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Urinary Tract Large Cell Neuroendocrine Carcinoma

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Large cell type; Undifferentiated neuroendocrine carcinoma

Definition

Urinary tract large cell neuroendocrine carcinoma (LCNEC) is a high-grade carcinoma with large cells showing neuroendocrine differentiation.

Clinical Features

  • Incidence

    LCNEC is a rare tumor. To date, approximately 20 cases of bladder LCNEC of pure and mixed histology have been reported in the literature (Oshiro et al. 2013; Radović et al. 2015), even with small cell neuroendocrine carcinoma.

  • Age

    The tumor occurs mostly in men.

  • Sex

    The age of diagnosis ranges from 61 to 87 years (mean 74 years) (Moch et al. 2016).

  • Site

    LCNEC is mainly reported in the bladder, and single cases have been described in upper urinary tract (Oshiro et al. 2013).

  • Treatment

    Treatment strategies for LCNEC are represented by cystectomy and chemotherapy.

  • Outcome

    Most patients with LCNEC present with high-stage disease and have a poor prognosis. To date, the only reported series of LCNEC of the bladder compared to small cell...

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References and Further Reading

  • Evans, A. E., Al-Maghrabi, J., Tsihlias, J., et al. (2002). Primary large cell neuroendocrine carcinoma of the urinary bladder. Archives of Pathology & Laboratory Medicine, 126, 1229–1232.

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  • Hailemariam, S., Gaspert, A., Komminoth, P., et al. (1998). Primary, pure, largecell neuroendocrine carcinoma of the urinary bladder. Modern Pathology, 11, 1016–11020.

    CAS  PubMed  Google Scholar 

  • Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. (2016). Who classification of Tumours of the urinary system and male genital organs. Lyon: IARC Press.

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  • Oshiro, H., Odagaki, Y., Iobe, H., et al. (2013). Primary large cell neuroendocrine carcinoma of the ureter. International Journal of Clinical and Experimental Pathology, 6, 729–736.

    PubMed  PubMed Central  Google Scholar 

  • Radović, N., Turner, R., & Baralja, F. (2015). Primary “pure” large cell neuroendocrine carcinoma of the urinary bladder: A case report and review of the literature. Clinical Genitourinary Cancer, 13, e375–e377.

    Article  Google Scholar 

  • Vollbrecht, C., Werner, R., Walter, R. F., et al. (2015). Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: A comparison of a neglected tumour group. British Journal of Cancer, 113, 1704–1711.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  3. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  4. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Maria Rosaria Raspollini
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  2. Alessia Cimadamore
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  3. Rodolfo Montironi
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  4. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Raspollini, M.R., Cimadamore, A., Montironi, R., Lopez-Beltran, A. (2020). Urinary Tract Large Cell Neuroendocrine Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4972-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4972-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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