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Adenomyoepithelioma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Definition

Adenomyoepithelioma (AME) is a benign tumor of the breast, composed by a biphasic proliferation of phenotypically distinct myoepithelial cells and luminal epithelial cells.

Following the first description by Hamperl (1970), Tavassoli (1991) identified three histologic variants, in which myoepithelial and epithelial cells are present in variable percentages, namely, spindle, tubular, and lobulated AME (Tavassoli 1991).

AME with malignant features have seldom been reported (Hayes 2011) and named AME with carcinoma, when epithelial cells or myoepithelial cells show malignant cytomorphological features and malignant AME when these are present in both components (Brogi 2014).

Clinical Features

  • Incidence

    • AME is an extremely rare tumor, a few small case series and single case reports having been reported so far. (Decorsiere et al. 1988; McLaren et al. 2005; Loose et al. 1992; Rosen 1987; Tavassoli 1991). AME with carcinoma and malignant AME are even more infrequent than their...

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References and Further Reading

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Authors and Affiliations

  1. Department of Emergency and Organ Transplantation, Università degli Studi di Bari Aldo Moro – Policlinico, Bari, Italy

    Eugenio Maiorano, Enrica Macorano & Mauro Giuseppe Mastropasqua

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  1. Eugenio Maiorano
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  2. Enrica Macorano
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  3. Mauro Giuseppe Mastropasqua
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Correspondence to Eugenio Maiorano .

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Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Maiorano, E., Macorano, E., Mastropasqua, M.G. (2018). Adenomyoepithelioma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4698-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4698-1

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