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Urinary Tract Well-Differentiated Neuroendocrine Tumor

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Carcinoid tumor

Definition

Well differentiated neuroendocrine carcinoma (WDNET) of the urinary tract is recognized as a distinct entity of neuroendocrine neoplasm arising from isolated neuroendocrine cells in the basal layer of the urothelium.

Clinical Features

  • Incidence

    WDNET is a very rare neoplasm, few cases of pure tumors have been described. Other reports have described “carcinoid tumors” with coexisting carcinomatous component such as adenocarcinoma or small cell carcinoma (Martignoni and Eble 2003).

  • Age

    The tumor occurs predominantly in elderly patients (range, 30–75 years of age) (Chen and Epstein 2011).

  • Sex

    It has reported a slight male predominance.

  • Site

    It has a predilection for the submucosa of trigone, bladder neck, and prostatic urethra (Chen and Epstein 2011).

  • Treatment

    The treatment for localized disease is similar to the treatment of carcinoids in other organs and primarily involves surgical resection with clinical follow-up (Tassar 2011).

  • Outcome...

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References and Further Reading

  • Chen, Y. B., & Epstein, J. I. (2011). Primary carcinoid tumors of the urinary bladder and prostatic urethra: Clinicopathologic study of 6 cases. The American Journal of Surgical Pathology, 35, 442–446.

    CAS  PubMed  Google Scholar 

  • Martignoni, G., & Eble, J. N. (2003). Carcinoid tumors of the urinary bladder. Immunohistochemical study of 2 cases and review of the literature. Archives of Pathology & Laboratory Medicine, 127, 22–24.

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  • Mc Cabe, J. E., Das, S., Dowling, P., et al. (2005). Oncocytic carcinoid tumor of the bladder. Journal of Clinical Pathology, 58, 446–447.

    CAS  Google Scholar 

  • Tassar, C. (2011). Carcinoid tumor in the urinary bladder: Unreported features. The American Journal of Surgical Pathology, 35, 1754–1757.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  3. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  4. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Maria Rosaria Raspollini
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  2. Alessia Cimadamore
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  3. Rodolfo Montironi
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  4. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Raspollini, M.R., Cimadamore, A., Montironi, R., Lopez-Beltran, A. (2020). Urinary Tract Well-Differentiated Neuroendocrine Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4978-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4978-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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