Definition
Benign proliferation of small ducts and gland-like structures in the walls of the vas deferens or epididymis (Easley and MecLennan 2006).
Clinical Features
Incidence
It is frequent from 1 to 15 years after vasectomy. It may occur after trauma, unrelated surgery or obstruction (Algaba et al. 2007).
Age
Third, fourth, and fifth decades.
Sex
Male.
Site
Spermatic cord or epididymis; unilateral but rarely bilateral.
Treatment
Resection during vasovasostomy.
Outcome
Excellent
Macroscopy
Firm gray-white nodule less than 1 cm.
Microscopy
Proliferation of small ducts and glands-like structures in the wall of the vas deferens, but also, may be seen in the epididymis (epididymitis nodosa). Ducts and gland-like structures may have perineural location, a fact that should not be mistaken with malignancy. Atypia and mitoses are absent. Sperm may be present in the lumen of the glands....
References and Further Reading
Algaba, F., Mikuz, G., Boccon-Gibod, L., et al. (2007). Pseudoneoplastic lesions of the testis and paratesticular structures. Virchows Archiv, 451, 987–997.
Balogh, K., & Travis, W. D. (1984). The frequency of perineural ductules in vasitis nodosa. American Journal of Clinical Pathology, 82, 710–713.
Easley, S., & MecLennan, G. T. (2006). Vasitis and epididymis nodosa. The Journal of Urology, 175, 467–482.
Goldmann, R. L., & Azzopardi, J. G. (1982). Benign neural invasion in vasitis nodosa. Histopathology, 6, 309–315.
Kezlarian, B. E., Cheng, L., Gupta, N. S., & Williamson, S. R. (2018). Vasitis nodosa and related lesions: A modern immunohistochemical staining profile with special emphasis on novel diagnostic dilemmas. Human Pathology, 73, 164–170.
Kovi, J., & Agbata, A. (1974). Benign neural invasion in vasitis nodosa. Journal of the American Medical Association, 228, 1519.
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Raspollini, M.R., Lopez-Beltran, A. (2019). Vasitis Nodosa. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4995-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4995-1
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