Abstract
In the current study we focus on the modeling of functional processes of brain tissue using functional Magnetic Resonance Imaging (fMRI) data. A brain connectivity analysis of Restless Legs Syndrome (RLS) is presented. Thirteen un-medicated patients with late-onset RLS and six healthy subjects are studied using structural and functional brain images. We compare functional connectivity analysis methods, according to their dependency on models or data, as well as to model effective connectivity. An Independent Component Analysis (ICA) method is implemented and all spontaneously activated areas in resting-state condition in both patients and healthy subjects are recorded and be compared with previous studies. Functional connectivity correlation matrices of both RLS and control subjects are extracted and these functional connectivity measures were compared using a seed-based analysis method. We model the brain tissue, based on the influence that one region exerts over another, using a spectral Dynamic Causal Model (DCM) analysis, which has not yet been implemented for RLS data. Finally, a Bayesian Model Selection is chosen in order to compare the winning model that effectively describes the data. The benefits of each methodology are presented.
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References
Martinez, D., Lenz, M.D.C.S.: Sleep-related movement disorders. Sleep Sci. 1(1), 6–14 (2008)
Ku, J., Cho, Y.W., Lee, Y.S., Moon, H.J., Chang, H., Earley, C.J., Allen, R.P.: Functional connectivity alternation of the thalamus in restless legs syndrome patients during the asymptomatic period: a resting-state connectivity study using functional magnetic resonance imaging. Sleep Med. 15(3), 289–294 (2014)
Chang, Y., Chang, H.W., Song, H., Ku, J., Earley, C.J., Allen, R.P., Cho, Y.W.: Gray matter alteration in patients with restless legs syndrome: a voxel-based morphometry study. Clin. Imaging 39(1), 20–25 (2015)
Haba-Rubio, J., Staner, L., Petiau, C., Erb, G., Schunck, T., Macher, J.P.: Restless legs syndrome and low brain iron levels in patients with haemochromatosis. J. Neurol. Neurosurg. Psychiatry 76(7), 1009–1010 (2005)
Li, X., Allen, R.P., Earley, C.J., Liu, H., Cruz, T.E., Edden, R.A., van Zijl, P.C.: Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla. Sleep Med. 22, 75–82 (2016)
Lin, C.C., Fan, Y.M., Lin, G.Y., Yang, F.C., Cheng, C.A., Lu, K.C., Lee, J.T., et al.: 99mTc-TRODAT-1 SPECT as a potential neuroimaging biomarker in patients with restless legs syndrome. Clin. Nucl. Med. 41(1), e14–e17 (2016)
Huettel, S.A., Song, A.W., McCarthy, G.: Functional Magnetic Resonance Imaging, vol. 1. Sinauer Associates, Sunderland (2004)
Ogawa, S., Lee, T.M., Kay, A.R., Tank, D.W.: Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc. Nat. Acad. Sci. 87(24), 9868–9872 (1990)
Smith, S.M., Matthews, P.M., Jezzard, P. (eds.): Functional MRI: An Introduction to Methods. Oxford University Press (2001)
Tripoliti, E.E., Fotiadis, D.I.: Recent developments in computer methods for fMRI data processing. In: Biomedical Engineering. IntechOpen (2009)
Margariti, P., Astrakas, L., Tsouli, S., Hadjigeorgiou, G., Konitsiotis, S., Argyropoulou, M.: Investigation of unmedicated early onset restless legs syndrome by voxel-based morphometry, T2 relaxometry, and functional MR imaging during the night-time hours. Am. J. Neuroradiol. 33(4), 667–672 (2011)
Ku, J., Lee, Y.S., Chang, H., Earley, C.J., Allen, R.P., Cho, Y.W.: Default mode network disturbances in restless legs syndrome/Willis–Ekbom disease. Sleep Med. 23, 6–11 (2016)
Chen, J.E., Glover, G.H.: Functional magnetic resonance imaging methods. Neuropsychol. Rev. 25(3), 289–313 (2015)
Maneshi, M.: Resting-state Functional Connectivity: Methods and Application in Epilepsy (Doctoral dissertation, McGill University Libraries) (2015)
Li, K., Guo, L., Nie, J., Li, G., Liu, T.: Review of methods for functional brain connectivity detection using fMRI. Comput. Med. Imaging Graph. 33(2), 131–139 (2009)
Schurz, M., Wimmer, H., Richlan, F., Ludersdorfer, P., Klackl, J., Kronbichler, M.: Resting-state and task-based functional brain connectivity in developmental dyslexia. Cereb. Cortex 25(10), 3502–3514 (2014)
Van Den Heuvel, M.P., Pol, H.E.H.: Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur. Neuropsychopharmacol. 20(8), 519–534 (2010)
Rosa, M.J., Bestmann, S., Harrison, L., Penny, W.: Bayesian model selection maps for group studies. Neuroimage 49(1), 217–224 (2010)
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Ntemou, A.K., Tripoliti, E.E., Margariti, P.N., Argyropoulou, M.I., Fotiadis, D.I. (2020). Modeling Functional Processes of Brain Tissue: An fMRI Study on Patients with Un-Medicated Late-Onset Restless Leg Syndrome. In: Henriques, J., Neves, N., de Carvalho, P. (eds) XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019. MEDICON 2019. IFMBE Proceedings, vol 76. Springer, Cham. https://doi.org/10.1007/978-3-030-31635-8_37
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DOI: https://doi.org/10.1007/978-3-030-31635-8_37
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