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131I-MIBG Scintigraphy

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Iobenguane scintigraphy; Metaiodobenzylguanidine scintigraphy

Definition

Scintigraphic procedure visualizing the activity or distribution of the norepinephrine transmitter. Iobenguane (MIBG) is an aralkylguanidine analogue.

Principle

Iodine-131 bound to MIBG is transported via the epinephrine transporter and then sored into the neurosecretory granule. It is therefore primarily used to visualize tumors of the sympathoadrenal system. Iodine-131, the radioactive isotope, decays by emitting high-energy gamma rays which are collimated to a specific geometry and then detected by a gamma camera. The imaging protocol usually consists of planar imaging and tomographic single photon emission tomography (SPECT) imaging.

Methodology

Scintigraphic planar and tomographic SPECT (single photon emission tomography) are usually acquired after 24 h and 48 h. Special caution has to be given to pregnancy, breast-feeding, and children. In these cases, non-radiant alternatives needs to be discussed....

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References and Further Reading

  • Bombardieri, E., Giammarile, F., Aktolun, C., Baum, R. P., Bischof Delaloye, A., Maffioli, L., Moncayo, R., Mortelmans, L., Pepe, G., Reske, S. N., Castellani, M. R., & Chiti, A. (2010). 131I/123I-Metaiodobenzylguanidine (mIBG) scintigraphy: Procedure guidelines for tumour imaging. European Journal of Nuclear Medicine and Molecular Imaging, 37(12), 2436–2446.

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Authors and Affiliations

  1. Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, University Hospital of Lausanne, Lausanne, Switzerland

    Niklaus Schaefer

Authors
  1. Niklaus Schaefer
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Corresponding author

Correspondence to Niklaus Schaefer .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Schaefer, N. (2021). 131I-MIBG Scintigraphy. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5267-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5267-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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