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Adenocarcinoma, Lung

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Lepidic predominant adenocarcinoma; Acinar predominant adenocarcinoma; Papillary predominant adenocarcinoma; Solid predominant adenocarcinoma; Micropapillary predominant adenocarcinoma

Definition

Invasive adenocarcinoma is a malignant epithelial tumor showing glandular differentiation, mucin production, or “pneumocyte marker” expression determined by immunohistochemistry (IHC). Patterns of glandular differentiation which are associated with adenocarcinoma subtypes are lepidic, acinar, papillary, micropapillary, and solid.

Clinical Features

Incidence and Etiology

Lung cancer in general is the commonest cause of lung cancer globally, and adenocarcinoma is the most common form of lung cancer in global terms. In the USA, the lung cancer incidence rate is approximately 35 cases per 100,000 person-years, but such figures are of questionable value given the considerable variations, largely due to regional variance in tobacco consumption. In several European countries, this figure can...

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References and Further Reading

  • Devarakona, S., Morgensztern, D., & Govindan, R. (2015). Genomic alterations in lung adenocarcinoma. Lancet Oncology, 16, e342–e351.

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  • Greulich, H. (2011). The genomics of lung adenocarcinoma: Opportunities for targeted therapies. Genes & Cancer, 1, 1200–1210.

    Article  Google Scholar 

  • Imielinski, M., Berger, A. H., Hammerman, P., et al. (2012). Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell, 150, 1107–1120.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kerr, K. M. (2009). Pulmonary adenocarcinoma: Classification and reporting. Histopathology, 54, 12–27.

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  • Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.

    Article  PubMed  PubMed Central  Google Scholar 

  • Travis, W. D., Brambilla, E., Noguchi, M., et al. (2013). Diagnosis of lung cancer in small biopsies and cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Archives of Pathology & Laboratory Medicine, 137, 668–684.

    Article  Google Scholar 

  • Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO press.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Aberdeen, UK

    Keith M Kerr

  2. Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, UK

    Gavin M Laing

Authors
  1. Keith M Kerr
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  2. Gavin M Laing
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Corresponding author

Correspondence to Keith M Kerr .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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© 2017 Springer International Publishing AG

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Kerr, K.M., Laing, G.M. (2017). Adenocarcinoma, Lung. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4336-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4336-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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