38(1):97–107.
Elfering L, van der Sluis WB, Mermans JF, Buncamper ME. Herpes neolabialis: herpes simplex virus type 1 infection of the neolabia in a transgender woman. Int J STD AIDS. 2017;28(8):841–3.
Bodsworth NJ, Price R, Davies SC. Gonococcal infection of the neovagina in a male-to-female transsexual. Sex Transm Dis. 1994;21(4):211–2.
Liguori G, Trombetta C, Bucci S, de Seta F, de Santo D, Siracusano S, et al. Condylomata acuminata of the neovagina in a HIV-seropositive male-to-female transsexual. Urol Int. 2004;73(1):87–8.
Frieden TR et al. Morbidity and mortality weekly report sexually transmitted diseases treatment guidelines, 2015 Centers for Disease Control and Prevention MMWR editorial and production staff (serials) MMWR editorial board. 2015.
Bollo J, Balla A, Rodriguez Luppi C, Martinez C, Quaresima S, Targarona EM. HPV-related squamous cell carcinoma in a neovagina after male-to-female gender confirmation surgery. Int J STD AIDS. 2018;29(3):306–8.
Wang G, Ferguson D, Ionescu DN, Hoang L, Barrett S, van Niekerk D, et al. HPV-related neovaginal squamous cell carcinoma presenting as lung metastasis after male-to-female gender confirmation surgery. Case Rep Oncol. 2020;13:17–22.
De Haseth KB, et al. Symptomatic neovaginal candidiasis in transgender women after penile inversion vaginoplasty: a clinical case series of five consecutive patients. Transgender Health. 2018;3(1):105–8.
Weyers S, Verstraelen H, Gerris J, Monstrey S, dos Santos Lopes Santiago G, Saerens B, et al. Microflora of the penile skin-lined neovagina of transsexual women. BMC Microbiol. 2009;9:102.
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Chang, O.H. Care of the Post-vaginoplasty Patient: Management of Complications and Common Gynecologic Issues. Curr Obstet Gynecol Rep 9, 120–128 (2020). https://doi.org/10.1007/s13669-020-00290-0
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DOI: https://doi.org/10.1007/s13669-020-00290-0