1. Cancer chemotherapy as it approaches middle age

   • Stephen K. Carter

   Editorial Pages: 1 - 4

2. New cancer chemotherapy drugs in Europe

   • G. Mathé
   • L. M. van Putten

   Short Review Pages: 5 - 13

3. New drugs under clinical evaluation in the United States

   • Stephen K. Carter

   Short Review Pages: 15 - 24

4. Cardiotoxic effects of antitumor agents

   • Mario Ghione

   Short Review Pages: 25 - 34

5. Sequential combination chemotherapy in advanced breast cancer

   • Cristina Brambilla
   • Pinuccia Valagussa
   • Gianni Bonadonna

   Original Papers Pages: 35 - 39

6. Correlations between experimental chemotherapy in the murine glioma and effectiveness of clinical therapy regimens

   • Victor A. Levin
   • Charles B. Wilson

   Original Papers Pages: 41 - 48

7. In vivo toxicity to lymphoid tissue by 2′-Deoxycoformycin

   • John F. Smyth
   • Robert C. Young
   • David M. Young

   Original Papers Pages: 49 - 51

8. Combined chemotherapy-radiotherapy approach in locally advanced (T_3b-T₄) breast cancer

   • Mario De Lena
   • Roberto Zucali
   • Gianni Bonadonna

   Original Papers Pages: 53 - 59

9. Pharmacokinetic and clinical studies of 24-h infusions of high-dose methotrexate

   • Harvey J. Cohen
   • Norman Jaffe

   Original Papers Pages: 61 - 64