1. Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective

   • Joseph Ciccolini
   • Cindy Serdjebi
   • Elisa Giovannetti

   Review Article Open access 23 March 2016 Pages: 1 - 12

   

2. Combinational strategies of metformin and chemotherapy in cancers

   • Hui-Hui Zhang
   • Xiu-Li Guo

   Review Article 27 April 2016 Pages: 13 - 26

   

3. Methotrexate-induced toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses

   • Jared M. Campbell
   • Emma Bateman
   • Micah D. J. Peters

   Review Article 03 May 2016 Pages: 27 - 39

   

4. A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib

   • Vikram Malhi
   • Dawn Colburn
   • Richard A. Graham

   Original Article Open access 06 May 2016 Pages: 41 - 49

   

5. Gibberellin derivative GA-13315 sensitizes multidrug-resistant cancer cells by antagonizing ABCB1 while agonizes ABCC1

   • Jiao Mo
   • Min Kang
   • Chen Qing

   Original Article 09 May 2016 Pages: 51 - 61

   

6. Everolimus pharmacokinetics and its exposure–toxicity relationship in patients with thyroid cancer

   • D. de Wit
   • T. C. Schneider
   • N. P. van Erp

   Original Article Open access 11 May 2016 Pages: 63 - 71

   

7. Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors

   • Shivaani Kummar
   • Alice Chen
   • James H. Doroshow

   Original Article 11 May 2016 Pages: 73 - 81

   

8. Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma

   • Oliver E. Bechter
   • Herlinde Dumez
   • Patrick Schöffski

   Original Article 11 May 2016 Pages: 83 - 90

   

9. A prospective, multicenter phase I/II study of induction chemotherapy with docetaxel, cisplatin and fluorouracil (DCF) followed by chemoradiotherapy in patients with unresectable locally advanced esophageal carcinoma

   • Hironaga Satake
   • Makoto Tahara
   • Atsushi Ohtsu

   Original Article Open access 18 May 2016 Pages: 91 - 99

   

10. A phase I study of mTOR inhibitor everolimus in association with cisplatin and radiotherapy for the treatment of locally advanced cervix cancer: PHOENIX I

    • Andréia Cristina de Melo
    • Rachele Grazziotin-Reisner
    • Carlos Gil Ferreira

    Original Article 20 May 2016 Pages: 101 - 109

    

11. Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation

    • Takaya Yamashita
    • Naohito Fujishima
    • Naoto Takahashi

    Original Article Open access 23 May 2016 Pages: 111 - 118

    

12. UGT1A1 gene polymorphism is associated with toxicity and clinical efficacy of irinotecan-based chemotherapy in patients with advanced colorectal cancer

    • Chunlei Xu
    • Xushan Tang
    • Yong Tang

    Original Article 24 May 2016 Pages: 119 - 130

    

13. Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals

    • Emma C. Martin
    • Leon Aarons
    • James W. T. Yates

    Original Article Open access 25 May 2016 Pages: 131 - 141

    

14. Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study

    • Kezban Nur Pilancı
    • Sezer Saglam
    • Esra Kaytan-Saglam

    Original Article 06 June 2016 Pages: 143 - 150

    

15. Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency

    • Muhammad Wasif Saif
    • Robert B. Diasio

    Original Article 08 June 2016 Pages: 151 - 156

16. Pharmacokinetics and safety of vitamin E δ-tocotrienol after single and multiple doses in healthy subjects with measurement of vitamin E metabolites

    • Amit Mahipal
    • Jason Klapman
    • Mokenge P. Malafa

    Original Article 08 June 2016 Pages: 157 - 165

    

17. Association between new-onset hypothyroidism and clinical response in patients treated with tyrosine kinase inhibitor therapy in phase I clinical trials

    • Mehmet Asim Bilen
    • Amy Patel
    • Aung Naing

    Original Article 10 June 2016 Pages: 167 - 171

18. Pharmacokinetics, safety, and efficacy of lenalidomide plus dexamethasone in patients with multiple myeloma and renal impairment

    • Frank Bridoux
    • Nianhang Chen
    • Jean Paul Fermand

    Original Article 10 June 2016 Pages: 173 - 182

    

19. Effect of renal function on pemetrexed-induced haematotoxicity

    • Yosuke Ando
    • Takahiro Hayashi
    • Shigeki Yamada

    Original Article Open access 10 June 2016 Pages: 183 - 189

20. RETRACTED ARTICLE: Atrial natriuretic peptide protects against cisplatin-induced granulocytopenia

    • Takashi Nojiri
    • Hiroshi Hosoda
    • Kenji Kangawa

    Original Article 10 June 2016 Pages: 191 - 197

    

21. Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia–lymphoma and peripheral T-cell lymphoma

    • Michinori Ogura
    • Takashi Ishida
    • Atae Utsunomiya

    Original Article Open access 11 June 2016 Pages: 199 - 207

    

22. Monte Carlo simulations of the clinical benefits from therapeutic drug monitoring of sunitinib in patients with gastrointestinal stromal tumours

    • Sebastiaan C. Goulooze
    • Peter Galettis
    • Jennifer H. Martin

    Original Article 13 June 2016 Pages: 209 - 216

    

23. Developing more effective, non-neurotoxic, methotrexate-based therapy in infants with brain tumors

    • Ian J. Cohen

    Letter to the Editor 23 May 2016 Pages: 217 - 218

24. Reply to Prof Ian J. Cohen

    • Maurizio Lucchesi
    • Iacopo Sardi

    Letter to the Editor 23 May 2016 Pages: 219 - 220