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Acidophil Stem Cell Tumor, Pituitary

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 71 Accesses

Synonyms

Acidophil stem cell adenoma

Definition

A neoplasm arising in adenohypophysial tissue that is composed of oncocytic epithelial neuroendocrine cells of PIT1-lineage that express PIT1, estrogen receptor alpha (ER), and prolactin, as well as small amount of growth hormone (Asa and Perry 2020;Horvath et al. 1977, 1981).

Clinical Features

  • Incidence

    These rare tumors represent approximately 2% of surgically resected pituitary neuroendocrine tumors (Mete et al. 2018).

  • Age

    These tumors are too rare to have identified any specific age of onset; they have been reported in the pediatric population (Huang et al. 2006).

  • Sex

    These tumors are too rare to have identified any specific gender predilection.

  • Site

    Acidophil stem cell tumors usually arise in the sella turcica. They are usually macrotumors (>1 cm) at the time of diagnosis and often have invasion downwards into the sphenoid sinus as well as invasion upwards and laterally into the cavernous sinuses. They may arise in the sphenoid sinus...

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References and Further Reading

  • Asa, S. L., & Perry, A. (2020). Tumors of the pituitary gland (AFIP atlas of tumor pathology, Series 5). Silver Spring: ARP Press.

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  • Horvath, E., Kovacs, K., Singer, W., Ezrin, C., & Kerenyi, N. A. (1977). Acidophil stem cell adenoma of the human pituitary. Archives of Pathology & Laboratory Medicine, 101, 594–599.

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  • Horvath, E., Kovacs, K., Singer, W., Smyth, H. S., Killinger, D. W., Ezrin, C., et al. (1981). Acidophil stem cell adenoma of the human pituitary: Clinicopathologic analysis of 15 cases. Cancer, 47, 761–771.

    Article  CAS  Google Scholar 

  • Huang, C., Ezzat, S., Asa, S. L., & Hamilton, J. (2006). Dopaminergic resistant prolactinomas in the peripubertal population. Journal of Pediatric Endocrinology & Metabolism, 19, 951–953.

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  • Mete, O., Cintosun, A., Pressman, I., & Asa, S. L. (2018). Epidemiology and biomarker profile of pituitary adenohypophysial tumors. Modern Pathology, 31, 900–909.

    Article  CAS  Google Scholar 

  • Papathomas, T. G., Gaal, J., Corssmit, E. P., Oudijk, L., Korpershoek, E., Heimdal, K., et al. (2014). Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: Aclinicopathological and molecular analysis. European Journal of Endocrinology, 170, 1–12.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA

    Sylvia L. Asa

Authors
  1. Sylvia L. Asa
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Corresponding author

Correspondence to Sylvia L. Asa .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Asa, S.L. (2020). Acidophil Stem Cell Tumor, Pituitary. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5032-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5032-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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