Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever H. R. WardillC. E. M. de MooijN. M. A. Blijlevens Original Article Open access 20 April 2021 Pages: 173 - 188
Population pharmacokinetics and exposure–response of selumetinib and its N‐desmethyl metabolite in pediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas Stein SchalkwijkLi ZhouDiansong Zhou Original Article 26 April 2021 Pages: 189 - 202
Tissue distribution of epirubicin after severe extravasation in humans Jakob NedomanskyWerner HaslikRobert M. Mader Original Article Open access 27 April 2021 Pages: 203 - 209
Time-dependent population PK models of single-agent atezolizumab in patients with cancer Mathilde MarchandRong ZhangRené Bruno Original Article 27 April 2021 Pages: 211 - 221
Downregulation of SELENBP1 enhances oral squamous cell carcinoma chemoresistance through KEAP1–NRF2 signaling Hui ZengXubing ZhaoChengfang Tang Original Article 27 April 2021 Pages: 223 - 233
Glaucocalyxin A induces apoptosis and autophagy in tongue squamous cell carcinoma cells by regulating ROS Fanzhe ShiDanfeng XueJiaxuan Qiu Original Article 27 April 2021 Pages: 235 - 246
Population pharmacokinetic model of irinotecan and its four main metabolites in patients treated with FOLFIRI or FOLFIRINOX regimen Laure DeymeDominique BarbolosiFlorence Gattacceca Original Article 28 April 2021 Pages: 247 - 258
Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment Nikolay GrechkoViera SkarbovaJim Xiao Original Article Open access 28 April 2021 Pages: 259 - 270
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study Stine Nygaard NielsenLinea Natalie ToksvangKjeld Schmiegelow Original Article 29 April 2021 Pages: 271 - 279
Exploratory analysis of target concentration of lenvatinib in the treatment of hepatocellular carcinoma Satoshi NodaHiroya IidaTomohiro Terada Original Article 29 April 2021 Pages: 281 - 288
NCTR25 fusion facilitates the formation of TRAIL polymers that selectively activate TRAIL receptors with higher potency and efficacy than TRAIL Yan WangQiong LeiNan Wang Original Article 04 May 2021 Pages: 289 - 306
An exploration of the impact of ethanol diluent on breath alcohol concentration in patients receiving paclitaxel chemotherapy R. J. KeoghM. MilewskiO. S. Breathnach Original Article 04 May 2021 Pages: 307 - 312
Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia Yomna H. YoussefSara M. MakkeyahNefissa H. Meky Original Article 07 May 2021 Pages: 313 - 321
Autophagy inhibitor potentiates the antitumor efficacy of apatinib in uterine sarcoma by stimulating PI3K/Akt/mTOR pathway Shucheng ChenLan Yao Original Article 12 May 2021 Pages: 323 - 334
Phase 1 study of alisertib (MLN8237) and weekly irinotecan in adults with advanced solid tumors Thomas J. SemradEdward J. KimKaren Kelly Original Article 15 May 2021 Pages: 335 - 341
MiRNA-3662 reverses the gemcitabine resistance in pancreatic cancer through regulating the tumor metabolism An LiuYonggui ZhouJia Xu Original Article 15 May 2021 Pages: 343 - 357
Toxicity and pharmacokinetics of actinomycin-D and vincristine in children and adolescents: Children’s Oncology Group Study ADVL06B1 Jeffrey SkolnikDavid HallJoel M. Reid Short Communication 22 May 2021 Pages: 359 - 365
Correction to: Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-α and translocating PKC-δ Xian-Ming ZhangJia ChenQiang Xu Correction 28 April 2021 Pages: 367 - 368
