Skip to main content
SpringerLink
Log in

Angiofibroma, Nasopharyngeal

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Juvenile angiofibroma

Definition

Nasopharyngeal angiofibroma (NA) is a benign but locally aggressive fibrovascular tumor, which predominantly occurs in adolescent males.

Clinical Features

  • Incidence

    NA is a rare tumor with an estimated incidence of 0.05–1% of all head and neck tumors (Boghani et al. 2013).

  • Age

    Patients range in age between 10 and 25 years, with a mean of 17 years (Boghani et al. 2013).

  • Sex

    It shows a clear predilection for adolescent male subjects.

  • Site

    NA originates in the nasopharynx or less frequently in the posterior nasal cavity.

  • Treatment

    The choice of the appropriate treatment is based on tumor extension (Yi et al. 2013). Surgical resection is currently accepted as the treatment of choice, and transnasal endoscopic approach is the main modality employed in early stage disease (Douglas and Wormald 2006). In cases with intracranial extension, endoscopic resection can be considered as approach to treatment (Leong 2013). A multimodality approach, with...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Abraham, S. C., Montgomery, E. A., Giardiello, F. M., & Wu, T. T. (2001). Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. The American Journal of Pathology, 158, 1073–1078.

    Article  CAS  Google Scholar 

  • Boghani, Z., Husain, Q., Kanumuri, V. V., Khan, M. N., Sangvhi, S., Liu, J. K., & Eloy, J. A. (2013). Juvenile nasopharyngeal angiofibroma: A systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. The Laryngoscope, 123, 859–869.

    Article  Google Scholar 

  • Douglas, R., & Wormald, P. J. (2006). Endoscopic surgery for juvenile nasopharyngeal angiofibroma: Where are the limits? Current Opinion in Otolaryngology & Head and Neck Surgery, 14, 1–5.

    Article  Google Scholar 

  • Ferouz, A. S., Mohr, R. M., & Paul, P. (1995). Juvenile nasopharyngeal angiofibroma and familial adenomatous polyposis: An association? Otolaryngology and Head and Neck Surgery, 113, 435–439.

    Article  CAS  Google Scholar 

  • Gates, G. A., Rice, D. H., Koopmann, C. F., Jr., & Schuller, D. E. (1992). Flutamide-induced regression of angiofibroma. The Laryngoscope, 102, 641–644.

    Article  CAS  Google Scholar 

  • Hwang, H. C., Mills, S. E., Patterson, K., et al. (1998). Expression of androgen receptors in nasopharyngeal angiofibroma: An immunohistochemical study of 24 cases. Modern Pathology, 11, 1122–1126.

    CAS  PubMed  Google Scholar 

  • Klockars, T., Renkonen, S., Leivo, I., Hagström, J., & Mäkitie, A. A. (2010). Juvenile nasopharyngeal angiofibroma: No evidence for inheritance or association with familial adenomatous polyposis. Familial Cancer, 9, 401–403.

    Article  Google Scholar 

  • Leong, S. C. (2013). A systematic review of surgical outcomes for advanced juvenile nasopharyngeal angiofibroma with intracranial involvement. The Laryngoscope, 123, 1125–1131.

    Article  Google Scholar 

  • Makek, M. S., Andrews, J. C., & Fisch, U. (1989). Malignant transformation of a nasopharyngeal angiofibroma. The Laryngoscope, 99, 1088–1092.

    Article  CAS  Google Scholar 

  • Montag, A. G., Tretiakova, M., & Richardson, M. (2006). Steroid hormone receptor expression in nasopharyngeal angiofibromas. Consistent expression of estrogen receptor beta. American Journal of Clinical Pathology, 125, 832–837.

    Article  CAS  Google Scholar 

  • Renkonen, S., Heikkilä, P., Haglund, C., Mäkitie, A. A., & Hagström, J. (2013). Tenascin-C, GLUT-1, and syndecan-2 expression in juvenile nasopharyngeal angiofibroma: Correlations to vessel density and tumor stage. Head & Neck, 35, 1036–1042.

    Article  Google Scholar 

  • Wang, J. J., Sun, X. C., Hu, L., Liu, Z. F., Yu, H. P., Li, H., Wang, S. Y., & Wang, D. H. (2013). Endoglin (CD105) expression on microvessel endothelial cells in juvenile nasopharyngeal angiofibroma: Tissue microarray analysis and association with prognostic significance. Head & Neck, 35, 1719–1725.

    Article  Google Scholar 

  • Yi, Z., Fang, Z., Lin, G., Lin, C., Xiao, W., Li, Z., Cheng, J., & Zhou, A. (2013). Nasopharyngeal angiofibroma: A concise classification system and appropriate treatment options. American Journal of Otolaryngology, 34, 133–141.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Alessandro Franchi

Authors
  1. Alessandro Franchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alessandro Franchi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Franchi, A. (2019). Angiofibroma, Nasopharyngeal. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5344-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5344-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation