Definition
Lipid-rich type of urothelial carcinoma exhibits a transition between conventional urothelial carcinoma and a cell type resembling signet-ring lipoblasts, i.e., large, optically clear, multivacuolated cells.
Clinical Features
Incidence
Lipid-rich type of urothelial carcinoma is a rare variant, with less than 40 cases reported in the literature (Lopez-Beltran et al. 2019).
Age
It has been described in patients from 56 to 80 years old (Leroy et al. 2007).
Sex
It involves more frequently male subjects.
Site
It has been reported in the bladder and in the renal pelvis.
Treatment
Tumor presents with a macroscopic hematuria. Surgical treatment is required.
Outcome
Despite appropriate surgical treatment, the tumor shows aggressive biology, and majority of the patients died because of the disease.
Macroscopy
Grossly, the tumor shows nonspecific features, and the reported cases are large masses of the bladder (Patel...
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References and Further Reading
Leroy, X., Gonzalez, S., Zini, L., & Aubert, S. (2007). Lipoid-cell variant of urothelial carcinoma: A clinicopathologic and immunohisto- chemical study of five cases. The American Journal of Surgical Pathology, 31, 770–773.
Lopez-Beltran, A., Amin, M. B., Oliveira, P. S., et al. (2010). Urothelial carcinoma of the bladder, lipid cell variant: Clinicopathologic findings and LOH analysis. The American Journal of Surgical Pathology, 34, 371–376.
Lopez-Beltran, A., Henriques, V., Montironi, R., et al. (2019). Variants and new entities of bladder cancer. Histopathology, 74, 77–96.
Patel, A., Velilla, R. E., & Shurbaji, M. S. (2018). Lipid-rich variant of urothelial carcinoma presenting as the dominant morphology in a recurrent tumor after local therapy. American Journal of Case Reports, 19, 478–481.
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Canas-Marques, R., Raspollini, M.R., Lopez-Beltran, A. (2019). Urothelial Carcinoma: Lipid-Rich Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4984-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4984-1
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