Abstract
Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly challenging to study the molecular mechanisms at the basis of these tumors, and to date we are still lacking accurate targets for prevention and therapy. The Notch signaling is involved in a variety of tumorigenic mechanisms, such as regulation of the tumor microenvironment, aberrant intercellular communication, and altered metabolism. Here, we provide an up-to-date review of the role of Notch in head and neck cancer and draw parallels with other types of solid tumors where the Notch pathway plays a crucial role in emergence, maintenance, and progression of the disease. We therefore give a perspective view on the importance of the pathway in neoplastic development in order to define future lines of research and novel therapeutic approaches.
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Abbreviations
- ADAM:
-
A disintegrin and metalloproteinase
- AKT:
-
Protein kinase B
- APC:
-
Adenomatous polyposis coli
- CAF:
-
Cancer-associated fibroblast
- CCL:
-
Chemokine (C-C motif) ligand
- CCND1:
-
Cyclin D1
- cK:
-
Cytokeratin
- COX2:
-
Cyclooxygenase-2
- CRC:
-
Colorectal cancer
- CSC:
-
Cancer stem cell
- CXCL:
-
CXC chemokine ligand
- CXCR:
-
CXC chemokine receptor
- DC:
-
Dendritic cells
- DLL:
-
Delta-like
- EGF(R):
-
Epidermal growth factor (receptor)
- EMT:
-
Epithelial-to-mesenchymal transition
- FBXW7:
-
F-box and WD repeat domain containing 7
- GSI DAPT:
-
Gamma-secretase inhibitors
- Hes:
-
Hairy and enhancer of split-1
- Hey:
-
Hairy/enhancer-of-split related with YRPW motif protein 1
- HIF1:
-
Hypoxia-inducible factor 1
- HNCs:
-
Head and neck cancers
- HNSCC:
-
Head and neck squamous cell carcinoma
- HPV:
-
Human papillomavirus
- IL:
-
Interleukin
- ILC:
-
Innate lymphoid cell
- LAC:
-
Lung adenocarcinoma
- LNR:
-
Cysteine-rich Lin-12/Notch repeats
- LPS:
-
Lipopolysaccharide
- mAb:
-
Monoclonal antibody
- MALM:
-
Mastermind-like
- MET:
-
Mesenchymal-to-epithelial transition
- MMP:
-
Matrix metalloproteinase
- MMTV:
-
Mouse mammary tumor virus
- NCR:
-
Natural cytotoxicity receptor
- NF-κB:
-
Nuclear factor kappa-light-chain-enhancer of activated B cells
- NICD:
-
Notch intracellular domain
- NK:
-
Natural killer cells
- NLS:
-
Nuclear localizing sequence
- Oct4:
-
Octamer-binding transcription factor 4
- OSCC:
-
Oral squamous cell carcinoma
- PTEN:
-
Phosphatase and tensin homolog
- PI3K:
-
Phosphatidylinositol 3-kinase
- RBPj:
-
Recombination signal binding protein for immunoglobulin kappa J region
- SCC:
-
Squamous cell carcinoma
- Shh:
-
Sonic hedgehog
- Sox2:
-
Sex-determining region Y-box 2
- STAT:
-
Signal transducer and activator of transcription
- TAMs:
-
Tumor-associated macrophages
- T-ALL:
-
T-cell acute lymphoblastic leukemia
- TCF:
-
T-cell factor
- TGFβ:
-
Transforming growth factor-β
- TLR:
-
Toll-like receptor
- TNFα:
-
Tumor necrosis factor alpha
- VEGF(R):
-
Vascular endothelial growth factor (receptor)
- α-SMA:
-
α-Smooth muscle actin
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Acknowledgments
CP and TAM were supported by the UZH (University of Zurich). CP is a recipient of the Olga Mayenfisch Stiftung grant. The author would like to thank Christian Thomas Meisel and Alexandra Rose Noble for constructive criticism on the manuscript.
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The authors declared no conflicts of interest with respect to the research, authorship, and/or publication of this article.
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Porcheri, C., Mitsiadis, T.A. (2021). Notch in Head and Neck Cancer. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1287. Springer, Cham. https://doi.org/10.1007/978-3-030-55031-8_7
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