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C-Cell Hyperplasia

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 32 Accesses

Synonyms

Calcitonin cell hyperplasia; Thyroid clear cell hyperplasia

Definition

A multifocal proliferation of thyroid C cells that results in more than 7 cells per cluster, follicles completely surrounded by C cells, and/or C cells extending beyond their normal at the junction of the upper third and lower two thirds of the lateral thyroid lobes, i.e., in the lower lobes (DeLellis et al. 2004; Wolfe et al. 1974). C cell hyperplasia may be primary or secondary; the former is usually nodular and premalignant (Mete and Asa 2013), whereas the latter is a diffuse nonnodular proliferation that is a reactive phenomenon and usually has no preneoplastic connotation but may also be seen in patients with chronic hypercalcemia or thyroiditis. C cell hyperplasia is also caused by some drugs, mainly antidiabetic incretins (glucagon-like peptide-1 analogs such as exenatide, liraglutide, and taspoglutide).

Clinical Features

  • Incidence

    Primary C cell hyperplasia is a precursor lesion in patients with...

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References and Further Reading

  • DeLellis, R. A., Lloyd, R. V., Heitz, P. U., & Eng, C. (2004). Pathology and genetics of Tumours of endocrine organs. Lyons: IARC Press.

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  • Mete, O., & Asa, S. L. (2013). Precursor lesions of endocrine system neoplasms. Pathol, 45, 316–330.

    Article  CAS  Google Scholar 

  • Wells, S. A., Jr., Asa, S. L., Dralle, H., Elisei, R., Evans, D. B., Gagel, R. F., et al. (2015). Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid, 25, 567–610.

    Article  Google Scholar 

  • Wolfe, H. J., DeLellis, R. A., & Tashjian, A. H., Jr. (1974). Distribution of calcitonin-containing cells in the normal adult human thyroid gland: A correlation of morphology with peptide content. The Journal of Clinical Endocrinology and Metabolism, 38, 688–694.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, University Hospitals, Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA

    Sylvia L. Asa

Authors
  1. Sylvia L. Asa
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Corresponding author

Correspondence to Sylvia L. Asa .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Asa, S.L. (2020). C-Cell Hyperplasia. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5033-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5033-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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