Definition
Primary tumor with pure glandular phenotype which originates de novo within the urothelium.
Among the tumors with glandular feature originating in the urinary tract, the following histologic subtypes are recognized: adenocarcinoma not otherwise specified (NOS), enteric, mucinous, signet ring cell, hepatoid, and mixed; tumors of Mullerian type (clear cell and endometrioid adenocarcinomas); and urachal adenocarcinoma. The Mullerian-type neoplasms and urachal adenocarcinoma are characterized by different epidemiologies and natural histories, and they have been discussed separately in the chapters Mullerian-type tumors and urachal carcinoma.
References and Further Reading
Alanee, S., Alvarado-Cabrero, I., Murugan, P., et al. (2019). Update of the International Consultation on Urological Diseases on bladder cancer 2018: Non-urothelial cancers of the urinary bladder. World Journal of Urology, 37, 107–114.
Gordetsky, J., & Epstein, J. I. (2015). Intestinal metaplasia of the bladder with dysplasia: A risk factor for carcinoma? Histopathology, 67, 325–330.
Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of tumours of the urinary system and male genital organs (pp. 99–107). Lyon: IARC.
Rao, Q., Williamson, S. R., Lopez-Beltran, A., et al. (2013). Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: Extended immunohistochemical profiles emphasizing novel markers. Modern Pathology, 26, 725–732.
Xin, Z., Zhao, C., Huang, T., et al. (2016). Intestinal metaplasia of the bladder in 89 patients: A study with emphasis on long-term outcome. BMC Urology, 16, 24.
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Raspollini, M.R., Cimadamore, A., Montironi, R., Lopez-Beltran, A. (2020). Urinary Tract Adenocarcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4971-1
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