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Urothelial Carcinoma, Poorly Differentiated

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 28 Accesses

Synonyms

Large cell undifferentiated carcinoma; Poorly differentiated urothelial carcinoma; Undifferentiated carcinoma

Definition

Urothelial carcinoma, poorly differentiated includes tumors with different morphologies characterized by high malignant mononuclear epithelial cells and multinucleated giant cells (Moch et al. 2016).

Clinical Features

  • Incidence

    These tumors are uncommon.

  • Age

    The age of incidence is the same as invasive urothelial carcinoma.

  • Sex

    There is a male predominance in the few reported cases.

  • Site

    More common in the urinary bladder.

  • Treatment

    Surgery and chemotherapy treatment according to the stage disease.

  • Outcome

    Limited reported data support a poor outcome to this category of poorly differentiated urothelial tumors.

Macroscopy

No specific gross features are associated with these tumors. Most poorly differentiated urothelial carcinomas are reported as large masses.

Microscopy

Histologically, this new category in the current WHO classification of the urinary tract...

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References

  • Baydar, D., Amin, M. B., & Epstein, J. I. (2006). Osteoclast-rich undifferentiated carcinomas of the urinary tract. Modern Pathology, 19, 161–171.

    Article  Google Scholar 

  • Lopez-Beltran, A., Cheng, L., Comperat, E., et al. (2010). Large cell undifferentiated carcinoma of the urinary bladder. Pathology, 42, 364–368.

    Article  CAS  Google Scholar 

  • Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. (2016). WHO classification of tumours of the urinary system and male genital organs. Lyon: International Agency for Research on Cancer.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Maria Rosaria Raspollini
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  2. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Raspollini, M.R., Lopez-Beltran, A. (2020). Urothelial Carcinoma, Poorly Differentiated. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4990-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4990-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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