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Tumors of Uncertain Malignant Potential

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Atypical adenoma (adenoma with atypia); Well-differentiated tumor of uncertain behavior

Definition

Tumors of uncertain malignant potential (UMP) are encapsulated or well-circumscribed follicular-patterned thyroid tumors with questionable capsular or vascular invasion, independent of the presence or absence of papillary carcinoma (PTC)-type nuclear alterations. There are two types of UMP tumors (Tallini and Giordano 2018):

  • Follicular Tumor of Uncertain Malignant Potential (FT-UMP): A tumor of well-differentiated follicular cells with no PTC-type nuclear alterations that is encapsulated or well circumscribed in which capsular or vascular invasion is uncertain, i.e., a tumor with pathologic features indeterminate between follicular adenoma and follicular carcinoma.

  • Well-Differentiated Tumor of Uncertain Malignant Potential (WDT-UMP): A tumor of well-differentiated follicular cells with PTC-type nuclear alterationsthat are well- or partially developed and in which capsular or...

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References and Further Reading

  • Baloch, Z. W., & LiVolsi, V. A. (2014). Follicular-patterned afflictions of the thyroid gland: Reappraisal of the most discussed entity in endocrine pathology. Endocrine Pathology, 25(1), 12–20.

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  • Chan, J. (2002). Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma. American Journal of Clinical Pathology, 117(1), 16–18.

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  • Kakudo, K., Bai, Y., Liu, Z., Li, Y., Ito, Y., & Ozaki, T. (2012). Classification of thyroid follicular cell tumors: With special reference to borderline lesions. Endocrine Journal, 59(1), 1–12.

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  • Mete, O., & Asa, S. L. (2011). Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation. Modern pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, 24(12), 1545–1552.

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  • Rosai, J., DeLellis, R. A., Carcangiu, M. L., Frable, W. J., & Tallini, G. (2014). Tumors of the thyroid and parathyroid glands. Silver Spring: American Registry of Pathology.

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  • Tallini, G., & Giordano, T. J. (2018). Thyroid gland. In J. R. Goldblum, L. W. Lamps, J. K. McKenney, & J. L. Myers (Eds.), Rosai and Ackerman’s surgical pathology (pp. 278–343). Philadelphia: Elsevier.

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  • Williams, E. D. (2000). Guest editorial: Two proposals regarding the terminology of thyroid tumors. International Journal of Surgical Pathology, 8(3), 181–183.

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  • Zhu, Y., Li, Y., Jung, C. K., Song, D. E., Hang, J. F., Liu, Z., Jain, D., Lai, C. R., Hirokawa, M., Kakudo, K., & Bychkov, A. (2020). Histopathologic assessment of capsular invasion in follicular thyroid neoplasms-an observer variation study. Endocrine Pathology, 31(2), 132–140.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Anatomic Pathology, University of Bologna School of Medicine, Bologna, Italy

    Giovanni Tallini & Antonio De Leo

Authors
  1. Giovanni Tallini
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  2. Antonio De Leo
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Corresponding author

Correspondence to Giovanni Tallini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Tallini, G., De Leo, A. (2021). Tumors of Uncertain Malignant Potential. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5284-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5284-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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