Definition
Invasive urothelial carcinoma characterized by microcysts, macrocysts, or large-to-medium size tubular structures.
Clinical Features
Incidence
It is a very uncommon variant.
Age
The age of presentation of the reported cases varies from 45 to 85 years.
Sex
Microcystic urothelial carcinoma is more common in men than in female patients, with a male-to-female ratio of 2:1.
Site
It is reported in the bladder and in the renal pelvis (Leroy et al. 2002; Perez-Montiel et al. 2006; Pacchioni et al. 2008).
Treatment
The treatment option is the same of the urothelial carcinoma, usual type.
Outcome
There is no apparent striking biologic significance associated with this variant of urothelial carcinoma, with the exception that it represents a potentially pitfall, particularly in limited samples, with benign lesions. The prognosis of this variant...
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References and Further Reading
Leroy, X., Leteurtre, E., De La Taille, A., et al. (2002). Microcystic transitional cell carcinoma. A report of 2 cases arising in the renal pelvis. Archives of Pathology & Laboratory Medicine, 126, 859–861.
Lopez-Beltran, A., Montironi, R., & Cheng, L. (2014). Microcystic urothelial carcinoma: Morphology, immunohistochemistry and clinical behaviour. Histopathology, 64, 872–879.
Pacchioni, D., Bosco, M., Allia, E., et al. (2008). Microcystic urothelial cell carcinoma with neuroendocrine differentiation arising in renal pelvis. Report of a case. Virchows Archiv, 454, 223–227.
Perez-Montiel, D., Wakely, P. E., Hes, O., et al. (2006). High-grade urothelial carcinoma of the renal pelvis: Clinicopathologic study of 108 cases with emphasis on unusual morphologic variants. Modern Pathology, 19, 494–503.
Young, R. H., & Zukerberg, L. R. (1991). Microcystic transitional cell carcinomas of the urinary bladder: A report of four cases. American Journal of Clinical Pathology, 96, 635–639.
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Canas-Marques, R., Raspollini, M.R., Lopez-Beltran, A. (2020). Urothelial Carcinoma, Microcystic Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4986-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4986-1
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