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Lymph Node Disorders

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Abstract

Enlarged lymph nodes (lymphadenopathy) are frequently a reason to consult the pediatric surgeon. The purpose of this chapter is to describe the various causes and methods to investigate a child with enlarged nodes. The increasingly important role of imaging, but also its limitations, as well as various invasive procedures are discussed.

The main issues for the pediatric surgeon are the indication for biopsy of enlarged nodes, the methods to assess lymph nodes in patients with malignancies and the need for radical lymph node dissection.

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References

  • Attarbaschi A, Mann G, Dworzak M, et al. The role of surgery in the treatment of pediatric B-cell non-Hodgkin’s lymphoma. J Pediatr Surg. 2002;37(10):1470–5.

    Article  Google Scholar 

  • Baek MY, Park KH, We JH, Park SE. Needle aspiration as therapeutic management for suppurative cervical lymphadenitis in children. Korean J Pediatr. 2010;53(8):801–4.

    Article  Google Scholar 

  • Baum SH, Frühwald M, Rahbar K, et al. Contribution of PET/CT to prediction of outcome in children and young adults with rhabdomyosarcoma. J Nucl Med. 2011;52:1535–40.

    Article  CAS  Google Scholar 

  • Cox CM, El-Mallawamy NK, Kabue M, et al. Clinical characteristics and outcomes of HIV-infected children diagnosed with Kaposi sarcoma in Malawi and Botswana. Pediatr Blood Cancer. 2013; https://doi.org/10.1002/pbc.24516.

    Article  Google Scholar 

  • Derese Y, Hailu E, Assefa T, et al. Comparison of PCR with standard culture of fine needle aspiration samples in the diagnosis of tuberculosis lymphadenitis. J Infect Dev Ctries. 2013; 6(1). https://doi.org/10.3855/jidc2050.

  • Dispenzieri A, Armitage JO, Loe MJ, et al. The clinical spectrum of Castleman’s disease. Am J Hematol. 2012;87:99701002.

    Google Scholar 

  • Fanny M-L, Beyam N, Gody JC, et al. Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, central African Republic. BMC Pediatr. 2012;12:191–4.

    Article  Google Scholar 

  • Fischer AC, Mitchell SE, Tufaro AP. Chapter 103. Lymphatic and venous vascular malformation. In: Oldham KT, Colombani PM, Foglia RP, Skinner MA, editors. Principles and practice of pediatric surgery. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 1691–703.

    Google Scholar 

  • Gallois Y, Cogo H, Debuisson C, et al. Nontuberculous lymphadenitis in children: what management strategy? Int J Pediatr Otorhinolaryngol. 2019;122:196–202.

    Article  Google Scholar 

  • Gosche JR, Vick L. Acute, subacute, and chronic cervical lymphadenitis in children. Semin Pediatr Surg. 2006;15:99–106.

    Article  Google Scholar 

  • Gow KW, Rapkin LB, Olson TA, et al. Sentinel node biopsy in the pediatric population. J Pediatr Surg. 2008;43(12):193–8.

    Google Scholar 

  • Han D, Zager JS, Han G, et al. The unique clinical characteristics of melanoma diagnosed in children. Ann Surg Oncol. 2012;19:3888–95.

    Article  Google Scholar 

  • Irira M, Ngocho JS, Youze J, et al. Prevalence and outcome of HIV-associated malignancies among HIV-infected children enrolled into Care at Kilimanjaro Christian Medical Center 2006 to 2014: a hospital-based retrospective analytical study. J Pediatr Hematol Oncol. 2018; https://doi.org/10.1097/MPH.0000000000001389.

    Article  Google Scholar 

  • Iyer VK. Pediatric lymphoma diagnosis (review). Indian J Pediatr. 2013;80:756–83.

    Article  Google Scholar 

  • Karmazyn B, Werner EA, Rejaie B, Applegate KE. Mesenteric lymphnodes in children: what is normal? Pediatr Radiol 2005;35:774–7

    Article  Google Scholar 

  • Lubahn JD, Cost NG, Kwon J, et al. Correlation between preoperative staging computerized tomography and pathological findings after nodal sampling in children with Wilms’ tumor. J Urol. 2012;188(4):1500–5.

    Article  Google Scholar 

  • Ludwig BJ, Wang J, Nadgir RN, et al. Imaging of cervical lymphadenopathy in children and young adults. AJR. 2012;199:1105–13.

    Article  Google Scholar 

  • Mittra P, Bharti R, Pandey MK. Role of FNAC in head and neck lesions in the paediatric age group. J Clin Diagn Res. 2013;7:1055–8.

    PubMed  PubMed Central  Google Scholar 

  • Pandey A, Kureel SN, Pandey J, et al. Chronic cervical lymphadenopathy in children: role of ultrasonography. J Indian Assoc Pediatr Surg. 2012;17(2):58–62.

    Article  Google Scholar 

  • Parikh SR, Sadoughi B, Sin S, et al. Deep cervical lymph node hypertrophy: a new paradigm in the understanding of pediatric obstructive sleep apnea. Laryngoscope. 2013; https://doi.org/10.1002/lary.23748.

    Article  Google Scholar 

  • Rathaus V, Shapiro M, Grunebaum M, Zissin R. Enlarged mesenteric lymph nodes in asymptomatic children: the value of the finding in various imaging modalities. Br J Radiol. 2005;78:30–3.

    Article  CAS  Google Scholar 

  • Razek AA, Gaballa G. Role of perfusion magnetic resonance imaging in cervical lymphadenopathy. J Comput Assist Tomogr 2011;35:21–5

    Article  Google Scholar 

  • Restrepo R, Oneto J, Lopez K, Kukreja K. Head and neck lymph nodes: the spectrum from normal to abnormal. Pediatr Radiol. 2009;39:836–46.

    Article  Google Scholar 

  • Suh JK, Gao YJ, Tang JY, et al. Clinical characteristics and treatment outcomes of pediatric patients with non-Hodgkin lymphoma in East Asia. Cancer Res Treat. 2019; https://doi.org/10.4143/crt.2019.219.

  • Thomas AG, Vaidhyanath R, Kirke R, Rajesh A. Extranodal lymphoma from head to toe: part I, The head and spine. AJR. 2011;197:350–6.

    Article  Google Scholar 

  • Upperman JS, Ford HR. Chapter 14. Inflammation. In: Oldham KT, Colombani PM, Foglia RP, Skinner MA, editors. Principles and practice of pediatric surgery. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 253–81.

    Google Scholar 

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Correspondence to Hugo A. Heij .

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Heij, H.A. (2020). Lymph Node Disorders. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_92-1

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  • DOI: https://doi.org/10.1007/978-3-642-38482-0_92-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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