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Notch Signaling and Human Papillomavirus–Associated Oral Tumorigenesis

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Notch Signaling in Embryology and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1287))

Abstract

The NOTCH pathway is critical for the development of many cell types including the squamous epithelium lining of cutaneous and mucosal surfaces. In genetically engineered mouse models, Notch1 acts as one of the first steps to commit basal keratinocytes to terminally differentiate. Similarly, in human head and neck squamous cell cancers (HNSCCs), NOTCH1 is often lost consistent with its essential tumor-suppressive role for initiating keratinocyte differentiation. However, constitutive NOTCH1 activity in the epithelium results in expansion of the spinous keratinocyte layers and impaired terminal differentiation is consistent with the role of NOTCH1 as an oncogene in other cancers, especially in T-cell acute lymphoblastic leukemia. We have previously observed that NOTCH1 plays a dual role as both a tumor suppressor and oncogene, depending on the mutational context of the tumor. Namely, gain or loss or NOTCH1 activity promotes the development of human papillomavirus (HPV)–associated cancers. The additional HPV oncogenes likely disrupt the tumor-suppressive activities of NOTCH and enable the oncogenic pathways activated by NOTCH to promote tumor growth. In this review, we detail the role of NOTCH pathway in head and neck cancers with a focus on HPV-associated cancers.

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Change history

  • 08 December 2020

    Unfortunately the book was published without correcting a typo in the author name in chapter 8. The author name has been corrected now to read as follows:

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Funding

Burroughs Wellcome Career Award for Medical Scientists 1010964 (M.T.S.); NIH/NIDCR R01DE027445-01 (M.T.S.).

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Authors and Affiliations

  1. Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA

    Trinath Das, Rong Zhong & Michael T. Spiotto

  2. Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Michael T. Spiotto

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  1. Trinath Das
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Correspondence to Michael T. Spiotto .

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  1. Department of Dermatology, Saarland University Medical Center, Homburg, Saarland, Germany

    Jörg Reichrath

  2. Department of Dermatology, Saarland University Medical Center, Homburg, Saarland, Germany

    Sandra Reichrath

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Das, T., Zhong, R., Spiotto, M.T. (2021). Notch Signaling and Human Papillomavirus–Associated Oral Tumorigenesis. In: Reichrath, J., Reichrath, S. (eds) Notch Signaling in Embryology and Cancer. Advances in Experimental Medicine and Biology, vol 1287. Springer, Cham. https://doi.org/10.1007/978-3-030-55031-8_8

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