Skip to main content
SpringerLink
Log in

Dehydroepiandrosterone Administration as a Prophylaxis Against Acute Stress Reactivity in Military Personnel

  • Conference paper
  • First Online:
Advances in Human Error, Reliability, Resilience, and Performance (AHFE 2018)

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 778))

Included in the following conference series:

  • 1050 Accesses

Abstract

Stress in an inherent part of military operations that can impair or even compromise the readiness of military forces. Recent demands for multiple deployments amplify service member stress through family separation, chaos of the battlefield, and facing the death and injury of fellow-service members, and risks of the same for themselves. Dealing with stress takes a toll physically, emotionally, and morally, and exposure to recurrent and acute stressors may lead to stress-related ailments. In turn, widespread stress-related problems can burden the military health system and degrade the performance and readiness of our forces. Therefore, methods that allow for the successful mitigation and/or prevention of stress are highly desirable. This paper provides a literature review, along with a proposed research concept that would investigate the possibility of utilizing a well-known dietary supplement, DHEA, as a prophylaxis against acute stress for military personnel. Methods for testing this approach and its possible impact are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Thoits, P.A.: Stress and health: major findings and policy implication. J. Health Soc. Behav. 87, 54–58 (2010)

    Google Scholar 

  2. McEwen, B.S.: Protection and damage from acute stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. N. Y. Acad. Sci. 1032, 1–7 (2004)

    Article  Google Scholar 

  3. Bray, R.M., Camlin, C.S., Fairbank, J.A., Dunteman, G.H., Wheeless, S.C., Dunteman, G.H.: The effects of stress on job functioning of military men and women. Armed Forces Soc. 27, 397–417 (2001)

    Article  Google Scholar 

  4. Klein, A., Falca-Dodson, M., Sussner, B., Ciccone, D.S., Chandler, H., Callahan, L., Losonczy, M.: Effects of repeated deployment to Iraq and Afghanistan on the health of New Jersey Army National Guard troops: implications for military readiness. Am. J. Public Health 100, 276–283 (2010)

    Article  Google Scholar 

  5. Lupien, S.J., McEwen, B.S., Gunnar, M.R., Heim, C.: Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat. Rev. Neurosci. 10, 434–445 (2009)

    Article  Google Scholar 

  6. Schumm, J.A., Chard, K.M.: Alcohol and stress in the military. Alcohol Res. Curr. Rev. 34, 401–407 (2012)

    Google Scholar 

  7. Bryan, C., Clemans, T.A., Leeson, B., Rudd, M.D.: Acute vs. chronic stressors, multiple suicide attempts, and persistent suicide ideation in US soldiers. J. Nerv. Mental Dis. 203, 48–53 (2015)

    Article  Google Scholar 

  8. Institute of Medicine: Treatment for Posttraumatic Stress Disorder in Military Veteran Populations: Initial Assessment. National Academies Press, Washington DC (2012)

    Google Scholar 

  9. Cannon, W.B.: The emergency function of the adrenal medulla in pain and the major emotions. Am. J. Physiol. 33, 356–372 (1914)

    Google Scholar 

  10. Bracha, H.S., Ralston, T.C., Matsukawa, J.M., Williams, A.E., Bracha, A.S.: Does “fight or flight” need updating? Psychosomatics 45, 448–449 (2004)

    Article  Google Scholar 

  11. Tsigos, C., Chrousos, G.P.: Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J. Psychosom. Med. 53, 865–871 (2002)

    Article  Google Scholar 

  12. Hellhammer, D.H., Wust, S., Kudielka, B.M.: Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology 34, 163–171 (2009)

    Article  Google Scholar 

  13. Vgontzas, A.N., Bixler, E.O., Lin, H.M., Prolo, P., Mastorakos, G., Vela-Bueno, A., Kales, A., Chrousos, G.P.: Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J. Clin. Endocrinol. Metab. 86, 3787–3794 (2001)

    Article  Google Scholar 

  14. Padgett, D.A., Glaser, R.: How stress influences the immune response. Trends Immunol. 24, 444–448 (2003)

    Article  Google Scholar 

  15. Sephton, S.E., Sapolsky, R.M., Kraemer, H.C., Spiegel, D.: Diurnal cortisol rhythm as a predictor of breast cancer survival. J. Natl. Cancer Inst. 92, 994–1000 (2000)

    Article  Google Scholar 

  16. Sephton, S.E., Lush, E., Dedert, E.A., Floyd, A.R., Rebholz, W.N., Dhabhar, F.S., Spiegel, D., Salmon, P.: Diurnal cortisol rhythm as a predictor of lung cancer survival. Brain Behav. Immun. 30, S163–S170 (2013)

    Article  Google Scholar 

  17. Wang, D.Y., Bulbrook, R.D., Sneddon, A., Hamilton, T.: The metabolic clearance rates of dehydroepiandrosterone and their sulphate esters in man, rat and rabbit. J. Endocri nol. 38, 307–318 (1967)

    Article  Google Scholar 

  18. Nussey, S., Whitehead, S.: Endocrinology: An Integrated Approach. BIOS Scientific Publishers, Oxford (2001)

    Book  Google Scholar 

  19. Grillon, C., Pine, D.S., Baas, J.M.P., Lawley, M., Ellis, V., Charney, D.S.: Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humans. Psychopharmacology 186, 434–441 (2006)

    Article  Google Scholar 

  20. Kroboth, P.D., Salek, F.S., Pittenger, A.L., Fabian, T.J., Frye, R.F.: DHEA and DHEA-S: a review. J. Clin. Pharmacol. 39, 327–348 (1999)

    Article  Google Scholar 

  21. Kimonides, V.G., Khatibi, N.H., Svendsen, C.N., Sofroniew, M.V., Herbert, J.: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc. Natl. Acad. Sci. 95, 1852–1857 (1998)

    Article  Google Scholar 

  22. Lur, G., Rakos, G., Juhasz-Vedres, G., Farkas, T., Kis, Z., Toldi, J.: Effects of dehydroepiandrosterone on the evoked cortical activity of controls and of brain-injured rats. Cell. Mol. Neurobiol. 26, 1505–1519 (2006)

    Article  Google Scholar 

  23. Fleshner, M., Pugh, C.R., Trembley, D., Rudy, J.W.: DHEA-S selectively impairs contextual-fear conditioning: support for the antiglucocorticoid hypothesis. Behav. Neurosci. 111, 512–517 (1997)

    Article  Google Scholar 

  24. Maninger, N., Wolkowitz, O.M., Reus, V.I., Epel, E.S., Mellon, S.H.: Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front. Neuroendocrinol. 30, 1–7 (2009)

    Article  Google Scholar 

  25. Alhaj, H.A., Massey, A.E., McAllister-Williams, R.H.: Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study. Psychopharmacologia 188, 541–551 (2006)

    Article  Google Scholar 

  26. Lennartsson, A.K., Kushnir, M.M., Bergquist, J., Jonsdottir, I.H.: DHEA and DHEA-S response to acute psychosocial stress in healthy men and women. Biol. Psychol. 90, 143–149 (2012)

    Article  Google Scholar 

  27. Gallagher, P., Leitch, M., Massey, A., McAllister-Williams, R., Young, A.: Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection method. J. Psychopharmacol. 20, 643–649 (2006)

    Article  Google Scholar 

  28. Phillips, A.C., Carroll, D., Gale, C.R., Lord, J.M., Arlt, W., Batty, G.D.: Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam experience study. Eur. J. Endocrinol. 163, 285–292 (2010)

    Article  Google Scholar 

  29. Phillips, A.C., Carroll, D., Gale, C.R., Lord, J.M., Arlt, W., Batty, G.D.: Cortisol, DHEA sulphate, their ratio, and metabolic syndrome. Eur. J. Endocrinol. 163, 919–923 (2010)

    Article  Google Scholar 

  30. Hoge, E.A., Austin, E.D., Pollack, M.H.: Resilience: research evidence and conceptual considerations for posttraumatic stress disorder. Depress. Anxiety 24, 139–152 (2007)

    Article  Google Scholar 

  31. Taylor, M.K., Sausen, K.P., Potterat, E.G., Mujica-Parodi, L.R., Reis, J.P., Markham, A.E., Padilla, G.A., Taylor, D.L.: Stressful military training: endocrine reactivity, performance, an psychological impact. Aviat. Space Environ. Med. 78, 1143–1149 (2007)

    Article  Google Scholar 

  32. Charney, D.S.: Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am. J. Psychiatry 161, 195–216 (2004)

    Article  Google Scholar 

  33. Mahan, A.L., Ressler, K.J.: Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci. 35, 24–35 (2012)

    Article  Google Scholar 

  34. Grillon, C., Morgan, C.A.: Fear-potentiated startle conditioning to explicit and contextual cues in Gulf War veterans with posttraumatic stress disorder. J. Abnorm. Psychol. 108, 134–142 (1999)

    Article  Google Scholar 

  35. Jackson, E.D., Payne, J.D., Nadel, L., Jacobs, W.J.: Stress differentially modulates fear conditioning in healthy men and women. Biol. Psychiat. 59, 516–522 (2006)

    Article  Google Scholar 

  36. Pugh, C., Tremblay, D., Fleshner, M., Rudy, J.: A selective role for corticosterone in con textual-fear conditioning. Behav. Neurosci. 111, 503–511 (1997)

    Article  Google Scholar 

  37. Cordero, M., Venero, C., Kruyt, N., Sandi, C.: Prior exposure to a single stress session facilitates subsequent contextual fear conditioning in rats: evidence for a role of corticosterone. Horm. Behav. 44, 338–345 (2003)

    Article  Google Scholar 

  38. Obut, T.A., Ovsyukova, M.V., Cherkasova, O.P.: Stress-limiting effect of dehydroepiandrosterone sulfate and its mechanism. Bull. Exp. Biol. Med. 135, 231–233 (2003)

    Article  Google Scholar 

  39. Obut, T.A., Ovsyukova, M.V., Cherkasova, O.P.: Prolonged decrease in stress reactivity caused by dehydroepiandrosterone sulfate. Bull. Exp. Biol. Med. 141, 571–573 (2006)

    Article  Google Scholar 

  40. Maayan, R., Touati-Werner, D., Ram, E., Strous, R., Keren, O., Weizman, A.: The protective effect of frontal cortex dehydroepiandrosterone in anxiety and depressive models in mice. Pharmacol. Biochem. Behav. 85, 415–421 (2006)

    Article  Google Scholar 

  41. Alvarez, R.P., Biggs, A., Chen, G., Pine, D.S., Grillon, C.: Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions. J. Neurosci. 28, 6211–6219 (2008)

    Article  Google Scholar 

  42. Morgan, C.A., Wang, S., Mason, J., Southwick, S.M., Fox, P., Hazlett, G., Charney, D.S., Greenfield, G.: Hormone profiles in humans experiencing military survival training. Biol. Psychiat. 47, 891–901 (2000)

    Article  Google Scholar 

  43. Bovenberg, S.A., van Uum, S.H., Hermus, A.R.: Dehydroepiandrosterone administration in humans: evidence based? Neth. J. Med. 63, 300–304 (2005)

    Google Scholar 

  44. Wolf, O.T., Kudielka, B.M., Hellhammer, D.H., Hellhammer, J., Kirschbaum, C.: Opposing effects of DHEA replacement in elderly subjects on declarative memory and attention after exposure to a laboratory stressor. Psychoneuroendocrinology 23, 617–629 (1998)

    Article  Google Scholar 

  45. Straub, R.H., Konecna, L., Hrach, S., Rothe, G., Kreutz, M., Scholmerich, J., Falk, W., Lang, B.: Serum dehydroepiandrosterone (DHEA) and DHEAS sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J. Endocrinol. Metab. 83, 2012–2017 (1998)

    Article  Google Scholar 

  46. Cardounel, A., Regelson, W., Kalimi, M.: Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: mechanism of action. Exp. Biol. Med. 222, 145–149 (1999)

    Article  Google Scholar 

  47. Morgan, C.A., Southwick, S., Hazlett, G., Rasmusson, A., Hoyt, G., Zimolo, Z., Charney, D.: Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed to acute stress. Arch. Gen. Psychiat. 61, 819–825 (2004)

    Article  Google Scholar 

  48. Morgan, C.A., Rasmusson, A., Pietrzak, R.H., Coric, V., Southwick, S.M.: Relationships among plasma dehydroepiandrosterone sulfate, cortisol, symptoms of dissociation, and objective performance in humans exposed to underwater navigation stress. Biol. Psychiat. 66, 334–340 (2009)

    Article  Google Scholar 

  49. Cohen, S.: Aftereffects of stress on human performance and social behavior: a review of research and theory. Psychol. Bull. 88, 82–108 (1980)

    Article  Google Scholar 

  50. Ellington, C.M., Wright, S.J., Burrell, L.M., Matthews, M.D.: The effects of DHEA on resilience to PTSD. Research report PL488E6. United States Military Academy, West Point (2011)

    Google Scholar 

  51. Watson, P., Litz, B., Southwick, S., Ritchie, E.C.: Preparation for deployment: improving resilience. In: Ritchie, E.C. (eds.). Combating and Operational Behavioral Health. Borden Institute, Fort Detrick (2011)

    Google Scholar 

  52. Zhang, X., Dong, Y.L., Yang, N., Liu, Y.Y., Gao, R.F., Zuo, P.P.: Effects of Ning Shen Ling granule and dehydroepiandrosterone on cognitive function in mice undergoing chronic mild stress. Chin. J. Integr. Med. 13, 46–49 (2007)

    Article  Google Scholar 

  53. Bonnet, S., Dumas-de-La-Roque, E., Bequeret, H., Marthan, R., Fayon, M., Dos Santos, P., Savineau, J.P., Baulieu, E.E.: Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension. Proc. Natl. Acad. Sci. USA 100, 9488–9493 (2003)

    Article  Google Scholar 

  54. Sripada, R.K., Marx, C.E., King, A.P., Rajaram, N., Garfinkel, S.N., Abelson, J.L., Liberzon, I.: DHEA enhances emotion regulation neurocircuits and modulates memory for emotional stimuli. Neuropsychopharmacology 38, 1798–1807 (2013)

    Article  Google Scholar 

  55. Friess, E., Trachsel, L., Guldner, J., Schier, T., Steiger, A., Holsboer, F.: DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. Am. J. Physiol. Endocrinol. Metab. 268, E107–E113 (1995)

    Article  Google Scholar 

  56. Khorram, O., Vu, L., Yen, S.S.C.: Activation of immune function in dehydroepiandrosterone (DHEA) in age-advanced men. J. Gerontol. Ser. A Biol. Med. Sci. 52, M1–M7 (1997)

    Google Scholar 

  57. Kroboth, P.D., Amico, J.A., Stone, R.A., Folan, M., Frye, R.F., Kroboth, F.J., Bigos, K.L., Fabian, T.J., Linares, A.M., Pollock, B.G., Hakala, C.: Influence of DHEA administration on 24-hour cortisol concentrations. J. Clin. Psychopharmacol. 23, 96–99 (2003)

    Article  Google Scholar 

  58. Stangl, B., Hirshman, E., Verbalis, J.: Administration of dehydroepiandrosterone (DHEA) enhances visual-spatial performance in post-menopausal women. Behav. Neurosci. 125, 742–752 (2011)

    Article  Google Scholar 

  59. Wolf, O.T., Koster, B., Kirschbaum, C., Pietrowsky, R., Kern, W., Hellhammer, D.H., Born, J., Fehm, H.L.: A single administration of dehydroepiandrosterone does not enhance memory performance in young healthy adults, but immediately reduces cortisol levels. Biol. Psychiat. 42, 845–848 (1997)

    Article  Google Scholar 

  60. Taylor, M.K., Padilla, G.A., Stanfill, K.E., Markham, A.E., Khosravi, J.Y., Ward, M.D., Koehler, M.M.: Effects of dehydroepiandrosterone supplementation during stressful military training: a randomized, controlled, double-blind field study. Stress 15, 85–96 (2012)

    Article  Google Scholar 

  61. Morgan, B.J., Bibb, S.C.: Assessment of military population-based psychological resilience programs. Mil. Med. 176, 976–985 (2011)

    Article  Google Scholar 

  62. Junqueira de Menezes, K., Peixto, C., Nardi, A.E., Carta, M.G., Machado, S., Veras, A.B.: Dehydroepiandrosterone, its sulfate and cognitive functions. Clin. Pract. Epidemiol. Mental Health 12, 24–37 (2016)

    Google Scholar 

  63. Alhaj, H.A., Massey, A.E., McAllister-Williams, R.H.: Effects of DHEA administration on episodic memory, cortisol, and mood in healthy young men: a double-blind placebo-controlled study. Psychopharmacology 188, 541–551 (2006)

    Article  Google Scholar 

  64. Janelle, C.M., Hatfield, B.D.: Visual attention and brain processes that underlie expert performance: implications for sport and military psychology. Mil. Psychol. 20, S39–S69 (2008)

    Article  Google Scholar 

  65. Crowder, J.A., Friess, S.: Warrior resilience training through cognitive self-regulation. In: Proceedings on the International Conference on Artificial Intelligence (ICAI). The Steering Committee of the World Congress in Computer Science, Computer Engineering and Applied Computing, Athens (2012)

    Google Scholar 

  66. Russo, S.J., Murrough, J.W., Han, M., Charney, D.S., Nestler, E.J.: Neurobiology of resilience. Nat. Neurosci. 15, 1475–1484 (2012)

    Article  Google Scholar 

  67. Kirschbaum, C., Pirke, K.M., Hellhammer, D.H.: The ‘Trier Social Stress Test’ – a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28, 76–81 (1993)

    Article  Google Scholar 

  68. Schwabe, L., Haddad, L., Schachinger, H.: HPA axis activation by a socially evaluated cold-pressor test. Psychoneuroendocrinology 33, 890–895 (2008)

    Article  Google Scholar 

  69. Lejuez, C.W., Kahler, C.W., Brown, R.A.: A modified computer version of the paced auditory serial addition task (PASAT) as a laboratory-based stressor. Behav. Therapist 26, 290–293 (2003)

    Google Scholar 

  70. Ham, R.M., Mowery, D.C.: Improving the effectiveness of public-private R&D collaboration: case studies at a US weapons laboratory. Res. Policy 26, 661–675 (1998)

    Article  Google Scholar 

  71. Entwistle, T., Martin, S.: From competition to collaboration in public service delivery: a new agenda for research. Public Adm. 83, 233–242 (2005)

    Article  Google Scholar 

  72. Hood, L., Balling, R., Auffray, C.: Revolutionizing medicine in the 21st century through systems approaches. Biotechnol. J. 7, 992–1001 (2012)

    Article  Google Scholar 

  73. Engel, G.L.: The need for a new medical model: a challenge for biomedicine. Science 196, 129–136 (1977)

    Article  Google Scholar 

  74. Crawford, C., Wallerstedt, D.B., Khorsan, R., Clausen, S.S., Jonas, W.B., Walter, J.A.G.: A systematic review of biopsychosocial training programs for the self-management of emotional stress: potential applications for the military. Evid. Based Complement. Altern. Med. 2013, 747694 (2013)

    Google Scholar 

  75. Smeets, T., Dziobek, I., Wolf, O.T.: Social cognition under stress: differential effects of stress-induced cortisol elevations in healthy young men and women. Horm. Behav. 55, 507–513 (2009)

    Article  Google Scholar 

  76. Andrews, G., Tennant, C., Hewson, D.M., Vaillant, G.E.: Life event stress, social support, coping style, and risk of psychological impairment. J. Nerv. Ment. Dis. 166, 307–316 (1978)

    Article  Google Scholar 

  77. Office of the Under Secretary of Defense: The Department of Defense Plan to Achieve the Vision of the DoD Task Force on Mental Health. Defense Health Board, Falls Church Defense Health Board (2007)

    Google Scholar 

  78. Guenthner, D.H.: Emergency and crisis management: critical incident stress management for first responders and business organisations. J. Bus. Continuity Emerg. Plann. 5, 298–315 (2012)

    Google Scholar 

  79. Nash, W.P., Vasterling, J., Ewing-Cobbs, L., Horn, S., Gaskin, T., Golden, J., Riley, W.T., Bowles, S.V., Favret, J., Lester, P., Koffman, R., Farnsworth, L.C., Baker, D.G.: Consensus recommendations for common data elements for operational stress research and surveillance: report of a federal interagency working group. Arch. Phys. Med. Rehabil. 91, 1673–1683 (2010)

    Article  Google Scholar 

  80. Vogt, D., Samper, R., King, D., King, L., Martin, J.: Deployment stressors and posttraumatic stress symptomology: comparing active duty and national guard/reserve personnel from Gulf War I. J. Trauma. Stress 21, 66–74 (2008)

    Article  Google Scholar 

  81. Brandes, D., Ben-Schachar, G., Gilboa, A., Bonne, O., Freedman, S., Shalev, A.: PTSD symptoms and cognitive performance in recent trauma survivors. Psychiatry Res. 110, 231–238 (2002)

    Article  Google Scholar 

  82. Clark, C., McFarlane, A., Morris, P., Weber, D., Sonkkilla, C., Shaw, M., Marcina, J., Tochon-Danguy, H.J., Egan, G.F.: Cerebral function in posttraumatic stress disorder during verbal working memory updating: a positron emission tomography study. Biol. Psychiat. 53, 474–481 (2003)

    Article  Google Scholar 

  83. Qin, S., Hermans, E., van Marle, H., Luo, J., Fernandez, G.: Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex. Biol. Psychiat. 66, 25–32 (2009)

    Article  Google Scholar 

  84. Issakidis, C., Sanderson, K., Corry, J., Andrews, G., Lapsley, H.: Modelling the population cost-effectiveness of current and evidence-based optimal treatment for anxiety disorders. Psychol. Med. 34, 19–35 (2004)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. DCS Corp, Alexandria, VA, USA

    Cory R. Overby

  2. U.S. Army Research Laboratory, HRED-ATSD, Army Medical Department Field Element, Fort Sam Houston, San Antonio, TX, USA

    Valerie Rice

Authors
  1. Cory R. Overby
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Valerie Rice
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Valerie Rice .

Editor information

Editors and Affiliations

  1. Idaho National Laboratory, Idaho Falls, Idaho, USA

    Ronald L. Boring

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer International Publishing AG, part of Springer Nature (outside the USA)

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Overby, C.R., Rice, V. (2019). Dehydroepiandrosterone Administration as a Prophylaxis Against Acute Stress Reactivity in Military Personnel. In: Boring, R. (eds) Advances in Human Error, Reliability, Resilience, and Performance. AHFE 2018. Advances in Intelligent Systems and Computing, vol 778. Springer, Cham. https://doi.org/10.1007/978-3-319-94391-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-94391-6_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94390-9

  • Online ISBN: 978-3-319-94391-6

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation