Abstract
Onycholysis is a form of nail toxicity where the nail detaches from the nail bed. This medical condition is reported to appear with up to 44% of the patients undergoing a taxanes based chemotherapy. Frozen gloves can be effective in preventing nail toxicity as they enable cold-induced vasoconstriction (CIVC), or reduction of blood flow, and therefore limits the transport of chemotherapeutic agents towards the nail bed. Unfortunately, the use of frozen gloves also results in cold-induced vasodilation (CIVD), which increases blood flow and reduces the effectiveness of the preventive treatment. Moreover, the gloves induce pain and additional distress during a cancer treatment. The objective of this article is to examine the usefulness of an active local cooling device for controlling blood flow in the fingertips and reducing CIVD, while limiting pain and discomfort. Three different cooling strategies are evaluated for comparing their cooling effectiveness.
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References
Minisini, A.M., et al.: Taxane-induced nail changes: incidence, clinical presentation and outcome. Ann. Oncol. 14(2), 333–337 (2003)
Bladt, L., et al.: Cold-induced vasoconstriction for preventing onycholysis during cancer treatment. Extrem. Physiol. Med. 4(1), A60 (2015)
Hussain, S., Anderson, D.N., Salvatti, M.E., Adamson, B., McManus, M., Braverman, A.S.: Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature. Cancer 88(10), 2367–2371 (2000)
Robert, C., et al.: Nail toxicities induced by systemic anticancer treatments. Lancet Oncol. 16(4), e181–e189 (2015)
Kadakia, K.C., Rozell, S.A., Butala, A.A., Loprinzi, C.L.: Supportive cryotherapy: a review from head to toe. J. Pain Symptom Manage. 47(6), 1100–1115 (2014)
Tyler, C.J., Reeve, T., Cheung, S.S.: Cold-induced vasodilation during single digit immersion in 0°C and 8°C water in men and women. PLoS ONE 10(4), 1–13 (2015)
Daanen, H.A.M.: Finger cold-induced vasodilation: a review. Eur. J. Appl. Physiol. 89(5), 411–426 (2003)
Scotté, F., et al.: Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. J. Clin. Oncol. 23(19), 4424–4429 (2005)
Steckel, J., et al.: A research platform using active local cooling directed at minimizing the blood flow in human fingers. In: Proceedings of the ICTs Improving Patients Rehabilitation Research Techniques, pp. 81–84 (2013)
Scotté, F., et al.: Matched case-control phase 2 study to evaluate the use of a frozen sock to prevent docetaxel-induced onycholysis and cutaneous toxicity of the foot. Cancer 112(7), 1625–1631 (2008)
Can, G., Aydiner, A., Cavdar, I.: Taxane-induced nail changes: predictors and efficacy of the use of frozen gloves and socks in the prevention of nail toxicity. Eur. J. Oncol. Nurs. 16(3), 270–275 (2012)
Sawada, S., Araki, S., Yokoyama, K.: Changes in cold-induced vasodilatation, pain and cold sensation in fingers caused by repeated finger cooling in a cool environment. Ind. Health 38, 79–86 (2000)
D’Haene, M., Youssef, A., De Bruyne, G., Aerts, J.-M.: Modelling and controlling blood flow by active cooling of the fingers to prevent nail toxicity, Thesis. KU Leuven, Belgium, November, p. 89 (2015)
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Aernouts, T., De Boeck, M., Vleugels, J., Peeters, M., De Bruyne, G. (2019). A Cryotherapeutic Device for Preventing Nail Toxicity During Chemotherapy: Comparison of Three Cooling Strategies. In: Lightner, N. (eds) Advances in Human Factors and Ergonomics in Healthcare and Medical Devices. AHFE 2018. Advances in Intelligent Systems and Computing, vol 779. Springer, Cham. https://doi.org/10.1007/978-3-319-94373-2_4
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DOI: https://doi.org/10.1007/978-3-319-94373-2_4
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