Skip to main content
SpringerLink
Log in

Yolk Sac Tumor, Prepubertal-Type

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 36 Accesses

Synonyms

Endodermal sinus tumour; Orchidoblastoma; Type I germ cell tumour of the testis; Yolk sac carcinoma

Definition

It is a germ cell tumour that differentiates to resemble extraembryonic structures including the YST, allantois, and extraembryonic mesenchyme. It is not associated with GCNIS.

Clinical Features

  • Incidence

    The pure form of yolk sac tumor (YST) is the most frequent (80%) GCT of childhood with and estimated incidence of 2–3 cases per year per 1 million children through age 6 years. The average patient age is about 18 months, since most tumors arise in the first 2 years of life. The epidemiologic data about possible racial preferences are contradictory. In some reports, the incidence is equal in black and white children, whereas in other reports, it is just as with adults, namely, white children and Indian prevail.

  • Age

    YST prepubertal type develops at a median age of 16–20 months with very rare cases beyond 6 years.

  • Site

    This tumor occurs in the testis.

  • ...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Grady, R. W., Ross, J. H., & Kay, R. (1995). Patterns of metastatic spread in prepubertal yolk sac tumor of the testis. Journal of Urology, 153(4), 1259–1261.

    Article  CAS  Google Scholar 

  • Kaplan, G. W., Cromie, W. C., Kelalis, P. P., Silber, I., & Tank, E. S., Jr. (1988). Prepubertal yolk sac testicular tumors-report of the testicular tumor registry. Journal of Urology, 140(5 Pt 2), 1109–1112.

    Article  CAS  Google Scholar 

  • Oosterhuis, J. W., Stoop, J. A., Rijlaarsdam, M. A., Biermann, K., Smit, V. T., Hersmus, R., & Looijenga, L. H. (2015). Pediatric germ cell tumors presenting beyond childhood? Andrology, 3(1), 70–77.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alessia Bertolotti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Colecchia, M., Bertolotti, A. (2019). Yolk Sac Tumor, Prepubertal-Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4998-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4998-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation