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Urothelial Carcinoma, Plasmacytoid Type

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Diffuse urothelial carcinoma; Plasmacytoid carcinoma; Plasmacytoma-like carcinoma; Signet-ring carcinoma

Definition

Rare variant of urothelial carcinoma composed of cells having a morphological resemblance with plasma cells or monocytes.

Clinical Features

  • Incidence

    It is a very rare variant, accounting only 3% of all invasive urothelial carcinomas.

  • Age

    The age of presentation of the disease varies from 48 to 89 years, with a mean of 68.

  • Sex

    Plasmacytoid urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2/3:1.

  • Site and presentation

    Almost all cases arise in the urinary bladder. There are only two reported cases involving the ureter (Jibril and Stevens 2018) and less than ten reported cases involving the renal pelvis.

    The most common presenting symptom is hematuria; other possible manifestations are lower abdominal pain, urgency, and frequency (Wang et al. 2012).

  • Treatment

    Due to the rarity of this entity, there is a lack of clear...

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References and Further Reading

  • Jibril, A., & Stevens, A. C. (2018). Plasmacytoid urothelial carcinoma of ureter with retroperitoneal metastasis: A case report. The American Journal of Case Reports, 19, 158–162.

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  • Keck, B., Stoehr, R., et al. (2011). The plasmacytoid carcinoma of the bladder—Rare variant of aggressive urothelial carcinoma. International Journal of Cancer, 129(2), 346–354.

    Article  CAS  Google Scholar 

  • Lopez-Beltran, A., Requena, M. J., et al. (2009). Plasmacytoid urothelial carcinoma of the bladder. Human Pathology, 40(7), 1023–1028.

    Article  Google Scholar 

  • Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. (2016). WHO classification of tumors of the urinary system and male genital organs. Lyon: International Agency for Research on Cancer.

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  • Raspollini, M. R., Sardi, I., et al. (2011). Plasmacytoid urothelial carcinoma of the urinary bladder: Clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of a case series. Human Pathology, 42(8), 1149–1158.

    Article  CAS  Google Scholar 

  • Wang, Z., Lu, T., et al. (2012). Plasmacytoid urothelial carcinoma of the urinary bladder: A clinical pathological study and literature review. International Journal of Clinical and Experimental Pathology, 5(6), 601–608.

    PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Caterina Fattorini & Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Caterina Fattorini
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  2. Antonio Lopez-Beltran
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  3. Maria Rosaria Raspollini
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Urothelial Carcinoma, Plasmacytoid Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4989-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4989-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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