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Atypical Pleomorphic Lipomatous Tumor

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Atypical spindle cell/pleomorphic lipomatous tumor

Definition

Atypical pleomorphic lipomatous tumor is a low-grade adipocytic neoplasm with a pleomorphic lipoma-like appearance, but with atypical morphologic features (including atypical spindle cells, pleomorphic (multinucleated) cells, pleomorphic lipoblasts, and poor circumscription). This tumor shows important overlapping morphologic and genetic features with the atypical spindle cell lipomatous tumor, suggesting atypical pleomorphic lipomatous tumor and atypical spindle cell lipomatous tumor belong to the same spectrum (“atypical spindle cell/pleomorphic lipomatous tumor”) (Creytens et al. 2017; Mariño-Enriquez et al. 2017).

Clinical Features

  • Incidence

    The real incidence of atypical pleomorphic lipomatous tumor is difficult to assess, as most of our knowledge of this very recently described entity is based on small series or single case reports (Creytens et al. 2017, 2019; Bahadır et al. 2018; Boyd 2019).

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References and Further Reading

  • Bahadır, B., Behzatoğlu, K., Hacıhasanoğlu, E., et al. (2018). Atypical spindle cell/pleomorphic lipomatous tumor: A clinicopathologic, immunohistochemical, and molecular study of 20 cases. Pathol Int, 68(10), 550–556.

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  • Boyd, A. S. (2019). An atypical pleomorphic lipomatous tumor arising on the cheek. J Cutan Pathol. https://doi.org/10.1111/cup.13540. Epub ahead of print.

  • Creytens, D., Mentzel, T., Ferdinande, L., et al. (2017). “Atypical” pleomorphic lipomatous tumor: A clinicopathologic, immunohistochemical and molecular study of 21 cases, emphasizing its relationship to atypical spindle cell lipomatous tumor and suggesting a morphologic spectrum (atypical spindle cell/pleomorphic lipomatous tumor). Am J Surg Pathol, 41(11), 1443–1455.

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  • Creytens, D., Mentzel, T., Ferdinande, L., et al. (2018a). Atypical mitoses are present in otherwise classical pleomorphic lipomas-reply. Hum Pathol, 81, 300–302.

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  • Creytens, D., Mentzel, T., Ferdinande, L., et al. (2018b). Atypical multivacuolated lipoblasts and atypical mitoses are not compatible with the diagnosis of spindle cell/pleomorphic lipoma. Hum Pathol, 74, 188–189.

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  • Creytens, D., Mentzel, T., Ferdinande, L., van Gorp, J., Van Dorpe, J., & Flucke, U. (2019). Fat-rich (spindle cell-poor) variant of atypical spindle cell/pleomorphic lipomatous tumor: striking mimic of classical atypical lipomatous tumor/well-differentiated liposarcoma. Int J Surg Pathol. https://doi.org/10.1177/1066896919846561. Epub ahead of print.

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  • Mariño-Enriquez, A., Nascimento, A. F., Ligon, A. H., et al. (2017). Atypical spindle cell lipomatous tumor: Clinicopathologic characterization of 232 cases demonstrating a morphologic spectrum. Am J Surg Pathol, 41(2), 234–244.

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Author information

Authors and Affiliations

  1. Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium

    David Creytens

Authors
  1. David Creytens
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Corresponding author

Correspondence to David Creytens .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Creytens, D. (2019). Atypical Pleomorphic Lipomatous Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5355-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5355-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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