1. New drug design and development in cancer: present status and future perspectives

   • Paul Workman
   • Dominique Belpomme
   • Jacques Robert

   Editorial Pages: 83 - 84

2. Role of DNA repair in the mechanisms of cell resistance to alkylating agents and cisplatin

   • P. Calsou
   • B. Salles

   Review Pages: 85 - 89

3. Alkylphosphocholines: a new class of membrane-active anticancer agents

   • P. Hilgard
   • T. Klenner
   • C. Unger

   Review Pages: 90 - 95

4. Suramin: an anticancer drug with unique biological effects

   • Annette Kragh Larsen

   Review Pages: 96 - 98

5. Use of pharmacokinetic-pharmacodynamic relationships in the development of new anthracyclines

   • Jacques Robert

   Review Pages: 99 - 102

6. DNA topoisomerase I and II in cancer chemotherapy: update and perspectives

   • Yves Pommier

   Review Pages: 103 - 108

7. Identification of serum components that inhibit the tumoricidal activity of amphiphilic alpha helical peptides

   • Karen A. Peck-Miller
   • Richard P. Darveau
   • H. Perry Fell

   OriginalPaper Pages: 109 - 115

8. Non-glucocorticoid steroid analogues (21-aminosteroids) sensitize multidrug resistant cells to vinblastine

   • Irene Abraham
   • Cindy L. Wolf
   • Kathleen E. Sampson

   OriginalPaper Pages: 116 - 122

9. The antitumor activity of the platinum complex D-17872 is associated with tumor cell differentiation

   • Hans Rainer Maurer
   • Christine Echarti
   • Peter Hilgard

   OriginalPaper Pages: 123 - 128

10. L-asparaginase kills lymphoma cells by apoptosis

    • Michael D. Story
    • David W. Voehringer
    • Raymond E. Meyn

    OriginalPaper Pages: 129 - 133

11. Phase II study of a 72-h concurrent continuous infusion of cisplatin and etoposide in advanced non-small-cell lung cancer

    • Hiroshi Saito
    • Kaoru Shimokata
    • Hidehiko Saito

    OriginalPaper Pages: 134 - 136

12. Gas-chromatographic analysis of busulfan for therapeutic drug monitoring

    • Leanne Embree
    • Robbin B. Burns
    • James H. Goldie

    OriginalPaper Pages: 137 - 142

13. Disposition and metabolism of KW-2149, a novel anticancer agent

    • S. Kobayashi
    • J. Ushiki
    • T. Hirata

    OriginalPaper Pages: 143 - 150

14. Influence of sequential exposure to R-verapamil or B8509-035 on rhodamine 123 accumulation in human lymphoblastoid cell lines

    • Elke Roller
    • Britta Klumpp
    • Kurt Schumacher

    OriginalPaper Pages: 151 - 155

15. The comparative disposition of the pyrolloquinone GR63178A and its 9-hydroxy metabolite GR54374X in sensitive and resistant mouse colon adenocarcinoma

    • Raymond C. French
    • Jeffrey Cummings
    • John F. Smyth

    OriginalPaper Pages: 156 - 161

16. Cisplatin-induced neuropathy in mature rats: Effects of the melanocortin-derived peptide ORG 2766

    • Frank P. T. Hamers
    • Christine Pette
    • Willem-Hendrik Gispen

    OriginalPaper Pages: 162 - 166