Abstract
Nanopolymers are one of the most important nanomaterials for the future. Nanopolymers are declared as particle dispersions or solid particles with size at the nanoscale. Nanopolymers have come into prominence due to the fact that they give some opportunities such as building nanoscale parts, self-assembly structures at controllable and variable scales, the downscaling of size, and new phase transitions. Nanopolymers can enhance high efficiency and selectivity to active compounds. Nanopolymers are constructed from biocompatible and biodegradable polymers which are one of the new trends of biomaterial where the drug is dissolved, entrapped, encapsulated, or attached to a nanoparticle matrix. They can be used as green chemistry in different applications for medicine, engineering, and pharmacy.
Electrochemical methods have many advantages such as less time-consuming analysis, the usage of mini-portable and of affordable analyzer, and determination of sample without interferences. These methods give much information about the electrochemical behavior of a drug. Therefore, it can be sorted out to understand its in vivo redox reaction and pharmacological activity. The interest in developing electrochemical sensor systems is sharply increasing at clinical assays and in environmental monitoring.
Biodegradable nanopolymers are promising carriers for many active compounds and are gaining importance over application of traditional oral and intravenous methods in regard to efficiency and selectivity. When biocompatible materials are applied to the body, it is expected to perform a desired response without any side effects. In this chapter, commonly used biocompatible polymers in drug delivery as nanoparticles were described. Also, we described the recent electrochemical applications of biocompatible and biodegradable nanopolymeric materials for pharmaceutical assays.
References
Adak T, Kumar J, Shakil NA, Walia S (2012) Development of controlled release formulations of imidacloprid employing novel nano-ranged amphiphilic polymers. J Environ Sci Health B 47:217–225. https://doi.org/10.1080/03601234.2012.634365
Aftim N, Istamboulié G, Piletska E et al (2017) Biosensor-assisted selection of optimal parameters for designing molecularly imprinted polymers selective to phosmet insecticide. Talanta 174:414–419. https://doi.org/10.1016/j.talanta.2017.06.035
Alexis F, Pridgen E, Molnar LK, Farokhzad OC (2008) Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 5:505–515. https://doi.org/10.1021/mp800051m
Ashrafi H, Hasanzadeh M, Ansarin K et al (2018) Application of chitosan as biocompatible polysaccharide in quantification of some benzodiazepines affecting sleep disorders: a new platform for preparation of bioactive scaffolds. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2018.09.017
Beck F, Braun P, Schloten F (1989) Anodic release of anions from polypyrrole. J Electroanal Chem Interfacial Electrochem 267:141–148. https://doi.org/10.1016/0022-0728(89)80244-X
Bose S, Vahabzadeh S, Bandyopadhyay A (2013) Bone tissue engineering using 3D printing. Mater Today 16:496–504. https://doi.org/10.1016/J.MATTOD.2013.11.017
Brannon-Peppas L, Blanchette JO (2004) Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 56:1649–1659. https://doi.org/10.1016/j.addr.2004.02.014
Calvo P, Gouritin B, Chacun H et al (2001) Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery. Pharm Res 18:1157–1166. https://doi.org/10.1023/A:1010931127745
Campos VF, Komninou ER, Urtiaga G et al (2011) NanoSMGT: transfection of exogenous DNA on sex-sorted bovine sperm using nanopolymer. Theriogenology 75:1476–1481. https://doi.org/10.1016/j.theriogenology.2011.01.009
Christensen PA, Hamnett A (1991) In situ spectroscopic investigations of the growth, electrochemical cycling and overoxidation of polypyrrole in aqueous solution. Electrochim Acta 36:1263–1286. https://doi.org/10.1016/0013-4686(91)80005-S
De Jong WH, Borm PJA (2008) Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine 3:133–149
Demirer GS, Okur AC, Kizilel S (2015) Synthesis and design of biologically inspired biocompatible iron oxide nanoparticles for biomedical applications. J Mater Chem B 3:7831–7849. https://doi.org/10.1039/C5TB00931F
Ensafi AA, Khoddami E, Nabiyan A, Rezaei B (2017) Study the role of poly(diethyl aminoethyl methacrylate) as a modified and grafted shell for TiO2 and ZnO nanoparticles, application in flutamide delivery. React Funct Polym. https://doi.org/10.1016/j.reactfunctpolym.2017.04.016
Esim O, Savaser A, Kurbanoglu S et al (2017) Development of assay for determination of eletriptan hydrobromide in loaded PLGA nanoparticles. J Pharm Biomed Anal 142:74–83. https://doi.org/10.1016/j.jpba.2017.05.002
Farah S, Anderson DG (2016) Physical and mechanical properties of PLA, and their functions in widespread applications – a comprehensive review. Adv Drug Deliv Rev 107:367–392. https://doi.org/10.1016/J.ADDR.2016.06.012
Feng S-S (2004) Nanoparticles of biodegradable polymers for new-concept chemotherapy. Expert Rev Med Devices 1:115–125. https://doi.org/10.1586/17434440.1.1.115
Feng Q, Han Y, Yu M et al (2017) A robust and soluble nanopolymer based on molecular grid-based nanomonomer. Chin J Polym Sci 35:87–97. https://doi.org/10.1007/s10118-016-1856-7
Ferain E et al. (2009) Drug-eluting nanowire array (WO/2009/050168)
Gao Y, Xie J, Chen H et al (2014) Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnol Adv 32:761–777. https://doi.org/10.1016/J.BIOTECHADV.2013.10.013
Garcia-Garcia E, Gil S, Andrieux K et al (2005) A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles. Cell Mol Life Sci 62:1400–1408. https://doi.org/10.1007/s00018-005-5094-3
Ghodsi J and Rafati AA (2018) Research paper A novel molecularly imprinted sensor for imidacloprid pesticide based on poly(levodopa) electro-polymerized/TiO2 nanoparticles composite. Anal Bioanal Chem 410:7621–7633
Hardy JG, Mouser DJ, Arroyo-Currás N et al (2014) Biodegradable electroactive polymers for electrochemically-triggered drug delivery. J Mater Chem B 2:6809–6822. https://doi.org/10.1039/C4TB00355A
Hasanzadeh M, Razmi N, Mokhtarzadeh A et al (2018a) Aptamer based assay of plated-derived grow factor in unprocessed human plasma sample and MCF-7 breast cancer cell lysates using gold nanoparticle supported α-cyclodextrin. Int J Biol Macromol 108:69–80. https://doi.org/10.1016/J.IJBIOMAC.2017.11.149
Hasanzadeh M, Babaie P, Jouyban-Gharamaleki V, Jouyban A (2018b) The use of chitosan as a bioactive polysaccharide in non-invasive detection of malondialdehyde biomarker in human exhaled breath condensate: a new platform towards diagnosis of some lung disease. Int J Biol Macromol. https://doi.org/10.1016/j.ijbiomac.2018.09.018
Janaki V et. al.(2015) Polypyrrole-A conducting nanopolymer for the treatment of simulated textile effluent. J Environ Biotechnol Res 1:45–51
Jetzschmann KJ, Jágerszki G, Dechtrirat D et al (2015) Vectorially imprinted hybrid nanofilm for acetylcholinesterase recognition. Adv Funct Mater 25:5178–5183. https://doi.org/10.1002/adfm.201501900
Karadas-Bakirhan N, Patris S, Ozkan SA et al (2016) Determination of the anticancer drug sorafenib in serum by adsorptive stripping differential pulse voltammetry using a chitosan/multiwall carbon nanotube modified glassy carbon electrode. Electroanalysis 28:358–365. https://doi.org/10.1002/elan.201500384
Karimzadeh I, Aghazadeh M, Dalvand A et al (2017) Effective electrosynthesis and in situ surface coating of Fe3O4 nanoparticles with polyvinyl alcohol for biomedical applications. Mater Res Innov 8917:1–8. https://doi.org/10.1080/14328917.2017.1343968
Karunaratne DN (2007) Nanotechnology in medicine. J Natl Sci Found 35:149. https://doi.org/10.4038/jnsfsr.v35i3.2012
Kataoka K, Harada A, Nagasaki Y (2001) Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev 47:113–131. https://doi.org/10.1016/S0169-409X(00)00124-1
Kayser O, Lemke A, Hernández-Trejo N (2005) The impact of nanobiotechnology on the development of new drug delivery systems. Curr Pharm Biotechnol 6:3–5
Khan MA, Mujahid M, Gul IH, Hussain A (2018) Electrochemical study of magnetic nanogel designed for controlled release of chlorhexidine gluconate. Electrochim Acta. https://doi.org/10.1016/j.electacta.2018.10.098
Khan MA, Mujahid M, Gul IH, Hussain A (2019) Electrochemical study of magnetic nanogel designed for controlled release of chlorhexidine gluconate. Electrochim Acta 295:113–123. https://doi.org/10.1016/J.ELECTACTA.2018.10.098
Kocak G, Tuncer C, Bütün V (2017) pH-responsive polymers. Polym Chem 8:144–176. https://doi.org/10.1039/C6PY01872F
Kor K, Zarei K (2016) Development and characterization of an electrochemical sensor for furosemide detection based on electropolymerized molecularly imprinted polymer. Talanta 146:181–187. https://doi.org/10.1016/j.talanta.2015.08.042
Kumari A, Yadav SK, Yadav SC (2010) Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces 75:1–18. https://doi.org/10.1016/j.colsurfb.2009.09.001
Lange U, Roznyatovskaya NV, Mirsky VM (2008) Conducting polymers in chemical sensors and arrays. Anal Chim Acta 614:1–26. https://doi.org/10.1016/j.aca.2008.02.068
Lee KM et. al. (2018) Chemical design of functional polymer structures for biosensors: from nanoscale to macroscale. Polymers 10:551
Leprince L, Dogimont A, Magnin D, Demoustier-Champagne S (2010) Dexamethasone electrically controlled release from polypyrrole-coated nanostructured electrodes. J Mater Sci Mater Med 21:925
Liu S, Gordiichuk P, Wu Z-S et al (2015) Patterning two-dimensional free-standing surfaces with mesoporous conducting polymers. Nat Commun 6:8817. https://doi.org/10.1038/ncomms9817
Liu S, Zhang J, Dong R et al (2016) Two-dimensional mesoscale-ordered conducting polymers. Angew Chem Int Ed 55:12516–12521. https://doi.org/10.1002/anie.201606988
Liu Y, Wei M, Hu Y et al (2018) An electrochemical sensor based on a molecularly imprinted polymer for determination of anticancer drug Mitoxantrone. Sens Actuators B Chem 255:544–551. https://doi.org/10.1016/J.SNB.2017.08.023
Ljubimova JY, Holler E (2012) Biocompatible nanopolymers: the next generation of breast cancer treatment? Nanomedicine 7:1467–1470. https://doi.org/10.2217/nnm.12.115
Łukasiewicz S, Szczepanowicz K, Błasiak E, Dziedzicka-Wasylewska M (2015) Biocompatible polymeric nanoparticles as promising candidates for drug delivery. Langmuir 31:6415–6425. https://doi.org/10.1021/acs.langmuir.5b01226
Ma Y, Shen X-L, Zeng Q, Wang L-S (2017a) A glassy carbon electrode modified with graphene nanoplatelets, gold nanoparticles and chitosan, and coated with a molecularly imprinted polymer for highly sensitive determination of prostate specific antigen. Microchim Acta 4469–4476. https://doi.org/10.1007/s00604-017-2458-y
Ma Y, Shen XL, Wang HS et al (2017b) MIPs-graphene nanoplatelets-MWCNTs modified glassy carbon electrode for the determination of cardiac troponin I. Anal Biochem 520:9–15. https://doi.org/10.1016/j.ab.2016.12.018
Ma Y, Shen XL, Zeng Q et al (2017c) A multi-walled carbon nanotubes based molecularly imprinted polymers electrochemical sensor for the sensitive determination of HIV-p24. Talanta 164:121–127. https://doi.org/10.1016/j.talanta.2016.11.043
Maeda H, Wu J, Sawa T et al (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 65:271–284
Mohd Yussof SJ, Halim AS, Mat Saad AZ, Jaafar H (2011) Evaluation of the biocompatibility of a bilayer chitosan skin regenerating template, human skin allograft, and integra implants in rats. ISRN Mater Sci 2011:1–7. https://doi.org/10.5402/2011/857483
Mokhtarzadeh A, Alibakhshi A, Yaghoobi H et al (2016a) Recent advances on biocompatible and biodegradable nanoparticles as gene carriers. Expert Opin Biol Ther 16:771–785. https://doi.org/10.1517/14712598.2016.1169269
Mokhtarzadeh A, Alibakhshi A, Hejazi M et al (2016b) Bacterial-derived biopolymers: advanced natural nanomaterials for drug delivery and tissue engineering. TrAC Trends Anal Chem 82:367–384. https://doi.org/10.1016/J.TRAC.2016.06.013
Mokhtarzadeh A, Alibakhshi A, Hashemi M et al (2017) Biodegradable nano-polymers as delivery vehicles for therapeutic small non-coding ribonucleic acids. J Control Release 245:116–126. https://doi.org/10.1016/j.jconrel.2016.11.017
Moraru AD, Costuleanu M, Sava A et al (2014) Intraocular biodistribution of intravitreal injected chitosan/gelatin nanoparticles. Rom J Morphol Embryol 55:869–875
Murdan S (2003) Electro-responsive drug delivery from hydrogels. J Control Release 92:1–17. https://doi.org/10.1016/S0168-3659(03)00303-1
Mygind ND, Harutyunyan MJ, Mathiasen AB et al (2011) The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease. Inflamm Res 60:281–287. https://doi.org/10.1007/s00011-010-0266-5
Nagavarma BVN, Yadav HKS, Ayaz A et al (2012) Different techniques for preparation of polymeric nanoparticles- a review. Asian J Pharm Clin Res 5:16–23. https://doi.org/10.1186/s13104-016-1898-5
Naguib HF, Abdel Aziz MS, Sherif SM, Saad GR (2011) Synthesis and thermal characterization of poly(ester-ether urethane)s based on PHB and PCL-PEG-PCL blocks. J Polym Res 18:1217–1227. https://doi.org/10.1007/s10965-010-9525-y
Najafi E, Aboufazeli F, Lotfi Zadeh Zhad HR et al (2013) A novel magnetic ion imprinted nano-polymer for selective separation and determination of low levels of mercury(II) ions in fish samples. Food Chem 141:4040–4045. https://doi.org/10.1016/J.FOODCHEM.2013.06.118
Naseri M, Akbarzadeh A, Spotin A et al (2016) Scolicidal and apoptotic activities of albendazole sulfoxide and albendazole sulfoxide-loaded PLGA-PEG as a novel nanopolymeric particle against Echinococcus granulosus protoscoleces. Parasitol Res 115:4595–4603. https://doi.org/10.1007/s00436-016-5250-8
Pacheco JG, Rebelo P, Cagide F et al (2019) Electrochemical sensing of the thyroid hormone thyronamine (T0AM) via molecular imprinted polymers (MIPs). Talanta 194:689–696. https://doi.org/10.1016/j.talanta.2018.10.090
Pardoe H, Chua-anusorn W, St. Pierre TG, Dobson J (2001) Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol. J Magn Magn Mater 225:41–46. https://doi.org/10.1016/S0304-8853(00)01226-9
Pardridge WM (1999) Vector-mediated drug delivery to the brain. Adv Drug Deliv Rev 36:299–321
Peer D, Karp JM, Hong S et al (2007) Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2:751–760. https://doi.org/10.1038/nnano.2007.387
Rani S, Gothwal A, Khan I et al (2018) Smartly engineered PEGylated di-block nanopolymeric micelles: duo delivery of isoniazid and rifampicin against Mycobacterium tuberculosis. AAPS PharmSciTech 19:3237–3248. https://doi.org/10.1208/s12249-018-1151-8
Sahoo SK, Parveen S, Panda JJ (2007) The present and future of nanotechnology in human health care. Nanomedicine 3:20–31. https://doi.org/10.1016/J.NANO.2006.11.008
Schroeder U, Sommerfeld P, Ulrich S, Sabel BA (1998) Nanoparticle technology for delivery of drugs across the blood–brain barrier. J Pharm Sci 87:1305–1307. https://doi.org/10.1021/js980084y
Shenoy DB, Amiji MM (2005) Poly(ethylene oxide)-modified poly(ɛ-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer. Int J Pharm 293:261–270. https://doi.org/10.1016/j.ijpharm.2004.12.010
Shi Z, Gao X, Ullah MW et al (2016) Electroconductive natural polymer-based hydrogels. Biomaterials 111:40–54. https://doi.org/10.1016/j.biomaterials.2016.09.020
Sirivisoot S, Pareta RA, Webster TJ (2011a) A conductive nanostructured polymer electrodeposited on titanium as a controllable, local drug delivery platform. J Biomed Mater Res A 99A: 586–597. https://doi.org/10.1002/jbm.a.33210
Sirivisoot S, Pareta R, Webster TJ (2011b) Electrically controlled drug release from nanostructured polypyrrole coated on titanium. Nanotechnology. https://doi.org/10.1088/0957-4484/22/8/085101
Vaisocherová H, Zhang Z, Yang W et al (2009) Functionalizable surface platform with reduced nonspecific protein adsorption from full blood plasma-material selection and protein immobilization optimization. Biosens Bioelectron 24:1924–1930. https://doi.org/10.1016/j.bios.2008.09.035
Vasir JK, Labhasetwar V (2005) Targeted drug delivery in cancer therapy. Technol Cancer Res Treat 4:363–374. https://doi.org/10.1177/153303460500400405
Vasir J, Reddy M, Labhasetwar V (2005) Nanosystems in drug targeting: opportunities and challenges. Curr Nanosci 1:47–64. https://doi.org/10.2174/1573413052953110
Vorhies JS, Nemunaitis JJ (2009) Synthetic vs. natural/biodegradable polymers for delivery of shRNA-based cancer therapies. Methods Mol Biol 480:11–29
Wang J, Hui N (2019) Zwitterionic poly(carboxybetaine) functionalized conducting polymer polyaniline nanowires for the electrochemical detection of carcinoembryonic antigen in undiluted blood serum. Bioelectrochemistry 125:90–96. https://doi.org/10.1016/j.bioelechem.2018.09.006
Wang Q, Huang JY, Li HQ et al (2017a) Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications. Int J Nanomedicine 12:151
Wang Y, Han M, Ye X et al (2017b) Voltammetric myoglobin sensor based on a glassy carbon electrode modified with a composite film consisting of carbon nanotubes and a molecularly imprinted polymerized ionic liquid. Microchim Acta 184:195–202. https://doi.org/10.1007/s00604-016-2005-2
Wang T, Fang Y, He Z (2017c) Electrochemical quantitative detection of glial fibrillary acidic protein based on molecularly imprinted polymer sensor. Int J Electrochem Sci 12:7341–7350. https://doi.org/10.20964/2017.08.69
Xia X, Xia X, Huo W et al (2016) Toxic effects of imidacloprid on adult loach (Misgurnus anguillicaudatus). Environ Toxicol Pharmacol 45:132–139. https://doi.org/10.1016/j.etap.2016.05.030
Xin H, Jiang X, Gu J et al (2011) Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. Biomaterials 32:4293–4305. https://doi.org/10.1016/j.biomaterials.2011.02.044
Yadavalli T, Ramasamy S, Chandrasekaran G et al (2015) Dual responsive PNIPAM–chitosan targeted magnetic nanopolymers for targeted drug delivery. J Magn Magn Mater 380:315–320. https://doi.org/10.1016/J.JMMM.2014.09.035
Yarman A, Scheller FW (2014) The first electrochemical MIP sensor for tamoxifen. Sensors (Basel) 14:7647–7654. https://doi.org/10.3390/s140507647
Zambaux MF, Bonneaux F, Gref R et al (1999) Preparation and characterization of protein C-loaded PLA nanoparticles. J Control Release 60:179–188. https://doi.org/10.1016/S0168-3659(99)00073-5
Zhang Z, Chen S, Chang Y, Jiang S (2006) Surface grafted sulfobetaine polymers via atom transfer radical polymerization as superlow fouling coatings. J Phys Chem B 110:10799–10804. https://doi.org/10.1021/jp057266i
Zheng Q, Niu Y, Li H (2016) Synthesis and characterization of imidacloprid microspheres for controlled drug release study. React Funct Polym 106:99–104. https://doi.org/10.1016/j.reactfunctpolym.2016.07.006
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this entry
Cite this entry
Ozcelikay, G., Esim, O., Bakirhan, N.K., Savaser, A., Ozkan, Y., Ozkan, S.A. (2019). Biocompatible Nanopolymers in Drug Delivery Systems and Their Recent Electrochemical Applications in Drug Assays. In: Hussain, C., Thomas, S. (eds) Handbook of Polymer and Ceramic Nanotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-10614-0_24-1
Download citation
DOI: https://doi.org/10.1007/978-3-030-10614-0_24-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-10614-0
Online ISBN: 978-3-030-10614-0
eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics