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Calcifying Aponeurotic Fibroma

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Aponeurotic fibroma; Juvenile aponeurotic fibroma

Definition

Calcifying aponeurotic fibroma (CAF) is a rare tumor, usually occurring on the hands or feet, especially in the first and second decades of life. It is infiltrative in nature, so has a relatively high local recurrence rate.

Clinical Features

  • Incidence

    CAF is a very rare soft-tissue tumor. Fewer than 100 cases of it have been reported in the English literature since 1953. In almost all cases, there was no association with other diseases, with just a single case being complicated with Masson’s tumor (Romano et al. 2017).

  • Age

    CAF usually occurs in children and adolescents but has been reported over a wide range of ages. Indeed, our literature review shows that the ages of reported CAF patients range from 2 months to 71 years (median 10 years).

  • Sex

    A male predominance of this condition has been reported, and the literature review (Table 1) also reveals a slight tendency for this (M:F = 26:22).

    Table 1 Case Series of...

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References

  • Cho, Y. H., Ahn, K. S., Kang, C. H., Kim, C. H. (2015). Calcifying aponeurotic fibroma of the dorsum of the foot: Radiographic and magnetic resonance imaging findings in a four-year-old boy. Iranian Journal of Radiology, 12(2), e23911. https://doi.org/10.5812/iranjradiol.23911. eCollection 2015 Apr.

  • Choi, S. J., Ahn, J. H., Kang, G., Lee, J. H., Park, M. S., Ryu, D. S., & Jung, S. M. (2008). Calcifying aponeurotic fibroma with osseous involvement of the finger: A case report with radiologic and US findings. Korean Journal of Radiology, 9(1), 91–93.

    Article  Google Scholar 

  • DeSimone, R. S., & Zielinski, C. J. (2001). Calcifying aponeurotic fibroma of the hand. A case report. Journal of Bone and Joint Surgery, 83-A(4), 586–588.

    Article  Google Scholar 

  • Fetsch, J. F., & Miettinen, M. (1998). Calcifying aponeurotic fibroma: A clinicopathologic study of 22 cases arising in uncommon sites. Human Pathology, 29, 1504–1510.

    Article  CAS  Google Scholar 

  • Giuffre, J. L., Kovachevich, R., Bishop, A. T., & Shin, A. Y. (2011). Recurrent calcifying aponeurotic fibroma of the thumb: Case report. The Journal of Hand Surgery, 36(1), 110–115.

    Article  Google Scholar 

  • Hasegawa, H. K., Park, S., & Hamazaki, M. (2006). Calcifying aponeurotic fibroma of the knee: A case report with radiological findings. Journal of Dermatology, 33(3), 169–173.

    Article  Google Scholar 

  • Hocar, O., Yacoubi, H., Akhdari, N., Amal, S., Ait Essi, F., Latifi, M., Rais, H., & Belaabidia, B. (2011). Unusual presentation of a rare tumor of the dorsal surface of the foot. International Scholarly Research Notices: Dermatology, 2011, 704549. https://doi.org/10.5402/2011/704549.

    Article  CAS  Google Scholar 

  • Kilpatrick, S. E. (2013). Calcifying aponeurotic fibroma. In C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, & F. Mertens (Eds.), World Health Organization classification of tumours of soft tissue and bone (4th ed., p. 63). Lyon: IARC Press.

    Google Scholar 

  • Kramer, J. M., Doscher, J. C., Ruvinsky, M., & Fantasia, J. E. (2010). Calcifying aponeurotic fibroma with bone islands exhibiting hematopoiesis: A case report and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, 109(6), 878–882.

    Article  Google Scholar 

  • Lee, S. M., Ha, D. H., Kang, H., & Rho, J. Y. (2018). Intraarticular calcifying aponeurotic fibroma of the wrist: Mimicking gout or calcium pyrophosphate dihydrate deposition disease. Skeletal Radiology, 47(5), 729–734.

    Article  Google Scholar 

  • Nishio, J., Inamitsu, H., Iwasaki, H., Hayashi, H., & Naito, M. (2014). Calcifying aponeurotic fibroma of the finger in an elderly patient: CT and MRI findings with pathologic correlation. Experimental and Therapeutic Medicine, 8(3), 841–843.

    Article  Google Scholar 

  • Puls, F., Hofvander, J., Magnusson, L., Nilsson, J., Haywood, E., Sumathi, V. P., Mangham, D. C., Kindblom, L. G., & Mertens, F. (2016). FN1-EGF gene fusions are recurrent in calcifying aponeurotic fibroma. Journal of Pathology, 238(4), 502–507.

    Article  CAS  Google Scholar 

  • Romano, N., Fischetti, A., Musetto, I., Bianchi, R., & Muda, A. (2017). Masson’s tumor and calcifying aponeurotic fibroma: Two rare softtissue lesions in the same finger. High-resolution ultrasound features with histopathological correlations. Medical Ultrasonography, 19(4), 457–461.

    Article  Google Scholar 

  • Sekiguchi, T., Nakagawa, M., Miwa, S., Shiba, A., Ozawa, Y., Shimohira, M., Sakurai, K., & Shibamoto, Y. (2017). Calcifying aponeurotic fibroma in a girl: MRI findings and their chronological changes. Radiology Case Reports, 12(3), 620–623.

    Article  Google Scholar 

  • Sharma, R., Punia, R. S., Sharma, A., & Marwah, N. (1998). Juvenile (calcifying) aponeurotic fibroma of the neck. Pediatric Surgery International, 13(4), 295–296.

    Article  CAS  Google Scholar 

  • Shim, S. W., Kang, B. S., Lee, C. C., Suh, J. H., & Shim, H. S. (2016). MRI features of calcifying aponeurotic fibroma in the upper arm: A case report and review of the literature. Skeletal Radiology, 45(8), 1139–1143.

    Article  Google Scholar 

  • Tai, L. H., Johnston, J. O., Klein, H. Z., Rowland, J., & Sudilovsky, D. (2001). Calcifying aponeurotic fibroma features seen on fine-needle aspiration biopsy: Case report and brief review of the literature. Diagnostic Cytopathology, 24(5), 336–339.

    Article  CAS  Google Scholar 

  • Takaku, M., Hashimoto, I., Nakanishi, H., Kurashiki, T. (2011). Calcifying aponeurotic fibroma of the elbow: Case report. The Journal of Medical Investigation, 58(1–2), 159–162.

    Article  Google Scholar 

  • Thakur, J. S., Diwana, V. K., Sharma, S., & Thakur, A. (2011). Calcifying (juvenile) aponeurotic fibroma of the scalp. Ear, Nose, and Throat Journal, 90(10), E14–E16.

    Article  Google Scholar 

  • Yura, S., Terahata, S., Ohga, N., & Ooi, K. (2008). A case of calcifying aponeurotic fibroma arising in the medial pterygoid muscle. Journal of Oral and Maxillofacial Surgery, 66(2), 359–361.

    Article  Google Scholar 

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Correspondence to Yoshinao Oda .

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Mori, T., Yamada, Y., Oda, Y. (2020). Calcifying Aponeurotic Fibroma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5358-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5358-1

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