Skip to main content
SpringerLink
Log in

Calcitonin Gene-Related Peptide (CGRP)

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 16 Accesses

Synonyms

Calcitonin gene-related peptide (CGRP); CGRP I and II; α and βCGRP

Definition

Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. There are two major isoforms of CGRP, αCGRP, and βCGRP that are encoded by two distinct genes. Alternative splicing of the CALC1 gene, which also encodes calcitonin, results in the transcript for αCGRP. The resulting 121-amino acid pro-hormone is then generated through cleavage of the protein. βCGRP is encoded by the CALC2 gene. At the protein level, the two forms have a homology of >90%. The receptor for CGRP is a G protein-coupled receptor (GPRC class B), the calcitonin receptor-like receptor (CALCRL), that must form a heterodimer with the receptor activity-modifying protein 1 (RAMP1) to be functional. CGRP is widely expressed in nociceptive pathways in the central and peripheral nervous system, and its receptor is also expressed in pain pathways.

Features

The trigeminovascular system consists of sensory neurons that originate...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Edvinsson, L., Haanes, K. A., Warfvinge, K., & Krause, D. N. (2018). CGRP as the target of new migraine therapies – Successful translation from bench to clinic. Nature Reviews. Neurology, 14(6), 338–350.

    Article  CAS  Google Scholar 

  • Russell, F. A., King, R., Smillie, S. J., Kodji, X., & Brain, S. D. (2014). Calcitonin gene-related peptide: Physiology and pathophysiology. Physiological Reviews, 94(4), 1099–1142.

    Article  CAS  Google Scholar 

  • Schou, W. S., Ashina, S., Amin, F. M., Goadsby, P. J., & Ashina, M. (2017). Calcitonin gene-related peptide and pain: A systematic review. The Journal of Headache and Pain, 18(1), 34.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Endocrinology, Diabetes and Metabolism, University Hospital, University of Lausanne, Lausanne, Switzerland

    Peter Kopp

Authors
  1. Peter Kopp
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Kopp .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Kopp, P. (2022). Calcitonin Gene-Related Peptide (CGRP). In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5165-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5165-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation