Synonyms
Definition
The vasoactive intestinal peptide (VIP) is a 28-amino acid peptide belonging to the secretin/glucagon hormone superfamily. It was first isolated from porcine duodenum in 1970 and its name derives from its vasodilatory effect (Said and Mutt 1970).
Features
VIP derives from the cleavage of a 170-amino acid precursor molecule (prepro-VIP) encoded by a gene containing seven exons, which is located in the chromosomal region 6q24. The prepro-VIP also contains the sequence of the peptide histidine methionine (PHM) that shares similar physiological effects with VIP, although it is less potent.
VIP is widely distributed in several different organs and tissues including the central and peripheral nervous system and the digestive, respiratory, reproductive, and cardiovascular systems, where it acts as a neurotransmitter and/or neuroendocrine releasing factor. VIP plays a regulatory role in different physiological processes related to...
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References
Casado-Bedmar, M., Heil, S. D. S., Myrelid, P., Söderholm, J. D., & Keita, Å. V. (2019). Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis. Neurogastroenterology and Motility, 31, e13503.
Delgado, M., Gonzalez-Rey, E., & Ganea, D. (2004). VIP/PACAP preferentially attract Th2 effectors through differential regulation of chemokine production by dendritic cells. The FASEB Journal, 18, 1453–1455.
Fung, C., Unterweger, P., Parry, L. J., Bornstein, J. C., & Foong, J. P. (2014). VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum. American Journal of Physiology. Gastrointestinal and Liver Physiology, 306, G748–G758.
Gülçür, E., Thaqi, M., Khaja, F., Kuzmis, A., & Önyüksel, H. (2013). Curcumin in VIP-targeted sterically stabilized phospholipid nanomicelles: A novel therapeutic approach for breast cancer and breast cancer stem cells. Drug Delivery and Translational Research, 3, 562–574.
Iwasaki, M., Akiba, Y., & Kaunitz, J. D. (2019). Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. F1000Res, 8, F1000 Faculty Rev-1629.
Moody, T. W., Nuche-Berenguer, B., & Jensen, R. T. (2016). Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer. Current Opinion in Endocrinology, Diabetes, and Obesity, 23, 38–47.
Reubi, J. C., Läderach, U., Waser, B., Gebbers, J. O., Robberecht, P., & Laissue, J. A. (2000). Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin. Cancer Research, 60, 3105–3112.
Said, S. I., & Mutt, V. (1970). Polypeptide with broad biological activity: Isolation from small intestine. Science, 169, 1217–1218.
Tang, B., Yong, X., Xie, R., Li, Q. W., & Yang, S. M. (2014). Vasoactive intestinal peptide receptor-based imaging and treatment of tumors (Review). International Journal of Oncology, 44, 1023–1031.
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La Rosa, S. (2022). Vasoactive Intestinal Peptide (VIP). In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5202-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5202-1
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