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Trait Interindividual Differences in the Effectiveness of Modafinil

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Advances in Safety Management and Human Performance (AHFE 2021)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 262))

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Abstract

Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity.

Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pressure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up.

Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed.

Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

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Author information

Authors and Affiliations

  1. VIPER Research Unit, LIFE Department, Royal Military Academy, Brussels, Belgium

    Jeroen Van Cutsem, Emilie Dessy, Martine Van Puyvelde, Olivier Mairesse, Xavier Neyt & Nathalie Pattyn

  2. Human Physiology and Sports Physiotherapy Research Group, Vrije Universiteit Brussel, Brussels, Belgium

    Jeroen Van Cutsem & Nathalie Pattyn

  3. Brain Body and Cognition Research Group, Department of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium

    Emilie Dessy, Martine Van Puyvelde & Olivier Mairesse

  4. Clinical and Lifespan Psychology, Department of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium

    Martine Van Puyvelde

  5. Sleep Laboratory and Unit for Chronobiology U78, Brugmann University Hospital, Free University of Brussels-Université Libre de Bruxelles, Brussels, Belgium

    Olivier Mairesse

Authors
  1. Jeroen Van Cutsem
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  2. Emilie Dessy
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  3. Martine Van Puyvelde
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  4. Olivier Mairesse
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  5. Xavier Neyt
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  6. Nathalie Pattyn
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Editor information

Editors and Affiliations

  1. DPS, School of Engineering, University of Minho, Guimarães, Portugal

    Pedro M. Arezes

  2. Idaho National Laboratory, Idaho Falls, ID, USA

    Ronald L. Boring

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Van Cutsem, J., Dessy, E., Van Puyvelde, M., Mairesse, O., Neyt, X., Pattyn, N. (2021). Trait Interindividual Differences in the Effectiveness of Modafinil. In: Arezes, P.M., Boring, R.L. (eds) Advances in Safety Management and Human Performance. AHFE 2021. Lecture Notes in Networks and Systems, vol 262. Springer, Cham. https://doi.org/10.1007/978-3-030-80288-2_2

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  • DOI: https://doi.org/10.1007/978-3-030-80288-2_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80287-5

  • Online ISBN: 978-3-030-80288-2

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