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Antidiuretic Hormone (ADH)

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 38 Accesses

Synonyms

Argipressin; Vasopressin (AVP)

Definition

ADH is an antidiuretic hormone released by the hypothalamus and stored in the posterior pituitary gland.

Features

ADH is a nonapeptide released as prohormone (prepropressophysin) by the hypothalamus in storage vesicles. In the Golgi apparatus, the signal peptide portion is cleaved from prepropressophysin to produce a prohormone that is stored in secretory vesicles transported through the hypothalamic-hypophysial tract where they are ultimately released in the posterior pituitary. In detail, prepropressophysin contains a signal peptide, neurophysin II, and a glycoprotein. The signal peptide is removed in the Golgi apparatus to produce a prohormone stored in secretory vesicles. During the translocation to the posterior pituitary gland, the prohormone is cleaved to produce ADH (Cuzzo and Lappin 2019).

ADH plays an important role in body’s osmotic balance, blood pressure, and kidney function regulation. Once released, ADH binds its type-2...

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References and Further Reading

  • Arima, H., Azuma, Y., Morishita, Y., & Hagiwara, D. (2016). Central diabetes insipidus. Nagoya Journal of Medical Science, 78, 349–358.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bockenhauer, D., & Bichet, D. G. (2015). Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus. Nature Reviews. Nephrology, 11(10), 576–588.

    Article  CAS  Google Scholar 

  • Boone, M., & Deen, P. M. T. (2008). Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. European Journal of Physiology, 456, 1005–1024.

    Article  CAS  Google Scholar 

  • Cuzzo, B., & Lappin, S. L. (2019). Vasopressin (antidiuretic hormone, ADH). Treasure Island: StatPearls Publishing.

    Google Scholar 

  • Sterns, R. H. (2015). Disorders of plasma sodium – Causes, consequences, and correction. New England Journal of Medicine, 372, 55–65.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Dipartimento di Medicina Clinica e Chirurgia, University “Federico II” of Naples, Naples, Italy

    Annamaria Colao, Claudia Pivonello & Mariarosaria Negri

Authors
  1. Annamaria Colao
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  2. Claudia Pivonello
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  3. Mariarosaria Negri
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Corresponding author

Correspondence to Annamaria Colao .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Colao, A., Pivonello, C., Negri, M. (2020). Antidiuretic Hormone (ADH). In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5100-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5100-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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