1. Preface

   • Yutaka Ariyoshi
   • Makoto Ogawa
   • Ryuzo Ueda

   OriginalPaper 18 June 2003 Pages: 1 - 2

2. New approaches to drug discovery and development: a mechanism-based approach to pharmaceutical research and its application to BNP7787, a novel chemoprotective agent

   • Frederick H. Hausheer
   • Harry Kochat
   • Jeffrey D. Saxe

   OriginalPaper 18 June 2003 Pages: 3 - 15

   

3. Structural development of synthetic retinoids and thalidomide-related molecules

   • Yuichi Hashimoto

   OriginalPaper 18 June 2003 Pages: 16 - 23

   

4. Survival-signaling pathway as a promising target for cancer chemotherapy

   • Naoya Fujita
   • Takashi Tsuruo

   OriginalPaper 18 June 2003 Pages: 24 - 28

   

5. Anticancer drug development at the US National Cancer Institute

   • Chris H. Takimoto

   OriginalPaper 18 June 2003 Pages: 29 - 33

   

6. Clinical significance of the expression of estrogen receptors α and β for endocrine therapy of breast cancer

   • Hirotaka Iwase
   • Zhenhan Zhang
   • Shunzo Kobayashi

   OriginalPaper 19 June 2003 Pages: 34 - 38

   

7. New approaches to the endocrine prevention and treatment of breast cancer

   • Anthony Howell
   • Sacha J. Howell
   • D. Gareth Evans

   OriginalPaper 18 June 2003 Pages: 39 - 44

   

8. The opportunities and challenges of personalized genome-based molecular therapies for cancer: targets, technologies, and molecular chaperones

   • Paul Workman

   OriginalPaper 18 June 2003 Pages: 45 - 56

   

9. Pharmacogenomic applications in clinical drug development

   • Nicholas C. Dracopoli

   OriginalPaper 18 June 2003 Pages: 57 - 60

10. Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms

    • Adrian M. Senderowicz

    OriginalPaper 18 June 2003 Pages: 61 - 73

    

11. Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics

    • Takao Yamori

    OriginalPaper 18 June 2003 Pages: 74 - 79

    

12. Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

    • Edward Chu
    • Marc A. Callender
    • John C. Schmitz

    OriginalPaper 18 June 2003 Pages: 80 - 89

    

13. Monoclonal antibodies for the treatment of hematologic malignancies: clinical trials in Japan

    • Kensei Tobinai

    OriginalPaper 18 June 2003 Pages: 90 - 96

    

14. Strategy for the development of novel anticancer drugs

    • Nagahiro Saijo
    • Tomohide Tamura
    • Kazuto Nishio

    OriginalPaper 18 June 2003 Pages: 97 - 101