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Increased Growth Velocity and/or Tall Stature

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Endocrine Conditions in Pediatrics

Abstract

Tall stature is defined as linear height above the 97th percentile or more than two standard deviations above the mean for age and sex. While tall stature is most commonly a variant of normal, pathological causes do exist, making recognition by the pediatrician imperative for early diagnosis and treatment. More than a single height measurement enables calculation of growth velocity, or linear growth over time, which provides invaluable information about a child’s overall growth and can be the first clue to pathology. An unexplained acceleration in the growth rate, or a child’s height plotting in a growth percentile much higher than the family height, should prompt careful evaluation. This chapter will review causes of tall stature and increased growth velocity including familial/constitutional tall stature and overgrowth syndromes with a focus on key findings, initial workup, and when to refer to a pediatric endocrinologist. Most children with tall stature but normal growth rate and no concerning findings on history and physical will not require further laboratory evaluation or referral.

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References

  1. Growth Charts - Homepage [Internet]. Centers for Disease Control and Prevention. Centers for Disease Control and Prevention; 2010 [cited 2019Oct14]. Available from: https://www.cdc.gov/growthcharts/index.htm.

  2. Smith DW, Truog W, Rogers JE, Greitzer LJ, Skinner AL, Mccann JJ, et al. Shifting linear growth during infancy: illustration of genetic factors in growth from fetal life through infancy. J Pediatr. 1976;89(2):225–30.

    Article  CAS  Google Scholar 

  3. A health professional’s guide to using growth charts. Paediatr Child Health. 2004;9(3):174–6.

    Google Scholar 

  4. Bowden S, Sotos J, Stratakis C, Weil R. Successful treatment of an invasive growth hormone-secreting pituitary macroadenoma in an 8 year-old boy. J Pediatr Endocrinol Metab. 2007;20(5):643–7.

    Article  CAS  Google Scholar 

  5. Correa R, Salpea P, Stratakis CA. Carney complex: an update. Eur J Endocrinol. 2015;173(4):M85.

    Article  CAS  Google Scholar 

  6. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med. 1994;331(16):1056–61.

    Article  CAS  Google Scholar 

  7. Jones ME, Boon WC, Mcinnes K, Maffei L, Carani C, Simpson ER. Recognizing rare disorders: aromatase deficiency. Nat Clin Pract Endocrinol Metab. 2007;3(5):414–21.

    Article  CAS  Google Scholar 

  8. Sotos JF, Argente J. Overgrowth disorders associated with tall stature. Adv Pediatr. 2008;55(1):213–54.

    Article  Google Scholar 

  9. Davis S, Howell S, Wilson R, Tanda T, Ross J, Zeitler P, et al. Advances in the interdisciplinary care of children with Klinefelter syndrome. Adv Pediatr. 2016;63(1):15–46.

    Article  Google Scholar 

  10. Cambiaso P, Galassi S, Palmiero M, Mastronuzzi A, Bufalo FD, Capolino R, et al. Growth hormone excess in children with neurofibromatosis type-1 and optic glioma. Am J Med Genet A. 2017;173(9):2353–8.

    Article  CAS  Google Scholar 

  11. Hersh JH, Saul RA. Health supervision for children with fragile X syndrome. Pediatrics. 2011;127(5):994–1006.

    Article  Google Scholar 

  12. Ko JM. Genetic syndromes associated with overgrowth in childhood. Ann Pediatr Endocrinol Metabol. 2013;18(3):101.

    Article  Google Scholar 

  13. Hayward C, Brock DJH. Fibrillin-1 mutations in Marfan syndrome and other type-1 fibrillinopathies. Hum Mutat. 1997;10(6):415–23.

    Article  CAS  Google Scholar 

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Correspondence to Pushpa Viswanathan .

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Viswanathan, P., Pinto, B. (2021). Increased Growth Velocity and/or Tall Stature. In: Stanley, T., Misra, M. (eds) Endocrine Conditions in Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-52215-5_2

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  • DOI: https://doi.org/10.1007/978-3-030-52215-5_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-52214-8

  • Online ISBN: 978-3-030-52215-5

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