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111In-Pentetreotide Scintigraphy

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

OctreoScan, 111Indium-DTPA-[D-Phe1]-Octreotide scintigraphy; Somatostatin receptor scintigraphy (SRS)

Definition

Scintigraphic procedure to visualize Somatostatin Receptor (SSTR) 2 positive tumors. Usually used in the setting of well-differentiated neuroendocrine neoplasms (GEP–NET).

Principle

Indium-111 is a gamma rays emitting isotope with a relatively long half-live of 2.8 days. Pentetreotide (DTPA-Octreotide) is a somatostatin analog mainly binding to SSTR2 carrying the radioactive Indium-111. The radioactive isotope the decays by emitting gamma rays which are collimated to a specific geometry and then detected by a gamma camera. The imaging protocol usually consists of planar imaging and tomographic single photon emission tomography (SPECT) imaging.

Methodology

Scintigraphic planar and tomographic SPECT are usually acquired after 4 h, 24 h, and 48 h. Special caution has to be given to pregnancy, breast feeding, and children. In these cases, nonradiant alternatives need to...

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References and Further Reading

  • Bombardieri, E., Ambrosini, V., Aktolun, C., Baum, R. P., Bishof-Delaloye, A., Del Vecchio, S., Maffioli, L., Mortelmans, L., Oyen, W., Pepe, G., & Chiti, A. (2010). 111In-pentetreotide scintigraphy: Procedure guidelines for tumour imaging. European Journal of Nuclear Medicine and Molecular Imaging, 37(7), 1441–1448.

    Article  Google Scholar 

  • Maxwell, J. E., & Howe, J. R. (2015). Imaging in neuroendocrine tumors: An update for the clinician. International Journal of Endocrine Oncology, 2(2), 159–168.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Division of Nuclear Medicine, University Hospital of Lausanne, Lausanne, Switzerland

    Niklaus Schaefer

Authors
  1. Niklaus Schaefer
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Correspondence to Niklaus Schaefer .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Schaefer, N. (2021). 111In-Pentetreotide Scintigraphy. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5266-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5266-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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