Definition
Carcinoma of the urinary bladder that histologically resembles lymphoepithelioma of the nasopharynx.
Clinical Features
Incidence
It constitutes about 0.4–1.3% of all bladder carcinomas. Less than 100 cases have been reported. Most patients present with hematuria. Commonly, it presents as advanced stage disease (T2–T3).
Age
It tends to occur in late adulthood (range, 52–81 years; mean, 69 years).
Sex
It is more common in men than in women (3:1 ratio).
Site
Most frequently it is located in the urinary bladder and tumor is solitary. Occasional cases have been reported in the prostate, the renal pelvis, and the upper ureter (Lopez-Beltran et al. 2017).
Treatment
The clinical behavior and the response to chemotherapy are closely correlated with the proportion of the lymphoepithelioma-like component. The pure form is more sensitive to chemotherapy
Outcome
The pure and predominant lymphoepithelioma-like carcinoma of the...
References and Further Reading
Gulley, M. L., Amin, M. B., Nicholls, J. M., et al. (1995). Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. Human Pathology, 26, 1207–1214.
Lopez-Beltran, A., Paner, G., Blanca, A., et al. (2017). Lymphoepithelioma-like carcinoma of the upper urinary tract. Virchows Archiv, 470, 703–709.
Tamas, E. F., Nielsen, M. E., Schoenberg, M. P., et al. (2007). Lymphoepithelioma-like carcinoma of the urinary tract: A clinicopathological study of 30 pure and mixed cases. Modern Pathology, 20, 828–834.
Williamson, S. R., Zhang, S., Lopez-Beltran, A., et al. (2011). Lymphoepithelioma-like carcinoma of the urinary bladder: Clinicopathologic, immunohistochemical, and molecular features. The American Journal of Surgical Pathology, 35, 474–483.
Yang, A. W., Pooli, A., Lele, S. M., et al. (2017). Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: A case report and systematic review for optimal treatment modality for disease-free survival. BMC Urology, 17, 34.
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Canas-Marques, R., Raspollini, M.R., Lopez-Beltran, A. (2019). Urothelial Carcinoma, Lymphoepithelioma-Like Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4985-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4985-1
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