1. Marimastat (BB2516): Current status of development

   • William P. Steward

   Article Pages: S56 - S60

2. Involvement of VEGF and its receptors in ascites tumor formation

   • Masabumi Shibuya
   • Jin-Cai Luo
   • Sachiko Yamaguchi

   Article Pages: S72 - S77

3. Antitumor effect of the angiogenesis inhibitor TNP-470 on human digestive organ malignancy

   • Hiroyuki Konno

   Article Pages: S85 - S89

4. Regulatory issues in the evaluation of antimetastatic and other novel anticancer therapies

   • Michael A. Friedman

   Article Pages: S100 - S103

5. Preface

   • Hidehiko Saito
   • Makoto Ogawa
   • Ryuzo Ueda

   Article Pages: S1 - S2

6. Role of radiosurgery in the management of central nervous system metastases

   • Jay S. Loeffler
   • Fred G. Barker
   • Paul H. Chapman

   Article Pages: S11 - S14

7. Heterogeneity of multiorgan metastases of human lung cancer cells genetically engineered to produce cytokines and reversal using chimeric monoclonal antibodies in natural killer cell-depleted severe combined immunodeficient mice

   • Saburo Sone
   • Seiji Yano
   • Tsutomu Shinohara

   Article Pages: S26 - S31

8. SCID-hu mice for the study of human cancer metastasis

   • Reiko Namikawa
   • Emma Shtivelman

   Article Pages: S37 - S41

9. Matrilysin as a target for chemotherapy for colon cancer: use of antisense oligonucleotides as antimetastatic agents

   • Kaoru Miyazaki
   • Naohiko Koshikawa
   • Hiroshi Shimada

   Article Pages: S52 - S55

10. Biological implications of macrophage infiltration in human tumor angiogenesis

    • Mayumi Ono
    • Hitoe Torisu
    • Michihiko Kuwano

    Article Pages: S69 - S71

11. Thalidomide up-regulates prostate-specific antigen secretion from LNCaP cells

    • Shannon C. Dixon
    • Erwin A. Kruger
    • William D. Figg

    Article Pages: S78 - S84

12. Molecular diagnostic detection of free cancer cells in the peritoneal cavity of patients with gastrointestinal and gynecologic malignancies

    • Hayao Nakanishi
    • Yasuhiro Kodera
    • Masae Tatematsu

    Article Pages: S32 - S36

13. Matrix metalloproteinases and metastasis

    • David E. Kleiner
    • William G. Stetler-Stevenson

    Article Pages: S42 - S51

14. Promising new developments in cancer chemotherapy

    • Karen Ferrante
    • Benjamin Winograd
    • Renzo Canetta

    Article Pages: S61 - S68

15. In vivo and ex vivo gene therapy strategies to treat tumors using adenovirus gene transfer vectors

    • Ronald G. Crystal

    Article Pages: S90 - S99

16. Critical determinants of cancer metastasis: rationale for therapy

    • Isaiah J. Fidler

    Article Pages: S3 - S10

17. Successful management of microscopic residual disease in large bowel cancer

    • Paul H. Sugarbaker

    Article Pages: S15 - S25