Abstract
This chapter discusses the interpretation of gonadotropins, gonadal steroids, and other related labs that are used in the assessment of pubertal disorders, atypical genitalia, hyperandrogenism, and hypopituitarism. Understanding the physiology of these hormones during infancy, childhood, and puberty is critical to appropriate interpretation of laboratory results, as is the use of age- and sex-specific reference ranges. Additionally, appreciation of assay limitations, particularly in the case of immunoassays for testosterone, is critical to an appropriate evaluation.
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References
Harrington J, Palmert MR, Hamilton J. Use of local data to enhance uptake of published recommendations: an example from the diagnostic evaluation of precocious puberty. Arch Dis Child. 2014;99(1):15–20.
Fiers T, Wu F, Moghetti P, Vanderschueren D, Lapauw B, Kaufman JM. Reassessing free-testosterone calculation by liquid chromatography-tandem mass spectrometry direct equilibrium dialysis. J Clin Endocrinol Metab. 2018;103(6):2167–74.
Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84(10):3666–72.
Selby C. Sex hormone binding globulin: origin, function and clinical significance. Ann Clin Biochem. 1990;27(Pt 6):532–41.
Coutant R, Biette-Demeneix E, Bouvattier C, Bouhours-Nouet N, Gatelais F, Dufresne S, et al. Baseline inhibin B and anti-Mullerian hormone measurements for diagnosis of hypogonadotropic hypogonadism (HH) in boys with delayed puberty. J Clin Endocrinol Metab. 2010;95(12):5225–32.
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Tobolsky, S., Stanley, T. (2021). Gonadotropins, Gonadal Steroids, SHBG, and Related Labs. In: Stanley, T., Misra, M. (eds) Endocrine Conditions in Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-52215-5_27
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DOI: https://doi.org/10.1007/978-3-030-52215-5_27
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