Definition
UPUMP is composed of a thickened undulating urothelium that lacks cytological atypia and well-developed fibrovascular cores. It is a new designation introduced in the 2016 WHO classification of tumors of the urinary tract that encompasses the former nomenclatures of papillary or flat urothelial hyperplasia (Humphrey et al. 2016). Recent data suggest it may be an early low-grade papillary neoplasm.
Clinical Features
Incidence
It is found in routine follow-up in patients with either a prior or concurrent low-grade papillary urothelial neoplasia and less commonly in the setting of microhematuria or urinary obstructive symptoms.
Age
Mean age 67 years
Sex
Patients are mainly males.
Site
Not known preferred location within the urinary bladder
Treatment
The histological diagnosis of this lesion is done when the resection is advised.
Outcome
These entities may be seen de...
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References and Further Reading
Hartmann, A., Moser, K., Kriegmair, M., et al. (1999). Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma. The American Journal of Pathology, 154, 721–727.
Humphrey, P. A., Moch, H., Cubilla, A. L., et al. (2016). The 2016 WHO classification of tumours of the urinary system and male genital organs-part B: Prostate and bladder tumours. European Urology, 70, 106–119.
Obermann, E., Junker, K., Stoehr, R., et al. (2003). Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses. The Journal of Pathology, 199, 50–57.
Readal, N., & Epstein, J. I. (2010). Papillary urothelial hyperplasia: Relationship to urothelial neoplasms. Pathology, 42, 360–363.
Taylor, D. C., Bhagavan, B. S., Larsen, M. P., et al. (1996). Papillary urothelial hyperplasia. A precursor to papillary neoplasms. The American Journal of Surgical Pathology, 20, 1481–1488.
van Oers, J. M. M., Adam, C., Denzinger, S., et al. (2006). Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder. International Journal of Cancer, 119, 1212–1215.
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Canas-Marques, R., Raspollini, M.R., Lopez-Beltran, A. (2019). Urothelial Proliferation of Uncertain Malignant Potential. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4994-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4994-1
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