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Yolk Sac Tumor, Postpubertal-Type

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 46 Accesses

Synonyms

Endodermal sinus tumor; Orchioblastoma (British classification, not recommended)

Definition

Yolk sac tumor postpubertal type (YST) is a tumor composed of structures resembling the embryonal yolk sac, allantois, and embryonal mesenchyme.

Clinical Features

  • Incidence

    Pure testicular YST accounted for only 0.6% of GCTs (von Hochstetter and Hedinger 1982), but YST almost always occurs as a component of mixed GCTs in 44% of nonseminomatous tumors.

  • Age

    Mean age of presentation is among 15 and 40 years in male. Rare cases may be seen in the elderly.

  • Site

    The gonadal localization is the usual localization of YST, while primary mediastinal Yolk sac neoplasm is extremely rare.

  • Treatment

    Orchiectomy is the treatment of the primary tumor. For late relapses with glandular and sarcomatoid YSTs resembling somatic-type malignancies, cure of these patients crucially depends on the possibility of radical surgery combined with chemotherapy.

  • Outcome

    The histological variants of YST found in...

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References and Further Reading

  • Howitt, B. E., Magers, M. J., Rice, K. R., Cole, C. D., & Ulbright, T. M. (2015). Many postchemotherapy sarcomatous tumors in patients with testicular germ cell tumors are sarcomatoid yolk sac tumors: A study of 33 cases. The American Journal of Surgical Pathology, 39(2), 251–259.

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  • Kao, C. S., Idrees, M. T., Young, R. H., & Ulbright, T. M. (2012). Solid pattern yolk sac tumor: A morphologic and immunohistochemical study of 52 cases. The American Journal of Surgical Pathology, 36(3), 360–367.

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  • Osman, H., Cheng, L., Ulbright, T. M., & Idrees, M. T. (2016). The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: An immunohistochemical study of 109 cases. Human Pathology, 48, 18–24.

    Article  CAS  Google Scholar 

  • Ulbright, T. M., Roth, L. M., & Brodhecker, C. A. (1986). Yolk sac differentiation in germ cell tumors. A morphologic study of 50 cases with emphasis on hepatic, enteric, and parietal yolk sac features. The American Journal of Surgical Pathology, 10(3), 151–164.

    Article  CAS  Google Scholar 

  • von Hochstetter, A. R., & Hedinger, C. E. (1982). The differential diagnosis of testicular germ cell tumors in theory and practice. A critical analysis of two major systems of classification and review of 389 cases. Virchows Archiv. A, Pathological Anatomy and Histology, 396(3), 247–277.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Colecchia, M., Bertolotti, A. (2019). Yolk Sac Tumor, Postpubertal-Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4997-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4997-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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