1. 5′-Deoxy-5-fluorouridine improves cachexia by a mechanism independent of its antiproliferative action in colon 26 adenocarcinoma-bearing mice

   • Hiroyuki Eda
   • Yutaka Tanaka
   • Hideo Ishitsuka

   Original Articles Pages: 1 - 6

2. Intracellular uptake and cytotoxic effect in vitro of doxorubicin and epirubicin in human leukemic and normal hematopoietic cells

   • Ulf Tidefelt
   • Britt Sundman-Engberg
   • Christer Paul

   Original Articles Pages: 7 - 12

3. Plasma and cerebrospinal fluid pharmacokinetics of cytosine arabinoside in dogs

   • J. Catharine R. Scott-Moncrieff
   • Thomas C. K. Chan
   • Ralph C. Richardson

   Original Articles Pages: 13 - 18

4. Effect of bismuth nitrate given in combination withcis-diamminedichloroplatinum(II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor

   • Yukihiro Kondo
   • Masahiko Satoh
   • Masao Akimoto

   Original Articles Pages: 19 - 23

5. Chemosensitisation of a drug-sensitive parental cell line by low-dose cyclosporin A

   • Peter R. Twentyman
   • Karen A. Wright

   Original Articles Pages: 24 - 28

6. The relative nephrotoxicity of cisplatin,cis-[Pt(NH₃)₂(guanosine)₂]²⁺, and the hydrolysis product of cisplatin in the rat

   • Mark M. Jones
   • Mark A. Basinger
   • Myron A. Holscher

   Original Articles Pages: 29 - 32

7. Clinical pharmacokinetics of 3-deazaguanine

   • L. Pendyala
   • P. J. Creaven
   • L. R. Whitfield

   Original Articles Pages: 33 - 36

8. Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin α-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069)

   • Michael Binger
   • Paul Workman

   Original Articles Pages: 37 - 47

9. The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells

   • Leonard A. Zwelling
   • Elizabeth Altschuler
   • Diana Chan

   Original Articles Pages: 48 - 52

10. Bayesian estimation of doxorubicin pharmacokinetic parameters

    • F. Bressolle
    • P. Ray
    • J. F. Rossi

    Original Articles Pages: 53 - 60

11. A phase I trial of continuous-infusion cyclophosphamide in refractory cancer patients

    • Joseph P. Eder
    • Anthony D. Elias
    • Karen H. Antman

    Original Articles Pages: 61 - 65

12. Pharmacokinetics of navelbine after oral administration in cancer patients

    • X. J. Zhou
    • P. Boré
    • R. Rahmani

    Original Articles Pages: 66 - 70

13. Carboplatin and vinblastine in advanced non-small-cell lung cancer: a phase II study

    • D. Doll
    • M. Goutsou
    • M. Green

    Original Articles Pages: 71 - 74

14. A pharmacokinetic and pharmacodynamic study of the new anthracycline pirarubicin in breast cancer patients

    • Jacques Robert
    • Alain Monnier
    • Patrice Hérait

    Short Communication Pages: 75 - 79

15. Intensive chemotherapy for adult lymphoblastic lymphomas

    • Raymond Liang
    • David Todd
    • S. L. Loke

    Short Communication Pages: 80 - 82

16. Etoposide, folinic acid, and 5-fluorouracil in carboplatin-pretreated patients with advanced gastric cancer

    • Hansjochen Wilke
    • Peter Preusser
    • Siegfried Seeber

    Short Communication Pages: 83 - 84

17. Positive phase II study in the treatment of advanced malignant melanoma with fotemustine

    • Karin U. Schallreuter
    • Eberhard Wenzel
    • Wolfgang Teichmann

    Short Communication Pages: 85 - 87

18. Meeting announcements

    Announcement Pages: 88 - 88