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Labs Related to Glucose Metabolism and Diabetes

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Endocrine Conditions in Pediatrics

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Abstract

Laboratory evaluation is critical for the diagnosis of diabetes, as well as distinguishing between diabetes subtypes and long-term monitoring of glycemic control. Hemoglobin A1C, fasting plasma glucose, and an oral glucose tolerance test may each be used in the diagnosis of diabetes. The evaluation of autoantibodies, c-peptide, and insulin levels can aid the distinction between type 1 and type 2 diabetes. For long-term management of diabetes, hemoglobin A1c provides an assessment of glycemic control, although it should be interpreted with caution in conditions that affect red blood cell turnover. Evaluating for the presence of ketones is important in settings of hyperglycemia and illness to allow for early detection and prevention of progression to diabetic ketoacidosis.

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References

  1. American Diabetes A. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S13–28.

    Article  Google Scholar 

  2. Goldstein DE, et al. Tests of glycemia in diabetes. Diabetes Care. 2004;27(7):1761–73.

    Article  Google Scholar 

  3. Cowie CC, et al. Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988–2006. Diabetes Care. 2010;33(3):562–8.

    Article  Google Scholar 

  4. Arslanian S, et al. Mel evaluation and management of youth-onset Type 2 diabetes: a position statement by the American Diabetes Association. Diabetes Care. 2018;41(12):2648–68.

    Article  CAS  Google Scholar 

  5. Mayer-Davis EJ, et al. ISPAD clinical practice consensus guidelines 2018: definition, epidemiology, and classification of diabetes in children and adolescents. Pediatr Diabetes. 2018;19(Suppl 27):7–19.

    Article  Google Scholar 

  6. DuBose SN, et al. Obesity in youth with type 1 Diabetes in Germany, Austria, and the United States. J Pediatr. 2015;167(3):627–32 e1-4.

    Article  Google Scholar 

  7. Dabelea D, et al. Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study. Pediatrics. 2014;133(4):e938–45.

    Article  Google Scholar 

  8. American Diabetes A. 13. Children and adolescents: standards of medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S148–64.

    Article  Google Scholar 

  9. Watkins RA, et al. Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review. Transl Res. 2014;164(2):110–21.

    Article  CAS  Google Scholar 

  10. Ziegler AG, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA. 2013;309(23):2473–9.

    Article  CAS  Google Scholar 

  11. Bingley PJ, et al. Type 1 diabetes TrialNet: a multifaceted approach to bringing disease-modifying therapy to clinical use in type 1 diabetes. Diabetes Care. 2018;41(4):653–61.

    Article  CAS  Google Scholar 

  12. Besser RE. Determination of C-peptide in children: when is it useful? Pediatr Endocrinol Rev. 2013;10(4):494–502.

    PubMed  Google Scholar 

  13. Cho MJ, et al. Fasting serum C-peptide is useful for initial classification of diabetes mellitus in children and adolescents. Ann Pediatr Endocrinol Metab. 2014;19(2):80–5.

    Article  Google Scholar 

  14. Katz LE, et al. Fasting c-peptide and insulin-like growth factor-binding protein-1 levels help to distinguish childhood type 1 and type 2 diabetes at diagnosis. Pediatr Diabetes. 2007;8(2):53–9.

    Article  Google Scholar 

  15. Pataky Z, et al. Fasting insulin at baseline influences the number of cardiometabolic risk factors and R-R interval at 3years in a healthy population: the RISC study. Diabetes Metab. 2013;39(4):330–6.

    Article  CAS  Google Scholar 

  16. Staten MA, et al. Insulin assay standardization: leading to measures of insulin sensitivity and secretion for practical clinical care. Diabetes Care. 2010;33(1):205–6.

    Article  CAS  Google Scholar 

  17. Williams Textbook of Endocrinology. 2015: Elsevier.

    Google Scholar 

  18. Welsh KJ, Kirkman MS, Sacks DB. Role of glycated proteins in the diagnosis and management of diabetes: research gaps and future directions. Diabetes Care. 2016;39(8):1299–306.

    Article  CAS  Google Scholar 

  19. Dhatariya K. Blood ketones: measurement, interpretation, limitations, and utility in the management of diabetic ketoacidosis. Rev Diabet Stud. 2016;13(4):217–25.

    Article  Google Scholar 

  20. WHO/IDF, Definitions and diagnosis of diabetes and intermediate hyperglycemia. 2006. Geneva, Switzerland.

    Google Scholar 

  21. Libman IM, et al. Reproducibility of the oral glucose tolerance test in overweight children. J Clin Endocrinol Metab. 2008;93(11):4231–7.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Massachusetts General Hospital for Children, Boston, MA, USA

    Rachel Whooten

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  1. Rachel Whooten
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Correspondence to Rachel Whooten .

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Editors and Affiliations

  1. Division of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Takara Stanley

  2. Division of Pediatric Endocrinology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Madhusmita Misra

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Whooten, R. (2021). Labs Related to Glucose Metabolism and Diabetes. In: Stanley, T., Misra, M. (eds) Endocrine Conditions in Pediatrics. Springer, Cham. https://doi.org/10.1007/978-3-030-52215-5_30

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  • DOI: https://doi.org/10.1007/978-3-030-52215-5_30

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-52214-8

  • Online ISBN: 978-3-030-52215-5

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